This paper presents the tire pressure monitoring system (TPMS) by using the system on chip (SoC) mixed signals with the help of Bluetooth transmission and in advantage of low power consumption design. This is to monitor the variations in temperature and pressure of the vehicle’s tire, and the TPMS system is involved. It improves the driver’s safety by automatically detecting the tire pressure and temperature and then warning signal is sent to driver to take a measure, which prevents from accident. The proposed system of tire pressure monitoring system using SoC increases the speed of indication time to the driver by using mixed signals. The inflation of the tire can be avoided by preventing from high temperature and high pressure. Limitation of temperature and pressure in the previous system is also elongated i.e. temperature from 40℃ to 125℃ and pressure from 0 to 750 Kpa. Sensors, wireless communication (Bluetooth dongle) and SoC unit are used to design the low power TPMS. Quantitative results are taken and the analogy between temperature and pressure is also verified. The tested results proved by need of the practical system. Signal conditioning voltage and SoC unit is the trace for low power design TPMS. Finally, the performance of the system is tested and executed by using proteus software given as a real time application.