Respiratory Morbidity Associated with Long-Term Occupational Inhalation Exposure to High Concentrations of Hydrated Calcium Sulfate Dust

Abstract

Despite wide application of hydrated calcium sulfate, possible respiratory effects of long-term occupational exposure to high concentrations of this chemical have only been investigated in a limited number of epidemiological studies. This study is undertaken to examine this issue, more thoroughly. This cross-sectional study is carried out at a local gypsum plant in Shiraz, capital of Fars province situated in south western Iran. All exposed subjects (20 male workers) and 20 healthy non-exposed male individuals as the referent group are investigated. Prevalence of respiratory symptoms among the studied subjects is evaluated and they undergo spirometry test (twice for the exposed group and once for the unexposed employees). Moreover, to assess the extent to which workers are exposed to gypsum dust and using standard methods, inhalable and respirable fractions of this compound are measured in different dusty worksites. Average airborne concentration of inhalable dust fraction is estimated to be 24 ± 14.76 mg/m3 which is higher than the recommended threshold limit value (TLV) for this chemical. Respiratory symptoms such as phlegm, wheezing and dyspnea are significantly more prevalent in exposed subjects than in non-exposed employees (p < 0.05). The results of ventilatory function tests (pre- shift) don’t show any significant differences between both groups. However, some post-shift parameters of ventilatory function such as FVC, FEV1 and FEV1/FVC ratio are significantly lower than those of preshift and referent group. Exposure to high atmospheric concentrations of gypsum dust is associated with a significant increase in the prevalence of respiratory symptoms along with acute reversible significant decreases in some parameters of ventilatory function.

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Neghab, M. , Toosi, S. and Azad, P. (2016) Respiratory Morbidity Associated with Long-Term Occupational Inhalation Exposure to High Concentrations of Hydrated Calcium Sulfate Dust. Occupational Diseases and Environmental Medicine, 4, 1-7. doi: 10.4236/odem.2016.41001.

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1] Reed, A.H. (1975) Gypsum. By the Staff, Mineral Facts and Problems, Vol. 667, Bureau of Mines, Washington, 469- 477.
[2] Stellman, J.M. (1998) Chemicals; Industries and occupations, in Encyclopedia of Occupational Health and Safety. Chapter 62, Intemational Labour Organization, Geneva.
[3] TOXNET (2005) Calcium Sulphate Dihydrate.
[4] Baxter, P.J., et al. (2010) Other Non-Fibrous Mineral Dust, in Hunter’s Diseases of Occupations. Taylor and Francis Group, CRC Press, London, 1324.
[5] NIOSH (2005) Undated-C. NPGD0308-NIOSH Pocket Guide to Chemical Hazards. Gypsum [CAS 13397-24-5]. http://www.cdc.gov/niosh/npg/npgd0308.html
[6] Collis, E.L. (1931) Occupational Dust Diseases, Bull. Hyg.: Lond.
[7] (2006) Chemical Information Review Document for Synthetic and Naturally Mined Gypsum (Calcium Sulfate Dihydrate) [CAS No. 13397-24-5], I. Integrated Laboratory Systems, N. Research Triangle Park, and U.C.N. N01-ES- 35515, Editors. National Toxicology Program.
[8] Bethesda, M. (1991) The Hazardous Substances Data Bank: Calcium Sulfate. N. L. O. Medicine [NLM].
[9] Genium (1990) Material Safety Data Sheet. G.P. Corporation, Schenectady.
[10] Parmeggiani, L. (1983) Encyclopedia of Occupational Health and Safety. 3rd Edition, Geneva, International Labour Organization (ILO).
[11] TOXNET (1989) Calcium Sulphate. http://www.toxnet.nlm.nih.gov
[12] Gordon, B.L., et al. (Eds.) Clinical Cardiopulmonary Physiology. In: Gordon, B.L. and Kory, R.C., Eds., Clinical Cardiopulmonary Physiology, Grune & Stratton, New York, 350.
[13] Voropaev, A.A. (1967) Major Problems of Industrial Hygiene in Production of Construction Gypsum (Hygienic, Clinical and Experimental Investigations). Gigiena Truda i Professional’nye Zabolevaniia, 11, 23-26.
[14] Feil, A. (1951) Cement Dust and Pulmonary Tuberculosis. Le Médecin d’Usine; Revue d’Hygiène Industrielle et des Maladies Professionnelles, 13, 272.
[15] Gardner, L.U. (1934) Silicosis and Its Relationship to Tuberculosis. American Review of Tuberculosis, 29, 1-7.
[16] Oakes, D., Douglas, R., Knight, K., Wusteman, M. and McDonald, J.C. (1982) Respiratory Effects of Prolonged Exposure to Gypsum Dust. The Annals of Occupational Hygiene, 26, 833-840.
http://dx.doi.org/10.1093/annhyg/26.8.833
[17] Minstry of Industry (2012) Mining and Trade. www.mimt.gov.ir/
[18] Sanaei, G.H. Industrial Toxicology. Vol. 1. 1385: Tehran University, Tehran.
[19] World Medical Association Declaration of Helsinki: Ethical Principles for Medical Research Involving Human Subjects. Adopted by the 18th General Assembly, Helsinki, June 1964.
http://www.wma.net/en/30publications/10policies/b3/17c.pdf
[20] Ferris, B.G. (1978) Epidemiology Standardization Project (American Thoracic Society). The American Review of Respiratory Disease, 118, 1-120.
[21] American Thoracic Society (1979) ATS Statement—Snowbird Workshop on Standardization of Spirometry. The Ame- rican Review of Respiratory Disease, 119, 831-880.
[22] Neghab, M., HabibiMohraz, M. and Hassanzadeh, J. (2011) Symptoms of Respiratory Disease and Lung Functional Impairment Associated with Occupational Inhalation Exposure to Carbon Black Dust. Occupational Health, 53, 432- 438. http://dx.doi.org/10.1539/joh.11-0083-OA
[23] NIOSH (1984) Nuisance Dust, Respirable: Method 0600. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health[NIOSH], Cincinnati, 84- 100.
[24] American Conference of Governmental Industrial Hygienists (ACGIH) (2009) Threshold Limit Values for Chemical Substances and Physical Agents and Biological Exposure Indices. ACGIH, Cincinnati.
[25] Ghasemkhani, M., Kumashiro, M., Rezaei, M., Anvari, A.R., Mazloumi, A. and Sadeghipour, H.R. (2006) Prevalence of Respiratory Symptoms among Workers in Industries of South Tehran, Iran. Industrial Health, 44, 218-224. http://dx.doi.org/10.2486/indhealth.44.218
[26] (2013) Miscellaneous Gypsum Products. National Gypsum Company, Charlotte.
[27] Burilkov, T. and Michailova-Dotschewa, L. (1990) Dangers of Exposure to Dust Extraction and Production of Natural Gypsum. Wiss Umwelt, 2, 89-91. Abstract from EMBASE 91094689.
[28] Einbrodt, H.J. (1988) The Health Risks by Dusts of Calcium Sulfate (Ger.). Wiss Umwelt, 4, 179-181. Abstract from EMBASE 89261036.
[29] Clouter, A., Houghton, C.E., Bowskill, C.A., Hoskins, J.A. and Brown, R.C. (1996) An in Vitro/in Vivo Study into the Short-Term Effects of Exposure to Mineral Fibers. Experimental and Toxicologic Pathology, 48, 484-486. http://dx.doi.org/10.1016/S0940-2993(96)80061-3
[30] Ramazzini, B. (1703) De morbis artificum diatriba. 2nd Edition, Guilielmus van de Water, Ultrajecti, 62.

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