Author(s)

Vahid Yousefi Babadi, Leyla Sadeghi, Esmaiel Amraie, Mohammad Rezaei, Ali Akbar Malekirad, Meghdad Abarghouei Nejad

Department of Biochemistry, Faculty of Biological Science, Tarbiat Modares University, Tehran, Iran.
Department of Biology, Faculty of Sciences, Payam Noor University, Iran;.
Department of Food Safety and Hygiene, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Meghdad.abarghouei.nejad@gmail.com.
Payam Noor University, Iran.
Physiology Research Center, Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.

Manganese is an essential metal in human that functions in many enzymes. In contrast excessive exposure to Mn results in neurotoxicity. Accumulation of manganese damages central nervous system and causes Parkinson disease like syndrome called manganism. Mn neurotoxicity has been suggested to involve an imbalance in catecholamine neurotransmitters. It hypothesized that Mn can obstruct catecholamine synthesis pathway by inhibition of Tyrosine hydroxylase. Previous studies demonstrated that chronic and acute dose of Mn has different possible effects on catecholamine synthesis. It’s assumed that an acute dose of manganese can kill dopaminergic cells. Therefore, we focused the effect of Mn in catecholamine concentration on the rat’s brain by MnCl₂ injection intraperitoneally and analyzed their brains after the time interval. This study used different acute doses in short time courses and different chronic doses at different exposing times to investigate which of them (exposing dose or time) is more important in Mn toxic effect. Measurement of catecholamine concentration performed by fluorescence assay in acidic and oxidant environment.

 

Manganese; Neurotoxicity; Catecholamine; Toxicology

Babadi, V. , Sadeghi, L. , Amraie, E. , Rezaei, M. , Malekirad, A. and Nejad, M. (2013) Manganese toxicity in the central nervous system: Decreeing of catecholamine in rat’s brains. Health, 5, 2146-2149. doi: 10.4236/health.2013.512292.