Prof. Xuanyong Lu

Institute of Hepatitis and Virus Research, USA

Email: xuanyong.lu@Drexelmed.edu

Qualifications

1989 Ph.D., Goettingen University, Virology

1982 B.Sc., Nanjing University, Biochemistry

Publications(Selected)

1. Pamela Norton, Gong Q. Mehta A, Lu X and Block T. Hepatisis B Virus-mediated changes of apolipaprotein mRNA abundance in cultured hepatoma cells. J. Virol 77(9) 5503-5506.2003.
2. Xuanyong Lu, Trang Tran, Ender Semick and Timothy Block. The alkylated imino sugar,n- (n-nonyl)-deoxygalactonojirimycin, reduces the amount of hepatitis B virus (HBV) nucleocapsid in tissue culture. J. Virol. 77 (22), 11933-11940. 2003.
3. Xuanyong Lu and Block T. Study of the early steps of the Hepatitis B Virus life cycle. Int. J. Med. Sci. 2004, 1(1): 21-33.
4. Xuanyong Lu, Paul Weiss and Timothy Block. A phage with high affinity for hepatitis B surface antigen for detection of HBsAg. The Journal of Virological Methods. 119 (1): 51-54, 2004.
5. Xuanyong Lu, Matthew Lee, Trang Tran, and Timothy Block. High level expression of apoptosis inhibitor in hepatoma cell line expressing Hepatitis B virus. Int. J. Med. Sci. 2005, 2(1), 44-51.
6. Tsurng-Juhn Huang, Cheng-Chan Lu, Jui-Chen Tsai, Wei-Jen Yao, Xuanyong Lu, Ming-Derg Lai, Hsiao-Sheng Liu1, Ai-Li Shiau. Novel autoregulatory function of hepatitis B virus M protein on surface gene expression. J Biol Chem. 2005, 280: 27742-27754.
7. Simsek E, Lu X, Ouzounov S, Block TM, Mehta AS. alpha-Glucosidase inhibitors have a prolonged antiviral effect against hepatitis B virus through the sustained inhibition of the large and middle envelope glycoproteins. Antivir Chem Chemother. 2006; 17(5):259-67.
8. Lu X, Lamontagne J, Lu F, Block T. Tumor-associated protein SPIK/TATI suppresses serine protease dependent cell apoptosis. Apoptosis 2008;13:483-94.
9. Jason Lamontagne, Mark Pinkerton, Timothy M. Block and Xuanyong Lu. HCV and HBV replication up-regulate serine protease inhibitor Kazal, resulting in cell resistance to serine protease dependent apoptosis, J. Virol. 2010; 84 907-917.
10. Mark Pinkerton, Felix Lu, Jason Lamontagne, Timothy Block and Xuanyong Lu. Suppression of granzyme A mediated apoptosis may be a reason causing the persistent hepatitis B and hepatitis C virus infection and development of liver cancer. 2010, 19th annual Philadelphia infection and immunity forum, Philadelphia. P65.
11. Guo, H. Pan, X. Mao, R. Zhang, X. Wang, L. Lu, X. Chang, J. Guo, J. T. Passic, S. Krebs, F. C. Wigdahl, B. Warren, T. K. Retterer, C. J. Bavari, S. Xu, X. Cuconati, A. Block, T. M. Alkylated porphyrins have broad antiviral activity against hepadnaviruses, flaviviruses, filoviruses, and arenaviruses. Antimicrob Agents Chemother, 55,478-86, 2011.
12. Felix Lu, Jason Lamontagne, Angela Sun, Mark Pinkerton, Timothy Block and Xuanyong Lu, Role of the inflammatory protein serine protease inhibitor Kazal in preventing cytolytic granule granzyme A mediated apoptosis. Immunology. 2011, accepted.
13. Jason Lamontagne, Courtney Mills, Mark Pinkerton, Richeng Mao, Cally Goddard, Dawei Cai, Haitao Guo,Andy Cuconati, Timothy Block and Xuanyong Lu. Screening and identifying of compounds against hepatitis B virus from safe compound library by high throughput system: real-time immuneprecipitation PCR. In preparation.
14. Michael Kann, Xuanyong Lu, Tanja Tolle and Wolfram Gerlich. Late and early steps in the life cycle of hepatitis b virus. Viral Hepatitis and liver disease- proceeding of the IX. International Symposium Rome 1996. M. Rizzetto editor.
15. Block, T., Xuanyong Lu, A. Mehta, J. park, B. Blumberg, R. Dwek (1997) Role of glycan processing in the trafficking of HBV in liver cells. Proc. Exp. Biol. & Med. (J. Axford, Ed).
16. Xuanyong Lu and Timothy M. Block. Enhancement of infection of HepG2 cells in culture, by pre-digestion of hepadnavirus with V8 protease, Methods in Molecular Medicine. J.Lau ed. The Humana press Inc. CA, USA. 2004, 199-208.
17. Xuanyong Lu . Pathogenesis of Hepatitis B virus- mediated liver injury, North American Journal of Medicine and Science, 2011, 4(1) 1-6.
18. Gerlich WH. Heermann KH. Lu X. Functions of hepatitis B surface proteins. 1992,Archives of Virology - Supplementum. 4:129-32.
19. Block TM. Lu X. Mehta A. Park J. Blumberg BS. Dwek R. Role of glycan processing in hepatitis B virus envelope protein trafficking. Advances in Experimental Medicine &Biology. 435:207-16, 1998.