Author(s)

Samreen Soomro¹, Tazeen Mustansir², Talat Mirza³

¹Faculty of Pharmacy, Northern Border University, NBU, Rafha, Saudi Arabia.
²Department of Pathology, Dow International Medical College, DIMC, Dow Diagnostic Reference and Research Lab, DDRRL, Dow University of Health Sciences, DUHS, Karachi, Pakistan.
³Research and Postgraduates Studies, Ziauddin University, Karachi, Pakistan.

Objective: To determine the prevalence of H. pylori induced gastritis and its association with development of chronic inflammation and carcinoma with reference to updated Sydney classification, to ensure the proper diagnosis and timely treatment. Methods: This was a cross sectional study conducted at the Department of Pathology, Dow Diagnostic Reference and Research Laboratory for the year 2018. Analysis of about 726 gastric biopsy specimens was performed to identify the epidemiological status of the disease. On the other hand, 100 of the specimens were analysed according to Sydney classification to ensure the accurate diagnosis of the gastritis and related disorders. Out of 726 biopsy samples positive samples for carcinoma were investigated in detail histological features. Giemsa stain was used to visualize the h pylori bacteria and the sections of biopsies were subjected to haematoxylin and eosin staining for histological analysis. Results: Out of 727 cases, H. pylori was found in 492 (67.8%) patients. About 1.79% (13) cases were identified as adenocarcinoma, 0.27% (2) squamous cell carcinoma and 0.13% (1) as B cell non Hodgkin lymphoma. Results of Sydney classification. The degree of chronic inflammatory activity was 57% mild; 38% moderate and 3% severe out of a total of 67% cases in an active phase of Hp gastritis. Hp-associated gastritis was the most common form of chronic gastritis, without intestinal metaplasia and with mild activity. The association of h pylori with mild inflammation and Neutrophilic infiltrates of the lamina propria, pits, or surface epithelium was statistically significant (p value < 0.05). Conclusion: The frequency of H. pylori infection is common in our population but the infection is mild to moderate and its Sydney classification reveals that early diagnosis may prevent the later complication.

Helicobacter pylori, Sydney Classification, Histology, Gastritis

Soomro, S. , Mustansir, T. and Mirza, T. (2019) Histopathological Evaluation of Prevalent H. pylori Induced Gastro Intestinal Diseases According to Updated Sydney Classification. Journal of Biosciences and Medicines, 7, 195-201. doi: 10.4236/jbm.2019.75021.