Author(s)

Nabil Dib^1,2, Brad J. Martinsen³, Bynthia M. Anose³, John McB. Hodgson⁴, Robert Kohler², Georges Nseir⁵, Nathalie R. Antonios⁶, Richard Shlofmitz⁷, Jeffrey W. Chambers⁸

¹Cardiovascular Research and New Devices, Mercy Gilbert Medical Center, Gilbert, USA.
²International Society for Cardiovascular Translational Research, Phoenix, USA.
³Scientific Affairs, Cardiovascular Systems, Inc., St. Paul, USA.
⁴Technology Solutions Group, Moreland Hills, USA.
⁵Premier Cardiovascular Center, Dignity Health Chandler Hospital, Chandler, USA.
⁶Chicago Medical School, North Chicago, USA.
⁷Department of Cardiology, St. Francis Hospital, Heart Center, Roslyn, USA.
⁸Metropolitan Heart and Vascular Institute, Mercy Hospital, Minneapolis, USA.

The aim of this prospective observational pilot study was to observe the impact of orbital atherectomy (OA) on the coronary microcirculation via coronary flow reserve (CFR) measurements. Fifteen subjects who had successful OA and stent placement with no procedural complication were enrolled at 3 hospitals in the U.S. Baseline and hyperemic velocities were 16 ± 5.2 and 36 ± 14 cm/sec, respectively. The average CFR post-procedure was within the normal range at 2.23 ± 0.33. The observation of normal CFR following OA may be attributed to the orbital action of the device that allows for continuous flow during treatment, minimizing a bolus embolization effect which can impact microvascular function.

Percutaneous Coronary Intervention, Microvascular Function, Orbital Atherectomy, Calcified Lesions, Coronary Flow Reserve

Dib, N. , Martinsen, B. , Anose, B. , Hodgson, J. , Kohler, R. , Nseir, G. , Antonios, N. , Shlofmitz, R. and Chambers, J. (2019) Coronary Flow Reserve Assessment of Orbital Atherectomy: An Observational Pilot Study. Journal of Biomedical Science and Engineering, 12, 269-275. doi: 10.4236/jbise.2019.124019.