Prof. R. Charles Nichols

University of Florida Proton Therapy Institute, USA

Email: rnichols@floridaproton.org

Qualifications

1988 M.D., Georgetown University Medical School

1983 B.A., Georgetown University College of Arts and Sciences

Publications (selected)

1. Nichols RC Jr, Huh SN, Prado KL, Yi BY, Sharma NK, Ho MW, Hoppe BS, Mendenhall NP, Li Z, Regine WF: Protons Offer Reduced Normal-Tissue Exposure for Patients Receiving Postoperative Radiotherapy for Resected Pancreatic Head Cancer. Int J Radiat Oncol Biol Phys. 2012 Jan 13. [Epub ahead of print] PMID: 22245197.
2. Mendenhall WM, Hoppe BS, Nichols RC Jr, Henderson RH, Mendenhall NP: When Is Elective Pelvic Lymph Node Irradiation Indicated in Definitive Radiotherapy for Localized Prostate Cancer?  Am J Clin Oncol. 2012 Jan 10. [Epub ahead of print] PMID: 22237149.
3. Hoppe B, Henderson R, Mendenhall WM, Nichols RC Jr, Li Z, Mendenhall NP: Proton therapy for prostate cancer: Oncology (Williston Park). 2011 Jun; 25(7):644-50, 652. Review PMID: 21888265.
4. Nichols RC Jr, Huh SH, Hoppe BS, Henderson RH, Li Z, Flampouri S, D'Agostino HJ, Cury JD, Pham DC, Mendenhall NP: Protons safely allow coverage of high-risk nodes for patients with regionally advanced non-small-cell lung cancer. Technol Cancer Res Treat. 2011 Aug; 10(4):317-22. PMID: 21728388.
5. Nichols RC Jr, Huh SN, Henderson RH, Mendenhall NP, Flampouri S, Li Z, D'Agostino HJ, Cury JD, Pham DC, Hoppe BS: Proton radiation therapy offers reduced normal lung and bone marrow exposure for patients receiving dose-escalated radiation therapy for unresectable stage III non-small-cell lung cancer: a dosimetric study. Clin Lung Cancer. 2011 Jul;12(4):252-7. doi: 10.1016/j.cllc.2011.03.027. Epub 2011 Apr 27. PMID: 21726825.
6. Mendenhall WM, Henderson RH, Hoppe BS, Nichols RC Jr, Mendenhall NP: Androgen Deprivation Therapy and Definitive Radiotherapy for Prostate Cancer. Am J Clin Oncol. 2011 Jun 18. [Epub ahead of print] PMID: 21694574.
7. Nichols RC Jr, Morris CG, Hoppe BS, Henderson RH, Marcus RB Jr, Mendenhall WM, Li Z, Williams CR, Costa JA, Mendenhall NP: Proton radiotherapy for prostate cancer is not associated with post-treatment testosterone suppression. Int J Radiat Oncol Biol Phys. 2012 Mar 1;82(3):1222-6. Epub 2011 May 11.PMID: 21570206.
8. Song WY, Huh SN, Liang Y, White G, Nichols RC Jr, Watkins WT, Mundt AJ, Mell LK: Dosimetric comparison study between intensity modulated radiation therapy and three-dimensional conformal proton therapy for pelvic bone marrow sparing in the treatment of cervical cancer. J Appl Clin Med Phys. 2010 Aug 15;11(4):3255. PMID: 21081882 [Pub Med - indexed for Medline].
9. Hoppe BS, Huh S, Flampouri S, Nichols RC Jr, Oliver KR, Morris CG, Mendenhall NP, Li Z: Double-scattered proton-based stereotactic body radiotherapy for stage I lung cancer: a dosimetric comparison with photon-based stereotactic body radiotherapy.  Radiother Oncol. 2010 Dec; 97(3):425-30. Epub 2010 Oct 9. PMID: 20934768
10. Mendenhall WM, Nichols RC Jr, Henderson R, Mendenhall NP: Is radical prostatectomy the *gold standard* for localized prostate cancer? Am J Clin Oncol. In press.
11. Mendenhall WM, Henderson RH, Nichols RC Jr, Keole SR, Mendenhall NP: Postprostatectomy radiotherapy for prostate cancer. Am J Clin Oncol. 2009 July 31[Epub ahead of print].
12. Zempolich K., Fuhrman C., Milash B, Flinner R, Greven K, Ryu J, Forbes A, Kerlin K, Nichols RC Jr, Gaffney DK: Changes in Gene Expression induced by Chemoradiation in Advanced Cervical Carcinoma: A Microarray study of RTOG C-0128. Gynecol Oncol. 2008 May:109(2):275-9. Epub 2008 Mar 4.
13. Mohiuddin M, Winter K, Mitchell E, Hanna N, Yuen A, Nichols RC Jr, Shane R, Hayostek C, Willet C: Randomized phase II study of Neoadjuvant combined-modality chemoradiation for distal rectal cancer: Radiation Therapy Oncology Group Trial 0012. Journal of Clinical Oncology. 2006 Feb 1; 24(4): 650-5.
14. Gaffney DK, Winter K, Fuhrman C, Flinner R, Greven K, Ryu J, Forbes A, Kerlin K, Nichols RC Jr, Zempolich K: Feasibility of RNA collection for micro-array gene expression analysis in the treatment of cervical carcinoma: a scientific correlate of RTOG C-0128. Gynecologic Oncology. 2005 May; 97(2):607-11.
15. Regine WF, Schmitt FA, Scott CB, Dearth C, Patchell RA, Nichols RC Jr, Gore EM, Franklin RL, Suh JH, Mehta MP: Feasibility of neurocognitive outcome evaluations in patients with brain metastases in a multi-institutional cooperative group setting: results of the Radiation Therapy Oncology Group trial BR-0018. International Journal of Radiation Oncology Biology and Physics. 2004 Apr 1; 58 (5): 1346-52.
16. Nichols RC Jr, Sweetser MG, Mahmood SK, Malamud FC, Dunn NP, Adams JP, Kyker JS, Lydick K: Radiation Therapy and Concomitant Paclitaxel/Carboplatin Chemotherapy for Muscle Invasive Transitional Cell Carcinoma of the Bladder: A Well-Tolerated Combination. Radiation Oncology Investigations 90, 281-286 (2000).
17. Fein DA, Nichols RC Jr, Lee WR, Mendenhall WM, Parsons JT, Stringer SP, Cassisi NJ, Million RR: T2-T3 Carcinoma of the Supraglottic Larynx: A Comparison of Surgery and Radiotherapy. Radiation Oncology Investigations 2:237-244 (1995).
18. Mohler ER, Sheridan MJ, Nichols R, Harvey WP, Waller BF: Development and progression of aortic valve stenosis: atherosclerosis risk factors--a causal relationship? A clinical morphologic study. Clinical Cardiology 1991 Dec:14(12):995-9.