Kanggan Granule Ameliorates Dexamethasone-Induced Immunosuppression in Mice - Journal of Biosciences and Medicines

JBM > Vol.7 No.3, March 2019

Kanggan Granule Ameliorates Dexamethasone-Induced Immunosuppression in Mice ()

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DOI: 10.4236/jbm.2019.73008 593 Downloads 1,230 Views Citations

Author(s)

Yumiao Gan¹, Manxia Gu¹, Dongling Liu¹, Hongjing Zhou¹, Chenye Zeng¹, Tingting Yang¹, Hui Li¹, Funeng Geng², Junrong Du^1*

Affiliation(s)

¹Department of Pharmacology, West China School of Pharmacy, Key Laboratory of Drug Targeting and Drug Delivery System, Sichuan University, Chengdu, China.
²Sichuan Engineering Research Center for Medicinal Animals, Chengdu, China.

ABSTRACT

Objective: This study was to investigate the effect of the Chinese herbal compound Kanggan granule (KG) on immune function in a mouse model of immunosuppression and its possible mechanism of action. Method: ICR mice were randomly divided into a normal control group (untreated non-immunosuppressed, Control), untreated immunosuppressed group (Model), positive control group (immunosuppressed and treated with 1.6 g/kg astragalus granule [AG]), high-dose KG group (immunosuppressed and treated with 24 g/kg, KG-24), and low-dose KG group (immunosuppressed and treated with 6 g/kg, KG-6). Each group received intragastric administration once daily for 7 days. Immunosuppression was induced by an intraperitoneal injection of dexamethasone (25 mg/kg) once daily beginning on day 1 for 3 days. To illuminate the mechanism of immunomodulatory, we studied the effects of KG on nonspecific immunity, humoral immunity and cellular immunity in mice respectively. Results: KG improved organ weights and improved the phagocytic ability of mononuclear macrophages in immunosuppressed mice (p < 0.01 or p < 0.05). The proliferation of spleen lymphocytes and number of peripheral blood leukocytes were enhanced after KG treatment in immunosuppressed mice (p < 0.05). KG increased the CD4⁺/CD8⁺ ratio in immunosuppressed mice (p < 0.01) and increased serum IL-2 and IgG levels (p < 0.01). Conclusions: KG can improve immune function in immunosuppressed mice. Nonspecific immunity, humoral immunity, and cellular immunity were all enhanced.

KEYWORDS

Kanggan Granule, Immunomodulatory, Nonspecific Immunity, Humoral Immunity, Cellular Immunity

Share and Cite:

Gan, Y. , Gu, M. , Liu, D. , Zhou, H. , Zeng, C. , Yang, T. , Li, H. , Geng, F. and Du, J. (2019) Kanggan Granule Ameliorates Dexamethasone-Induced Immunosuppression in Mice. Journal of Biosciences and Medicines, 7, 80-91. doi: 10.4236/jbm.2019.73008.

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