Prof. Feng Chen
Department of Forensic Medicine
Nanjing Medical University, China
Professor
Email: fchen@njmu.edu.cn
Qualifications
2011 Ph.D., Forensic medicine, Xi’an
Jiaotong University, China
2005 M.D., Forensic medicine,
Xi’an Jiaotong University, China
Research Fields
Forensic Medicine
Human Genetics
Vascular disease
Publications
(selected)
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Chen F, Barman S, Yu Y, Haigh S, Wang
Y, Dou H, Bagi Z, Han W, Su Y, Fulton DJ. Caveolin-1 is a negative regulator
of nadph oxidase-derived reactive oxygen species. Free Radic Biol Med.
2014;73:201-213.
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Barman SA, Chen F, Su Y,
Dimitropoulou C, Wang Y, Catravas JD, Han W, Orfi L, Szantai-Kis C, Keri G,
Szabadkai I, Barabutis N, Rafikova O, Rafikov R, Black SM, Jonigk D, Giannis A,
Asmis R, Stepp DW, Ramesh G, Fulton DJ*. Nadph oxidase 4 is expressed in
pulmonary artery adventitia and contributes to hypertensive vascular
remodeling. Arterioscler Thromb Vasc Biol. 2014;34:1704-1715.
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Qian XQ, Yin CY, Ji Q, Li K, Fan HT,
Yu YF, Bu FL, Hu LL, Wang JW, Mu HF, Haigh S, Chen F. Mutation Rate Analysis
at 19 Autosomal Microsatellites. Electrophoresis. 2015 Mar 27. doi:
10.1002/elps.201400558. [Epub ahead of print].
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Yin CY, Ji Q, Li K, Mu HF, Zhu BF,
Yan JW, Yu YF, Wang JW, Chen F. Analysis of 19 str loci reveals genetic
characteristic of eastern chinese han population. Forensic Science
International:Genetics. 2015, 14: 108–109.
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Chen F, Yin CY, Qian XQ, Fan HT, Deng
YJ, Zhang YD, Meng HT, Shen CM, Yang CH, Jin R, Zhu BF, Xu P.Single nucleotide
polymorphisms of mitochondrial DNA HVS-I and HVS-II in Chinese Bai ethnic
group. Electrophoresis. 2015 Mar;36(6):930-6.
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Chen F, Yu Y, Haigh S, Johnson J,
Lucas R, Stepp DW, Fulton DJ. Regulation of nadph oxidase 5 by protein kinase
c isoforms. PLoS One. 2014;9:e88405.
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Li K, Muhetebaier M, Wang JW, Xie SM,
Zhang K, Tang W, Chen F. Medical legal dispute in hospitals of different grades:
a retrospective study on 206 cases. Fa Yi Xue Za Zhi. 2014 Oct;30(5):355-6.
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Chen F, Kumar S, Yu Y, Aggarwal S,
Gross C, Wang Y, Chakraborty T, Verin AD, Catravas JD, Lucas R, Black SM,
Fulton DJ. Pkc-dependent phosphorylation of enos at t495 regulates enos
coupling and endothelial barrier function in response to g+ -toxins. PLoS One.
2014;9:e99823.
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Elms S#, Chen F#, Wang Y, Qian J,
Askari B, Yu Y, Pandey D, Iddings J, Caldwell RB, Fulton DJ. Insights into the
arginine paradox: Evidence against the importance of subcellular location of
arginase and enos. Am J Physiol Heart Circ Physiol. 2013;305:H651-666.
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Chen F, Yu Y, Qian J, Wang Y, Cheng B,
Dimitropoulou C, Patel V, Chadli A, Rudic RD, Stepp DW, Catravas JD, Fulton DJ.
Opposing actions of heat shock protein 90 and 70 regulate nicotinamide adenine
dinucleotide phosphate oxidase stability and reactive oxygen species
production. Arterioscler Thromb Vasc Biol. 2012;32:2989-2999.
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Chen F, Pandey D, Chadli A, Catravas
JD, Chen T, Fulton DJ. Hsp90 regulates nadph oxidase activity and is necessary
for superoxide but not hydrogen peroxide production. Antioxid Redox Signal.
2011;14:2107-2119.
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Chen F, Fulton DJ. An inhibitor of
protein arginine methyltransferases,
7,7'-carbonylbis(azanediyl)bis(4-hydroxynaphthalene-2-sulfonic acid (ami-1), is
a potent scavenger of nadph-oxidase-derived superoxide. Mol Pharmacol.
2010;77:280-287.
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Cheng B, Anea CB, Yao L, Chen F, Patel
V, Merloiu A, Pati P, Caldwell RW, Fulton DJ, Rudic RD. Tissue-intrinsic
dysfunction of circadian clock confers transplant arteriosclerosis. Proc Natl
Acad Sci U S A. 2011;108:17147-17152.
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Chen F, Haigh S, Barman S, Fulton DJ.
From form to function: The role of nox4 in the cardiovascular system. Front
Physiol. 2012 Nov 1;3:412.
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Chen F, Lucas R, Fulton D. The
subcellular compartmentalization of arginine metabolizing enzymes and their
role in endothelial dysfunction. Front Immunol. 2013 Jul 9;4:184. PMID:
23847624, PMCID: PMC3705211.
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Mu HF, Xu D, Liu B, Huang YQ, Wang LN,
Zhang B, Chen F*. [mutation of suspected autosomal str loci: 227 cases
retrospective analysis]. Fa Yi Xue Za Zhi. 2013;29:196-198 PMID:24303763.
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Chen F, Chen Y, Yu Y, Qiang Y, Liu M,
Fulton D, Chen T. Age and sex related measurement of craniofacial soft tissue
thickness and nasal profile in the chinese population. Forensic Sci Int.
2011;212:272 e271-276.
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Chen F, Deng Y, Dang Y, Zhang B, Mu H,
Yu X, Li L, Yan C, Chen T. Genetic polymorphism of mitochondrial DNA hvs-i and
hvs-ii of chinese tu ethnic minority group. J Genet Genomics. 2008;35:225-232.
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Chen F, Dang YH, Yan CX, Liu YL,
Deng YJ, Fulton DJ, Chen T. Sequence-length variation of mtdna hvs-i c-stretch
in chinese ethnic groups. J Zhejiang Univ Sci B. 2009;10:711-720.
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Pandey D, Chen F, Patel A, Wang CY,
Dimitropoulou C, Patel VS, Rudic RD, Stepp DW, Fulton DJ. Sumo1 negatively
regulates reactive oxygen species production from nadph oxidases. Arterioscler
Thromb Vasc Biol. 2011;31:1634-1642.
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Qian J, Chen F, Kovalenkov Y, Pandey
D, Moseley MA, Foster MW, Black SM, Venema RC, Stepp DW, Fulton DJ. Nitric
oxide reduces nadph oxidase 5 (nox5) activity by reversible s-nitrosylation.
Free Radic Biol Med. 2012;52:1806-1819.
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Ruan L, Torres CM, Qian J, Chen F,
Mintz JD, Stepp DW, Fulton D, Venema RC. Pin1 prolyl isomerase regulates
endothelial nitric oxide synthase. Arterioscler Thromb Vasc Biol.
2011;31:392-398.
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Anea CB, Zhang M, Chen F, Ali MI,
Hart CM, Stepp DW, Kovalenkov YO, Merloiu AM, Pati P, Fulton D, Rudic RD.
Circadian clock control of nox4 and reactive oxygen species in the vasculature.
PLoS One. 2013;8:e78626.
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Chen H, Ye H, Meng DQ, Cai PC, Chen F,
Zhu LP, Tang Q, Long ZX, Zhou Q, Jin Y, Xin JB, Tao XN, Ma WL. Reactive oxygen
species and x-ray disrupted spontaneous [ca(2)(+)]i oscillation in alveolar
macrophages. Radiat Res. 2013;179:485-492.
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Pandey D, Patel A, Patel V, Chen F,
Qian J, Wang Y, Barman SA, Venema RC, Stepp DW, Rudic RD, Fulton DJ. Expression
and functional significance of nadph oxidase 5 (nox5) and its splice variants
in human blood vessels. Am J Physiol Heart Circ Physiol. 2012;302:H1919-1928.
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Chen YJ, Liu YL, Zhong Q, Yu YF, Su
HL, Toque HA, Dang YH, Chen F, Xu M, Chen T. Tetrahydropalmatine protects
against methamphetamine-induced spatial learning and memory impairment in mice.
Neurosci Bull. 2012;28:222-232.
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Last Updated: 2015-07-06