ABSTRACT
Objective: To explore the effect of cognitive behavioral intervention therapy on
the cellular immune function of patients undergoing radical mastectomy for the
first time, and to provide a scientific basis for improving the treatment of
breast cancer patients. Methods: 100 patients with breast cancer who
were eligible for admission to the Department of Breast Surgery, Hainan
Provincial People’s Hospital from January 2016 to December 2017 were selected
as subjects. It is the first time to improve the radical mastectomy. They were
randomly divided into control group and intervention group, 50 cases each. The
control group used conventional treatment and routine care. On the
basis of this, the intervention group conducted cognitive behavioral
interventions including cognitive reconstruction and behavioral therapy. The
patients were measured for serum IL-2, IL-4, IL-6, IL-8 and TNF-α levels on the second day after
admission and three months after discharge. The
changes of serum IL-2, IL-4, IL-6, IL-8 and TNF-α levels in the two groups were compared before and after cognitive
intervention. Results: The concentrations of IL-2, IL-4, IL-6, IL-8 and
TNF-α in the serum of the
intervention group and the control group before intervention were compared. The
difference was not statistically significant (P > 0.05). After the
intervention, the serum levels of IL-2, IL-4 and IL-8 in the intervention group
were lower than before the intervention. The
concentration of TNF-α was higher
than before the intervention. The
difference was statistically significant (P < 0.05). Conclusion:
Cognitive behavioral intervention therapy can change the levels of IL-2, IL-4,
IL-6, IL-8 and TNF-α in serum of
breast cancer patients. It has a positive effect on the regulation of immune function in breast
cancer patients.
Share and Cite:
Huang, P. , Guo, J. , Guo, M. , Yang, Y. , Jiang, X. and Cen, W. (2019) Effect of Cognitive Behavioral Intervention Therapy on Immune Index in Patients with Breast Cancer.
Advances in Breast Cancer Research,
8, 77-85. doi:
10.4236/abcr.2019.82006.