Author(s)

Fatoumata Matokoma Sidibe¹, Hajar Ouahbi¹, Rajae Kanab¹, Layla Tahiri², Fatim Zhara El Mrabet¹, Samia Arifi¹, Hind El Fatemi², Nawfel Mellas¹

¹Medical Oncology Department, HASSAN II University Hospital, Fez, Morocco.
²Pathology Department, HASSAN II University Hospital, Fez, Morocco.

Primary Ewing sarcoma (ES) and primitive neuroectodermal tumor (PNET) are considered as Ewing sarcoma family of tumors (ESFT), characterized by chromosomal translocation t(11; 22) (q24; q12) leading to a chimeric transcript EWS-FLI1 in 85% of cases. It typically involves the soft tissues of the chest wall, pelvis, paravertebral region, abdominal wall, retroperitoneal region and extremities in children, adolescents and young adults. It rarely occurs in the female genital tract. We report an extremely rare case of advanced vulvar Ewing sarcoma/PNET of the vulva confirmed by Fluorescence In Situ Hybridization (FISH) in a 30-year-old woman. The patient was treated by 6 cycles of chemotherapy followed by radiotherapy with favourable outcome.

Ewing Sarcoma/Primitive Neuroectodermal Tumor, Vulva, Advanced Disease, Multimodal Treatment

Sidibe, F. , Ouahbi, H. , Kanab, R. , Tahiri, L. , Mrabet, F. , Arifi, S. , Fatemi, H. and Mellas, N. (2018) Primary Vulvar Ewing Sarcoma in a 30-Year-Old Woman: A Case Report. Case Reports in Clinical Medicine, 7, 241-248. doi: 10.4236/crcm.2018.73022.