Author(s)

Hasanuddin  ¹, K. Sofie Rifayani^2*, G. Supriadi², Dikdik Kurnia³, D. Adhita⁴

¹Department of Obstetric and Gynecology, Medical Faculty of Syiah Kuala University/Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia.
²Department of Obstetric and Gynecology, Medical Faculty of Padjadjaran University/Dr. Hasan Sadikin Hospital, Bandung, Indonesia.
³Department of Chemistry, Faculty of Mathematic and Natural Science, Padjadjaran University, Bandung, Indonesia.
⁴Department of Conservative Dentistry, Faculty of Dentistry, Padjadjaran University, Bandung, Indonesia.

Objectives: The purpose of this study was to determine anticancer activity of terpenoid bioactive compound isolated from Papua ant nest on ovarian cancer cells in vitro. Methods: This was a laboratory experimental study which aims to determine the potential of the terpenoid bioactive compound isolated from Papua ant nest to inhibit the growth and induce apoptotic process on ovarian cancer cells (SKO-3) in vitro. Result: Terpenoid had capability to inhibit the growth of ovarian cancer cell line (SKO-3) in vitro, with IC₅₀ of 481 ug/ml at 48 hours and 463 ug/ml at 48 hours, respectively. At a concentration of 600 ug/ml, terpenoid was able to induce apoptotic process on ovarian cancer cell lines in vitro with the apoptotic index of 30% at 24 hours, 35% at 48 hours and 37% at 72 hours, respectively. Conclusion: Terpenoid bioactive compound isolated from Papua ant nest had the ability to inhibit the growth and was able to induce apoptotic process on ovarian cancer cell lines (SKO-3) in vitro.

Terpenoid, Ovarian Cell Lines, Apoptotic Index

Hasanuddin, Rifayani, K., Supriadi, G., Kurnia, D. and Adhita, D. (2015) Potential of Terpenoid Bioactive Compound Isolated from Papua Ant Nest as an Alternative Ovarian Cancer Treatment. Open Journal of Obstetrics and Gynecology, 5, 406-411. doi: 10.4236/ojog.2015.57058.