Author(s)

James Ajeck Mbah^1*, Godfred Aponglen Ayimele¹, Norbert Kodjio², Joseph Ngwain Yong¹, Emmanuel Ngwang Nfor¹, Donatien Gatsing²

¹Department of Chemistry, University of Buea, Buea, Cameroon.
²Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.

A novel ligand, 1-(4-methoxybenzylidene)-4-methylthiosemicarbazone (MBT) derived from 4-methoxybenzaldehyde was synthesized and characterized by spectroscopic methods (IR, ¹H NMR, ¹³C NMR), single crystal X-ray diffraction technique and physical means. MBT showed antibacterial activity in vitro with MICs of 64 μg/mL (a strain of Salmonella typhi (ATCC 6539)), 128 μg/mL (Salmonella typhi), 64 μg/mL (Salmonella paratyphi A), 128 μg/mL (Salmonella paratyphi B) and 64 μg/mL (Salmonella typhimurium). The results showed that MBT demonstrated moderate in vitro antibacterial activity against a strain of Salmonella typhi (ATCC 6539), Salmonella paratyphi A, and Salmonella typhimurium, indicating its promise as a possible lead for the discovery of antibacterial drugs.

Novel Schiff Base, Antibacterial Activity, Crystal Structure

Mbah, J. , Ayimele, G. , Kodjio, N. , Yong, J. , Nfor, E. and Gatsing, D. (2017) Synthesis, Molecular Structure and Antibacterial Activity of 1-(4-Methoxybenzaldehyde)-4-Methylthiosemicarbazone. International Journal of Organic Chemistry, 7, 229-239. doi: 10.4236/ijoc.2017.73017.