Dr. Yuhong Du

Emory University School of Medicine, USA

Associate Director

Email: dyuhong@emory.edu

Qualifications

1999-2003 PhD., National University of Singapore, Pharmacy

1993-1996 M.Sc., Shanghai Medical University, Biochemistry

1986-1991 B.Sc., Shanghai Medical University, Pharmacy

Publications (selected)

1. Li Z, Zhao J, Du, Y, Hae Ryoun Park, Shi-Yong Sun, Alastair Aitken, Fadlo R. Khuri, and Haian Fu. (2008) Downregulation of 14-3-3ζ suppresses anchorage-independent growth of cancer cells through anoikis activation. Proc Natl Acad Sci U S A 105(1): 162-167
2. Andrea LK., Du, Y., Shala LThomas, James Snyder, Chun-Yu Wang, Fadlo R. Khuri, Dennis Liotta, and Haian Fu (2008) Inhibition of IKK by a novel curcumin analogue blocks TNFa-induced NFKB activation and promotes JNK signaling. Mol. Pharmacology 74(3): 654-61
3. Du, Y., F. R. Khuri, and H. Fu. (2008) A Homogenous Luminescent Proximity Assay for 14-3-3 Interactions with Both Phosphorylated and Nonphosphorylated Client Peptides. Current Chemical Genomics 2: 40-47
4. Ganesh T, Min J, Thepchatri P, Du Y, Li L, Lewis I, Wilson L, Fu H, Chiosis G, Dingledine R, Liotta D, Snyder JP, Sun A.(2008) Discovery of aminoquinolines as a new class of potent inhibitors of heat shock protein 90 (Hsp90): Synthesis, biology, and molecular modeling. Bioorg Med Chem. 2008 Jul 15;16(14): 6903-10
5. Gunther JR*, Du, Y*, Eric Rhoden, Iestyn Lewis, Brian Revennaugh, Terry W. Moore, Sung Hoon Kim, Raymond Dingledine, Haian Fu, and John A. Katzenellenbogen (2009) A Set of Three Time-Resolved Fluorescence Resonance Energy Transfer Assays for the Discovery of Inhibitors of Estrogen Receptor-Coactivator Binding. J. Biomol. Screen. 14(2):18-193 (*equal contributions)
6. Bialkowska AB, Du, Y, Fu, H, Yang VW (2009) Identification of novel small-molecule compounds that inhibit the proproliferative Kru¨ ppel-like factor 5 in colorectal cancer cells by high-throughput screening. Mol Cancer Ther 8(3): 563–70
7. Du, Y, Li Z, Li L, Zhuo (Georgia) Chen, Shi-Yong Sun, Chen P, Dong M. Shin, Fadlo R. Khuri, and Haian Fu (2009). Distinct growth factor-induced dynamic mass redistribution (DMR) profiles for monitoring oncogenic signaling pathways in various cancer cells. Journal Receptors and Signal Transduction 29(3-4): 182-194
8. Aslan JE, You H, Williamson DM, Endig J, Youker RT, Thomas L, Shu H, Du Y, Milewski RL, Brush MH, Possemato A, Sprott K, Fu H, Greis KD, Runckel DN, Vogel A, Thomas G. (2009) Akt and 14-3-3 control a PACS-2 homeostatic switch that integrates membrane traffic with TRAIL-induced apoptosis. Mol Cell. 34(4): 497-509
9. Jiang J*, Ganesh T*, Du, Y*, Thepchatri P, Rojas A, Lewis I, Kurtkaya S, Li L, Qui M, Serrano G, Shaw R, Sun A, Dingledine R. (2010) Neuroprotection by selective allosteric potentiators of the EP2 prostaglandin receptor. Proc. Natl. Acad. Sci. USA 107(5):2307-12. (*equal contributions)
10. Thepchatri P, Min J, Ganesh T, Du Y, Lewis I, Kurtkaya S, Prussia A, Li L, Sneed B, Plemper RK, Fu H, Liotta DC, Snyder JP, Dingledine R, Sun A. (2009) Cancer and virus leads by HTS, chemical design and SEA data mining. Curr Top Med Chem. 9(13): 1159-71.
11. Hansen KB, Mullasseril P, Dawit S, Kurtkaya NL, Yuan H, Vance KM, Orr AG, Kvist T, Ogden KK, Le P, Vellano KM, Lewis I, Kurtkaya S, Du Y, Qui M, Murphy TJ, Snyder JP, Bräuner-Osborne H, Traynelis SF. (2010) Implementation of a fluorescence-based screening assay identifies histamine H3 receptor antagonists clobenpropit and iodophenpropit as subunitselective N-methyl-D-aspartate receptor antagonists. J Pharmacol Exp Ther. 333(3): 650-62.
12. Thomas SL, Zhao J, Li Z, Lou B, Du Y, Purcell J, Snyder JP, Khuri FR, Liotta D, Fu H. (2010) Activation of the p38- pathway by a novel monoketone curcumin analog, EF24, suggests a potential combination strategy. Biochem Pharmacol. 80(9): 1309-16
13. Qiu X*, Du Y*, Lou B, Zuo Y, Shao W, Huo Y, Huang J, Yu Y, Zhou B, Du J, Fu H, Bu X.(2010) Synthesis and Identification of New 4-Arylidene Curcumin Analogues as Potential Anticancer Agents Targeting Nuclear Factor-κB Signaling Pathway. J Med Chem. 2010 Nov 11. (*equal contributions)
14. Sun, A., Moore, T.W., Gunther, J.R., Kim, M.S., Rhoden, E., Du, Y., Fu, H., Snyder, J.P., and Katzenellenbogen, J.A. (2011) Discovering Small-Molecule Estrogen Receptor alpha/Coactivator Binding Inhibitors: High-Throughput Screening, Ligand Development, and Models for Enhanced Potency. ChemMedChem. 6(4): 654-66
15. Cencic R, Hall D, Robert F, Du Y, Jaeki Min , Lian Li , Min Qui , Iestyn Lewis , Serdar Kurtkaya , Raymond Dingledine , Haian Fu , Dima Kozakov , Sandor Vajda , Jerry Pelletier (2011) Reversing Chemoresistance by Small Molecule Inhibition of the Translation Initiation Complex eIF4F. Proc. Natl. Acad. Sci. USA 108(3): 1046-51
16. Du Y, Zaneta Nikolovska-Coleska, Min Qui, Lian Li, Iestyn Lewis, Dingledine, R; Patricia Gee, Jeanne A. Stuckey, Krzysztof Krajewski, Peter P. Roller, Shaomeng Wang, Fu, H. (2011) A dual readout F2 assay that combines fluorescence resonance energy transfer (FRET) and fluorescence polarization (FP) for monitoring bimolecular interactions. ASSAY and Drug Development Technologies 9 (4): 382-393.
17. Cencic, R., Desforges, M., Hall, D.R.,Kozakov, D., Du, Y., Min, J., Dingledine, R., Fu, H., Vadja, S., Talbot, P.J. and Pelletier, J. (2011). Blocking eIF4E:eIF4G interaction as a strategy to impair coronavirus replication. J. Virol. 85 (13): 6381-6389
18. Li L, Du, Y, Wei Chen, Haian Fu, Harrison DG (2011) A novel high throughput screening assay for discovery of molecules that increase cellular tetrahydrobiopterin. Journal of Biomolecular Screening 16(8): 836-844
19. Zhao J*, Du, Y*, Horton JR*, Upadhyayd AK*, Lou, B, Bai Y, Zhang Y, Du, L, Li, M, Wang B, Zhang, L, Barbieri, JT, Khurih, FR, Cheng, X, and Fu, H. (2011) Discovery and structural characterization of a small molecule 14-3-3 protein–protein interaction inhibitor. Proc. Natl. Acad. Sci. USA 108(39): 16212-6 (*equal contributions)
20. Zhao, J, Meyerkord, CL, Du, Y, Khuri, FR, Fu, H (2011)14-3-3 proteins as potential therapeutic targets. Semin Cell Dev Biol. 2011 Sep; 22(7): 705-12.
21. Jiang J*, Ganesh T*, Du, Y*, Quan Y, Serrano G, Qui M, Speigel I, Rojas A, Lelutiu N, Dingledine R. (2012) Small molecule antagonist reveals seizure-induced mediation of neuronal injury by prostaglandin E2 receptor subtype EP2. Proc. Natl. Acad. Sci. USA. 2012 Feb21; 109(8): 3149-54. (*equal contributions)
22. Smith SM, Min J, Ganesh T, Diebold B, Kawahara T, Zhu Y, McCoy J, Sun A, Snyder JP, Fu H, Du Y, Lewis I, Lambeth JD. (2012) Ebselen and congeners inhibit NADPH oxidase 2-dependent superoxide generation by interrupting the binding of regulatory subunits. Chem Biol. 2012 Jun22; 19 (6): 752-63. 

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