Prof. Jean-Pierre
Louboutin
University
of West Indies, Jamaica
Email: jplouboutin@hotmail.com, jplouboutin@juno.com
Qualifications
1995 Ph.D.,
Cellular Physiology, University of Nantes, France
1987 M.D.,
Medical School, University of Nantes, France
1985 M.Sc.,
Human Biology, University of Nantes, France
Publications (Selected)
1. Hinderer, C., Bell, P., Louboutin, J.P., Zhu,
Y., Yu, H., Lin, G., Choa, R., Gurda, B.,
Bagel, J., O'Donnell, P., Sikora, T., Ruane, T., Wang, P., Tarantal, A., Casal,
M., Haskins, M., Wilson, J.M.: Neonatal systemic AAV induces tolerance to CNS
gene therapy in MPS I dogs and nonhuman primates. In press: Molecular Therapy.
IF: 6.4
2. Louboutin, J.P. HTLV-1-Associated
Myelopathy/Tropical Spastic Paraparesis: clinical presentation and
pathophysiology. In press: World Journal of Neurology. IF: N/A
3. Bell, P., Hinderer, C., Louboutin, JP.,
Yu, H., Grant, R., Bote, E., Wilson, JM.: Motor neuron transduction after
intracisternal delivery of AAV9 in a Cynomolgus macaque. Human Gene Therapy
Methods; 26: 43-44, 2015. IF: 3.6
4. Hinderer, C., Bell, P., Gurda, B.L., Wang,
Q., Louboutin, J.P., Zhu, Y., Bagel, J., O'Donnell, P., Sikora, T., Ruane,
T., Wang, P., Haskins, M.E., Wilson, J.M.: Liver-directed gene therapy corrects
cardiovascular lesions in feline mucopolysaccharidosis type I. Proceedings of
National Academy of Sciences U S A 111:14894-14899,2014. doi: 10.1073/pnas.1413645111.
IF: 9.8
5. Edwards, T.N., Louboutin, J.P.: Pathophysiology
of Tropical Spastic Paraparesis/HTLV-1-Associated Myelopathy: role of animal
models. International Journal of Neural Science and Brain Research; 1:3-5,2014.
IF: N/A
6. Edwards, T.N., Louboutin, J.P.: Hematopoietic
stem cell therapy and novel approaches for mucopolysaccharidoses. Journal of
Blood Disorders 1:6, 2014. IF: N/A
7. Louboutin, J.P., Strayer, D.S: Role of
oxidative stress in HIV-1-Associated Neurocognitive Disorder and protection by
gene delivery of antioxidant enzymes. Antioxidants 3:770-797,2014. doi:10.3390/antiox3040770.
IF: N/A
8. Hinderer, C., Bell, P., Vite, C.,
Louboutin, J.P., Grant, R., Bote, E., Yu, H., Pukenas, B., Hurst, R., Wilson,
J.M.: Widespread and safe gene transfer in the Central Nervous System of
Cynomolgus Macaques following delivery
of AAV9 into the cisterna magna. Molecular Therapy- Methods and Clinical
Development 1: 14051,2014. doi:10.1038/mtm.2014.51. IF: N/A
9. Hinderer, C., Bell, P., Gurda, B.L.,Wang,
Q., Louboutin, J.P., Bagel, J., O’Donnell, P., Sikora, T., Ruane, T., Wang, P.,
Haskins, M.E., Wilson, J.M.: Intrathecal gene therapy corrects CNS pathology in
a feline model of mucopolysaccharidosis I. Molecular Therapy , 2014. doi:10.1038/mt.2014.135.
IF: 6.4
10. Louboutin, J.P., Agrawal, L., Reyes,
B.A.S., van Bockstaele, E.J., Strayer, D.S.: Oxidative stress is associated
with neuroinflammation in animal models of HIV-1 Tat neurotoxicity. Antioxidants
3: 414-438, 2014. doi:10.3390/antiox3020414. IF: N/A
11. Louboutin, J.P., Strayer, D.S.: Relationship
between the chemokine receptor CCR5 and microglia in neurological disorders:
consequences of targeting CCR5 on neuroinflammation, neuronal death and
regeneration in a model of epilepsy. CNS Neurol Disord Drug Targets 12:
815-829, 2013. IF: 3.8
12. Kang, S., Louboutin, J.P., Datta, P.,
Landel, C.P., Martinez, D., Zervos, A.S., Strayer, D.S., Fernandes.Alnemri.,
T., Alnemri, E.S.: Loss of HtrA2/Omi activity in non-neuronal tissues of adult
mice causes premature aging. Cell Death Differentiation, 2012 20:
259-269. IF: 8.2
13. Louboutin, J.P., Agrawal, L., Reyes,
B.A.S., van Bockstaele, E.J., Strayer, D.S.: Gene delivery of antioxidant
enzymes inhibits HIV-1 gp120-induced expression of caspases. Neuroscience
214:68-77, 2012. IF: 3.1
14. Louboutin, J.P., Marusich, E., Gao, E.,
Agrawal, L., Koch, W.J., Strayer, D.S.: Ethanol protects from injury due to
ischemia and reperfusion by increasing vascularity via vascular endothelial
growth factor. Alcohol 46:441-454, 2012. IF: 2.4
15. Louboutin, J.P., Strayer, D.S.: Blood-Brain
Barrier abnormalities caused by HIV-1 gp120: Mechanistic and therapeutic
implications. The Scientific World Journal, 2012: 482575, 2012. IF: 1.7
16. Agrawal, L., Louboutin, J.P., Reyes,
B.A.S., van Bockstaele, E.J., Strayer, D.S.: HIV-1 Tat neurotoxicity: a model
of acute and chronic exposure, and neuroprotection by gene delivery of
antioxidant enzymes. Neurobiology of Disease 45: 657-670, 2012. IF: 5.6
17. Louboutin, J.P., Reyes, B.A.S., Agrawal,
L., van Bockstaele, E.J., Strayer, D.S.: Intracisternal rSV40 administration
provides effective pan-CNS transgene expression. Gene Therapy 19:114-118, 2012.
IF: 4.8
18. Louboutin, J.P., Reyes, B.A.S., Agrawal,
L., van Bockstaele, E.J., Strayer, D.S.: HIV-1 gp120 upregulates matrix
metalloproteinases and their inhibitors in a rat model of HIV encephalopathy.
European Journal of Neuroscience 34:2015-23, 2011. IF: 3.8
19. Louboutin, J.P., Chekmasova, A.A., Reyes,
B.A.S., van Bockstaele, E.J., Strayer, D.S.: Bone marrow-derived cells migrate
to line the vessels of the CNS: opportunities for gene delivery to CNS
vasculature. Neuroscience 10:195:215-223, 2011. IF: 3.1
20. Wang, L., Louboutin, J.P., Bell, P., Li,
Y., Wu, D., Wilson, J.M.: Muscle-directed gene therapy for hemophilia B with
more efficient and less immunogenic AAV vectors. Journal of haemostasis and
thrombosis 9:2009-2019, 2011. IF: 6.1
21. Marusich, E., Louboutin, J.P., Chekmasova,
A.A., D., Strayer, D.S.: Lymphocyte adhesion to CCR5 ligands is reduced by
anti-CCR5 gene delivery. Journal of Neurological Sciences 308:25-27, 2011. IF:
2.3
22. Louboutin, J.P., Marusich, E.,
Fisher-Perkins, J., Dufour, J., Bunnell, B.A., Strayer, D.S.: Gene transfer to
the Rhesus monkey brain using SV40-derived vectors is durable and safe. Gene
Therapy 18:682-691, 2011. IF: 4.8
23. Louboutin, J.P., Chekmasova, A.A.,
Marusich, E., Agrawal, L., Strayer, D.S.: Role of CCR5 and its ligands in the
control of vascular inflammation and leukocyte recruitment required for acute
excitotoxic seizure induction and neural damage. The FASEB Journal 25:737-53,
2011. IF: 5.7
24. Louboutin, J.P., Chekmasova, A.A.,
Marusich, E., Chowdhury, J.R., Strayer, D.S.: Efficient CNS gene delivery by
intravenous injection. Nature Methods 7:905-907, 2010. IF: 23.6
25. Louboutin, J.P., Reyes, B.A.S., Agrawal,
L., van Bockstaele, E.J., Strayer, D.S.: Gene transfer to the cerebellum. The
Cerebellum 9:587-597, 2010. IF: 2.6
26. Louboutin, J.P., Agrawal, L., Reyes,
B.A.S., van Bockstaele, E.J., Strayer, D.S.: HIV-1 gp120-induced injury to the
blood-brain barrier: role of metalloproteinases 2 and 9 and relationship to
oxidative stress. Journal of Neuropathology and Experimental Neurology
69:801-816, 2010. IF: 4.4
27. Louboutin, J.P., Reyes, B.A.S., Agrawal,
L., van Bockstaele, E.J., Strayer, D.S.: Blood-brain barrier abnormalities
caused by exposure to HIV-1 gp120- Protection by gene delivery of antioxidant
enzymes. Neurobiology of Disease 38:313-325, 2010. IF: 5.6
28. Louboutin, J.P., Reyes, B.A.S., Agrawal,
L., van Bockstaele, E.J., Strayer, D.S.: HIV-1 gp120-induced neuroinflammation:
relationship to neuron loss and protection by rSV40-delivered antioxidant
enzymes. Experimental Neurology 221:231-245, 2010. IF: 4.6
29. Mueller, C., Strayer, M.S., Sirninger, J.,
Braag, S., Branco, F., Louboutin, J.P., Flotte, T.R., Strayer, D.S.: In vitro
and in vivo functional characterization of gutless recombinant SV40-derived
CFTR vectors. Gene Therapy 17:227-237, 2010. IF: 4.8
30. Agrawal, L., Louboutin, J.P., Marusich, E.,
Reyes, B.A.S., van Bockstaele, E.J., Strayer, D.S.: Dopaminergic neurotoxicity
of HIV-1 gp120: reactive oxygen species as signaling intermediates. Brain
Research 1306:116-130, 2010. IF: 2.5
31. Louboutin, J.P., Agrawal, L., Reyes,
B.A.S., van Bockstaele, E.J., Strayer, D.S.: HIV-1 gp120 neurotoxicity
proximally and at a distance from the point of exposure: protection by rSV40
delivery of antioxidant enzymes. Neurobiology of Disease 34:462-476, 2009. IF:
5.6
32. Louboutin, J.P., Agrawal, L., Reyes,
B.A.S., van Bockstaele, E.J., Strayer, D.S.: A rat model of human immunodeficiency virus-1 encephalopathy using envelope
glycoprotein gp120 expression delivered by SV40 vectors. Journal of
Neuropathology and Experimental Neurology 68:456-473, 2009. IF: 4.3
33. Louboutin, J.P., Agrawal, L., Liu, B.,
Strayer, D.S.: In vivo gene transfer to the CNS using recombinant SV40-derived
vectors. Expert Opinion in Biological Therapy 8:1319-1335, 2008. IF: 3.2
34. Louboutin, J.P., Agrawal, L., Reyes,
B.A.S., van Bockstaele, E.J., Strayer, D.S.: Protecting neurons from HIV-1
gp120-induced oxidant stress using both localized intracerebral and generalized
intraventricular administration of antioxidant enzymes delivered by
SV40-derived vectors. Gene Therapy 14:1650-1661, 2007. IF: 4.8
35. Zhang, Z., Reenstra, W., Weiner, D.J.,
Louboutin, J.P., Wilson, J.M.: p38 MAPK signaling pathway is coupled to TLR5 to
mediate gene regulation in response to Pseudomonas aeruginosa infection in
human airway epithelial cells. Infection Immunity 75:5985-5992, 2007. IF: 4.2