Since Socrates memory has always been an intriguing matter. To date for the common run of people being hit by Alzheimer’s disease (AD) is “memory loss with no hope of return”. Looking at the brain matter as an ordered closed system where memory and cognition information are located, according to Loschmidt Paradox, and thermodynamically speaking, it should be possible for AD patient brains presenting severe cognitive impairments (disordered state), to move backward to the original brain ordered state. This assumption based on thermodynamic concepts may appear inconsistent with current knowledge in neurosciences on “memory and its operation”. Attempts to connect neurobiological science to quantum physics concepts may allow a breakthrough in the understanding of memory function and therefore a step ahead in the knowledge of how memory works.