This paper applied the safety reliability of food cold chain logistics to establish reliability allocation model for cold chain systems, designed optimization algorithms, and made a case analysis. By applying system reliability allocation principle, this article firstly built safety reliability allocation model of food cold chain logistics system without cost constraint based on the safety reliability model of food cold chain logistics system, and then it set up optimal decision- making model of food cold chain logistics system with cost constraint using the functional relationship between the time, temperature of cold chain logistics and logistics costs. Next, according to the characteristics of the model, a heuristic algorithm was proposed to allocate safety reliability of the system to each cold chain unit so as to achieve the goal of operatingcosts optimization subject to assurance ofoverall safety reliability of the cold chain system. Taking the safety impact factor of food cold chain unit as a weight, the article also deduced the equation of reallocation of safety reliability of food cold chain system. In the end, these models were used to optimize the allocation of safety reliability in an example of Sushi cold chain process. It provided a new thought and method to optimally plan the unit safety of food cold chain system as well as reduce the cost of food cold chain.