David X. Liu,
Ph.D.
4452 S. Elm, Broken Arrow, OK 74014
Phone: 918-446-6413 (Office); Cell: 509-655-4368;
Email: liud@nsuok.edu
Education
1982 B.S. in
Biochemistry
Fudan University, Shanghai, China
Thesis: Isolation and
characterization of plasmids harbored in thermophilic bacteria.
Advisor: Prof. Shen Ren-quan
1985 M.S. in Molecular Biology
Shanghai Institute of Biochemistry, Chinese Academy of
Sciences
Thesis: Transcription regulation of 5S ribosomal RNA gene
in eukaryotes
Advisor: Prof. Li
Zai-ping
1996 Ph.D. in
Molecular Genetics
City University of New York, New York, NY.
Thesis: Growth-dependent regulation of ribosomal RNA
transcription in Bacillus subtilis
Advisor: Prof. Rivka
Rudner
Positions and Employment History
1986-1987 Research Assistant
The 7th Laboratory
(Gene Regulation), Shanghai Institute of Biochemistry, Chinese Academy of
Sciences, Shanghai, China
1988-1989 Lecturer
Department
of Biology, Qingdao University, Qingdao, Shandong, China
1989-1991 Visiting Research Specialist
Department
of Biological Sciences, University of Illinois at Chicago, IL.
1997-1998 Postdoctoral fellow
New
York University Medical Center, New York, NY.
Project:
Cell cycle deregulation in cancer cells. Advisor: Dr. Michele Pagano.
1998-2002 Postdoctoral
fellow
Columbia
University College of Physicians and Surgeons, New York, NY.
Project: Mechanism of neuronal apoptosis. Advisor: Dr. Lloyd Greene.
2002-2006 Associate Research Scientist
Department
of Pathology
Columbia
University College of Physicians and Surgeons, New York, NY.
2006-2013 Assistant Professor (tenure-track),
Principle Investigator
Department
of Neural and Behavioral Sciences
Pennsylvania
State University College of Medicine, Hershey, PA
2013-2019 Associate
Professor (tenure-track), Principle Investigator
Department
of Pharmaceutical Sciences
Washington
State University College of Pharmacy, Spokane, WA
2019-present Associate Professor (tenure-track), Principle
Investigator
Department
of Natural Sciences
Northeastern
State University Gregg Wadley College of Science & Health Professions
Honors and Awards
2017-2018 National EMPEROR Science Award Mentor
2015 F1000Prime
Recommendation of our paper Madarampalli
et al., Cell 162(3):580-592. https://f1000.com/prime/725675029
2011 Breast
Cancer Research Era of Hope Scholar, U.S. Department of Defense
2008 Beckman
Young Investigator Nominee, Penn State University
1998-2001 Research
Fellow, Blanchette Rockefeller Foundation.
NIH Study Sections and Other Grant Review and Committee Panels
2016/11 Member, NIH Special Emphasis Panel (SEP) for Oncology 1-Basic
Translational IRG R15 AREA grant ZRG1 OBT-J (80)
2017/04 Member, The Research Foundation of the City University of
New York (RFCUNY) Peer Review Program on an NIH SCORE study
2017/05 Member, NIH Special Emphasis Panel (SEP) for Neural
Regulation of Cancer R01/R21 grant ZRG1 OBT-J (55) R
2017/05 Member, NIH Special Emphasis Panel (SEP) for Neural
Regulation of Cancer R01/R21 grant ZRG1 OBT-H (07) S
2017/09 Member of Program Committee, 5th Annual
International Conference on Pharmacology and Pharmaceutical Sciences (PHARMA
2017; http://pharma-conf.org/Committee.html).
Editorial Boards and Professional Society
2002-2010 Member, Society for Neuroscience
2008-present Member, American Association for Cancer
Research
2011-present Member, American Society for Biochemistry and
Molecular Biology
2012-present Advances
in Biological Chemistry (Editorial Board)
2012-present Cell
and Developmental Biology (Editorial
Board)
2013-present American
Journal of Cancer Biology (Senior Editor)
2014-present American
Journal of Pharmacology and Toxicology (Regional Editor)
2014-present International
Journal of Cancer and Oncology (Editorial Board)
2014-present Journal
of Cytology & Molecular Biology (Editorial Board)
2014-present Journal of Pharmaceutical Science
& Drug Designing
2015-present Journal of
Neurooncology
2016-present Neuro-Oncology:
Open Access
Ad Hoc Journal Reviewers
Biochem Biophys Res. Comm.; Biochimica et Biophysica Acta; BMC Cancer; Brain
Res. Bulletin;
Cancer Biology & Therapy; Cancer Research; Cell and Developmental
Biology;
Current Pharmaceutical Design; J. Biochemistry; J. Biological Chemistry;
J. Neurochemistry;
J. Neuroscience; J. Qingdao Univ; Life Sciences; Molecular and Cellular
Biology;
Molecular Cancer Research; Oncogene;
PNAS (Proceedings of the National Academy
of Sciences USA)
Institutional
Committees
2016-2018 PharmD Honors Program Committee, WSU
College of Pharmacy
2016 Faculty Awards Workgroup, WSU College
of Pharmacy
2015-2018 Student
Progress Committee, WSU College of Pharmacy
2014-2015 Ph.D. Admissions Committee, WSU College of
Pharmacy
2012 Biomedical Sciences Graduate Core
Curriculum Task Force, PSU COM
2010-2013 Molecular
Medicine Graduate Recruitment Committee, PSU College of Medicine
2010-2013 Biomedical
Sciences Graduate Program Advertising Committee, PSU COM
2008-2013 Committee
for Biomedical Sciences and Engineering Seminar Series, PSU COM
2008 Department
of Neural and Behavioral Sciences Faculty Recruitment Committee, PSU COM
2007-2010 Cell and Molecular Biology Graduate
Advisory Committee, PSU COM
2007-2010 Cell and Molecular Biology Graduate Recruitment
Committee, PSU COM
2006-2013 Graduate
Faculty of the following PSU Graduate Programs
Anatomy
Program, Cell and Developmental Biology Program, Cell and Molecular Biology
Program, Biomedical Sciences Program, Genetics Program, M.D/Ph.D Program,
Molecular Medicine Program and Neuroscience Program
Teaching (underlined are those served as Course Director/Co-Director)
2020(expected) Biol 4412 Research in Biology, NSU
College of Pharmacy Science
& Health Professions
2020(expected) Biol 4002 Experimental Design, NSU
College of Pharmacy Science
& Health Professions
2019-2020 Biol 3124 Cell Biology, NSU College
of Pharmacy Science
& Health Professions
2019-2020 Biol 4232 Molecular & Cellular Bio
Lab, NSU College of Pharmacy Science & Health Professions
2019 Biol 4242 Trends & Issues in
Molec. Bio, NSU College of Pharmacy Science & Health Professions
2019-present Biol 4411 Research in Biology, NSU
College of Pharmacy Science
& Health Professions
2018 PharmSci 576 Biophysical Methods,
WSU College of Pharmacy
2017 PharmSci 576 Biophysical Methods,
WSU College of Pharmacy
2016 PharmSci 572 Current Topics
(Fundamentals) of Cancer Biology, WSU College of Pharmacy
2016 PharmSci 576 Biophysical Methods,
WSU College of Pharmacy
2014-2019 PharmSci 597 Graduate Seminar, WSU
College of Pharmacy
2014 PharmSci542 Integrated
Pharmacology IV, WSU College of Pharmacy
2008-2013 Biomedical
Sciences 597A, PSU College of Medicine
2011-2013 Neuro
520, PSU College of Medicine
2009 Cell
and Developmental Biology IBIOS 592, PSU University Park
2008-2013 Cell
and Molecular Biology 597, PSU College of Medicine
2008-2009 Genetics
590, PSU College of Medicine
2008 Genetics
597, PSU College of Medicine
2009-2010 Cell
and Molecular Biology 506, PSU College of Medicine
2007 Cell
and Molecular Biology 591, PSU College of Medicine
1992-1996 Principle
Biology, City Univ. of NY
1993-1995 Molecular
Genetics, City Univ. of NY
1988-1988 Cell
and Molecular Biology, Qingdao University
1988-1989 Biochemistry,
Qingdao University
Current and Former
Trainees (underlined co-authored at least one peer-reviewed
manuscript with me)
Postdoctoral Scholars and Research
Faculty/Visiting Professor:
2006-2009 Guangfu
Li (Current position: Assistant Professor, University of Virginia)
Co-authored: Cell 162(3):580-592, 2015; J.
Biol. Chem. 286(23):20251-9, 2011, J. Biol. Chem. 286(9):7705-13, 2011;
and Molecular
Cancer Research 7(6):933-43, 2009.
2012-2014 Yunsheng Yuan (Current position: Assistant Professor, Department of Agricultural Sciences,
Shanghai Jiaotong University, Shanghai, China)
Co-authored: Cell 162(3):580-592,
2015 and J. Biol. Chem.
293(8):2939-2948, 2018.
2014-2016 Eugene
Kim (Current position: Adjunct Assistant Professor, Department of Medical
Sciences, WSU)
Co-authored: Cell Cycle 14(20):3215-6, 2015.
2014-2015 Guihai Zhang
(Current position: Director and Associate Professor, Zunyi Medical College,
Guizhou, China)
2015-2016 Xiuping Zhang (Current position:
Associate Professor, College of Animal Science, Tarim University, Alar,
Xinjiang, China)
2011-2012 Suresh
Anaganti (Current position: Senior Scientist, Keystone Biotech, Inc, PA)
2012-2013 Min He (Current
position: Professor and Deputy Director, Cancer Research Institute, University
of Guangxi, China)
2014-2015 Bhanupriya
Madarampalli (Current position: Postdoctoral scholar, Univ. of Washington,
Seattle, WA)
Co-authored: Cell
162(3):580-592, 2015.
Graduate Students, Rotation
Students, Undergraduate Students and Interns:
2020(expected) Lindsey Howe, undergraduate student at NSU
2020(expected) Tyler Gore, undergraduate student at NSU
2020(expected) Ashley Kennedy, undergraduate student at NSU
2019-present Leon
Elias, undergraduate student at NSU
2019-present Ciboney
Ware, undergraduate student at NSU
2017-2019 Phillip
Yan (B.Sc. 2016, Cornell University graduate)
2017-2019 Jordan
Nicols (B.Sc. 2017, University of Washington graduate)
2016-2018 Victoria
Chong (PharmD Honors Program student, Washington State University)
2016-2017 Henning
Knipprath (Whitworth University student intern)
Co-authored: J. Biol. Chem. 293(8):2939-2948, 2018.
2016 Luke
Verst (Whitworth University student intern)
2016 Sarkar, Soumyadeep (Ph.D.
candidate, Washington State University)
2015-2018 Edward
Liu (Mead High School summer student intern)
2015-2017 Roberto
Murillo (Whitworth University student intern)
2015-2016 Thaok
Nguyen (PharmD Honors Program student, Washington State University)
2015-2016 Zahrah
Ali (PharmD Honors Program student, Washington State University)
2015 Yadira Paramo (Ph.D. candidate, Washington
State University)
2015 Alex Stoudt (Undergraduate student,
Washington State University-Pullman)
2014-2019 Karri
Gaither (Ph.D. candidate, Department of Pharm Sci., WSU)
Co-authored: J. Biol. Chem. 293(8):2939-2948, 2018.
2014 Josiah Hopkins (Mead High School
graduate, pre-undergraduate to University of Washington)
2014-2015 Dunxin
Shen (Ph.D. candidate, Washington State University)
2012-2014 Kathleen
Lengel (Current position: Ph.D. candidate, Penn State University).
Co-authored: Cell 162(3):580-592, 2015; Cell Cycle 14(20):3215-6, 2015 and Cell
and Development Biol. 1:e114. doi:10.4172/2168-9296.1000e114, 2012.
2011 Sadie
Hogan (Current position: Ph.D. candidate, Penn State University)
2011 Jeffery
Nguyen (Current position: M.D./Ph.D. candidate, Penn State University)
2010 Dongyin
Guan, M.S. (Current position: Ph.D. candidate, Case Western Reserve
University)
Co-authored: J. Biol. Chem. 286(23):20251-9,
2011.
2010-2011 Ming
Gao, M.S.
2010-2011 Zhengshan
Liu, M.S.
Co-authored: J.
Biol. Chem. 286(23):20251-9, 2011.
2010-2012 Dan
Liu, M.S. (Current position: Research Assistant, University of Maryland)
Co-authored: JBC 286(23):20251-9, 2011; JBC
287(23):19599-609, 2012; Cell 162(3):580-592, 2015.
2010 Matthew
Moureau (Current position: Ph.D. candidate, Penn State University)
Co-authored: J. Biol. Chem. 286(9):7705-13,
2011.
2009-2011 Xijun
Liu, M.S. (Current position: Ph.D. candidate, University of Zhejiang
Sci-Tech, China)
Co-authored: J.
Biol. Chem. 287(23):19599-609, 2012; BMC Cancer 10:684-694, 2010.
2009 Jeremy
Haakenson (Current position: Ph.D. candidate, Penn State University)
Co-authored: Targeting New Pathways and Cell Death in
Breast Cancer. Ed. Rebecca L.
Aft. InTech, ISBN 978-953-51-0145-1, pp. 71-83.
2008 Douglas
Dluzen (Current position: Ph.D. candidate, Penn State University)
Co-authored: J. Biol. Chem. 286(9):7705-13,
2011.
2008 Diana
Tacelosky (Current position: M.D/Ph.D. candidate, Penn State University)
Co-authored: J. Biol. Chem. 286(9):7705-13,
2011.
2007 Abbas
Alibhoy (Current position: Ph.D. candidate, Penn State University)
Technician:
2010-present Michelle
(Yidi) Xu, M.S.
Co-authored: JBC 286(23):20251-9, 2011; Cell 162(3):580-592,
2015 and JBC
293(8):2939-2948, 2018.
Graduate Student Thesis
Committees:
2017-2019 Mahamudul
Haque (Ph.D. candidate, Department of
Pharm Sci., WSU)
2015-2019 Solomon
Agere (Ph.D. candidate, Department of Pharm Sci., WSU)
2015-2019 Ana
Vergara (Ph.D. candidate, Department of Pharm Sci., WSU)
2015-2019 Aimee
Bell (Ph.D. candidate, Department of Pharm Sci., WSU)
2014-2019 Karri
Gaither (Ph.D. candidate, Washington State University)
2014-2015 Mandi
Hopkins (Ph.D candidate, Department of Pharm Sci., WSU)
2013-2015 Dustin
Rae (Ph.D candidate, Department of Pharm Sci., WSU)
2010-2013 Kari
Duck (PhD candidate, CDB Program, PSU,).
2007-2010 Jenn
Wentzel (Anatomy MS Program, PSU).
2006-2007 Soniya Sinha
(Genetics MS Program, PSU).
Research Funding
Current:
R15CA205375 (PI: Liu, DX) 01/01/17-12/31/19
(extended due to institution change)
NIH NCI $456,000
Mechanism of ATF5 addition
in breast cancer (active)
Pending:
RO1 (PI: Liu, DX) 07/01/19-06/30/24
NIH NCI $1,912,500
Role of ATF5 in breast
cancer
Recommended for Funding as an Alternate:
CA093484
(PI: Liu, DX) 07/01/10-06/31/13
U.S. Department of Defense $1,576,415
Regulation
of WNT/beta-Catenin Signaling by ATF5 in Melanoma
Completed:
Start-Up Founding
Grant (PI: Liu, DX) 07/01/13-06/30/16
Washington State U. College of Pharmacy $550,000
Role of
ATF5 in breast cancer
RSG-08-288-01-GMC
(PI: Liu, DX) 09/01/08-12/31/13
American Cancer Society $720,000
Mechanism
of ATF5 pro-survival function in cancer cells
BC085617
(PI: Liu, DX) 08/01/09-07/31/14
U.S. Department of Defense $116,324
Identification
of ATF5-interacting SH3-containing proteins in breast cancer cells
Dean’s
Feasibility Grant (PI: Liu, DX) 07/01/08-06/30/09
Penn State College of Medicine $25,000
Identification
of regulated neuronal death-genes
Start-Up Founding
Grant (PI: Liu, DX) 07/01/06-06/30/09
Penn State College of Medicine $300,000
Function
of ATF5 in glioma
Peer-Reviewed Publications
2018
1. Xia P, Liu Y, Chen J,
Coates S, Liu DX, Cheng Z. (2018). Inhibition
of cyclin-dependent kinase 2 protects against doxorubicin-induced cardiomyocyte
apoptosis and cardiomyopathy. J.
Biol. Chem. 293(51):19672-19685.
2. Yuan Y, Gaither K, Kim
E, Liu E, Hu M, Lengel K, Qian D, Xu Y, Wang B, Knipprath H, Liu DX*. (2018). SUMO2/3 modification of activating
transcription factor 5 (ATF5) controls its dynamic translocation at the
centrosome. J. Biol. Chem. 293(8):2939-2948.
2017
3. Wang M, Hu M, Li Z, Qian
D, Wang B, Liu DX*. (2017). miR-141-3p functions as a tumor
suppressor modulating activating transcription factor 5 in glioma. Biochem Biophys Res Commun. 490(4):1260-1267.
4. Hu M, Wang B Qian D,
Huang R, Wang M, Li L, Zhang L, and Liu
DX*. (2017) Human cytomegalovirus immediate-early protein promotes survival
of glioma cells through interacting and acetylating ATF5. Oncotarget 8:32157-32170.
5. Qian X, Li X, Cai Q, Zhang C, Jiang Y, Lee J, Hawke D, Wang Y, Xia Y,
Zheng Y, Jiang B, Liu DX, Jiang T,
Lu Z (2017). Phosphoglycerate kinase 1 phosphorylates Beclin1 to induce
autophagy. Molecular Cell 65(5):917-931.
2016
6. Cheng Y, Ren X, Yuan Y,
Shan Y, Zhang L, Takahashi Y, Yang JW, Li Y, Li L, Chen X, Liu DX, Ryazanov A, and Yang LM (2016). eEF-2 Kinase is a Critical Regulator of
Warburg Effect through Controlling Translational Elongation of PP2A-A. Oncogene 35(49):6293-6308.
2015
7. Lengel K, Kim E, and Liu DX* (2015). ATF5 regulates
the cell cycle-dependent centrosome cycle. Cell Cycle 293(8):2939-2948.
8. Madarampalli B, Yuan Y, Liu D, Lengel K, Xu
Y, Li, G., Yang J, Liu X, Lu Z and Liu
DX* (2015). ATF5 Connects the
Pericentriolar Materials to the Proximal End of the Mother Centriole. Cell 162(3):580-592.
F1000Prime
Recommended Aug. 15, 2018. https://f1000.com/prime/725675029
2014
9. Jiang Y, Wang Y, Wang T, Hawke DH, Zheng Y, Li X, Zhou Q, Majumder S, Bi E, Liu DX, Huang S, and Lu Z (2014).
PKM2 phosphorylates MLC2 and regulates cytokinesis of tumour
cells. Nature Communications 5,
5566. doi:10.1038/ ncomms6566.
2013
10. Cheng Y,
Ren X, Gowda ASP, Shan Y, Zhang L, Yuan Y-S, Patel R, Wu H, Huber-Keener K,
Yang JW, Liu DX, Spratt TE and Yang
J-M (2013). Interaction of Sirt3 with
OGG1 contributes to repair of mitochondrial DNA and protects from apoptotic
cell death under oxidative stress. Cell
Death and Disease 4, e731. doi:10.1038/cddis.2013.254
2012
11. Hu M, Wang
B*, Qian D, Li L, Zhang L, Song X, and Liu
DX* (2012). Interference with ATF5
function enhances the sensitivity of human pancreatic cancer cells to
paclitaxel-induced apoptosis. Anticancer
Res. 32(10):4385-94.
12. Lengel KL
and Liu DX* (2012). Cell type-dependent function of ATF5: Where we go from here. Cell and Development Biol. 1:e114. doi:10.4172/2168-9296.1000e114.
13. Zhang Y,
Cheng Y, Ren X, Horis T, Huber-Keener KJ, Zhang L, Yap KL, Liu DX, Shantz L, Qin Z, Zhang S, Wang J, Wang HG, Shih IM, and
Yang JM (2012). Dysfunction of Nucleus
Accumbens-1 Activates Cellular Senescence and Inhibits Tumor Cell Proliferation
and Oncogenesis. Cancer Res. 72(16):4262-75. PMID: 22665267.
14. Chen A,
Qian D, Wang B, Hu M, Lu J, Qi Y, and Liu
DX (2012). ATF5 is overexpressed in
epithelial ovarian carcinomas and interference with its function increases
apoptosis through the downregulation of Bcl-2 in SKOV-3 cells. Intl. J. Gynecological Path. 31(6):532-7. PMID: 23018213.
15. Liu X, Liu
D, Qian D, Dai J, Jiang S, Stanley B, An Y, Yang J, Wang B, Liu X and Liu DX* (2012). Nucleophosmin
(NPM1/B23) interacts with ATF5 and promotes proteasome- and caspase-dependent
ATF5 degradation in hepatocellular carcinoma cells. J. Biol. Chem. 287(23):19599-609. PMID: 22528486.
2011
16. Liu DX*, Qian D, Wang B,
Yang JM, and Lu Z (2011). p300-dependent ATF5 acetylation is essential for
Egr-1 gene activation and cell proliferation and survival. Mol. Cell. Biol., 31(18):3906-3916. PMID: 21791614.
17. Dluzen D,
Li G, Tacelosky D, Moreau M, and Liu DX* (2011). Bcl-2 is a downstream target of ATF5 that mediates the pro-survival
function in a cell type-dependent manner. J. Biol. Chem. 286(9):7705-13. PMID: 21212266.
18. Zhang Y,
Cheng Y, Ren X, Zhang L, Yap KL, Wu H, Patel R, Liu DX, Qin ZH, Shih IM and Yang JM (2011). NAC1 modulates sensitivity of ovarian cancer
cells to cisplatin via altering the HMGB1-mediated autophagic response. Oncogene 31(8):1055-64. PMID: 21743489.
19. Li G, Xu
Y, Guan D, Liu, Z and Liu DX* (2011). HSP70 promotes survival of C6 and U87 glioma cells by inhibition of
ATF5 degradation. J. Biol. Chem. 286(23):20251-9. PMID: 21521685.
20. Zheng Y,
Yang W, Xia Y, Hawke D, Liu DX and
Lu, Z (2011). Ras-induced and ERK1/2 phosphorylation-dependent isomerization of
PTP-PEST by PIN1 promotes FAK dephosphorylation by PTP-PEST. Mol. Cell. Biol., 31(21):4258-4269. PMID: 21876001.
2010
21. Liu X,
Yang JM, Zhang SS, Liu XY, and Liu DX* (2010). Induction of cell cycle arrest at G1 and S phases and cAMP-dependent differentiation
in C6 glioma by low concentration of cycloheximide. BMC Cancer 10:684-694.
22. Samarrai
W, Liu DX, White AM, Studamire B,
Edelstein J, Srivastava A, Widom RL, and Rudner R (2010). Differential response
of Bacillus subtilis ribosomal 1 RNA promoters to nutritional stress. J. Bact. 193(3): 723-33.
23. Hu M, Qian D, Hou Y, Peng K, Li L, Song X, Liu
DX, and Wang B (2010). Expression of ATF5 and Bax in
the apoptosis of pancreatic cancer cells SW1990 induced by paclitaxel. J.
Med. Postgrad. (China), 23(11):1127-31.
2009 and before
24. Wu H, Zhu
H, Liu DX, Niu TG, Ren X, Patel R,
Hait, WN, and Yang JM (2009). Silencing
of elongation factor-2 kinase potentiates the effect of 2-deoxy-D-glucose
against human glioma cells through blunting of autophagy. Cancer Research 69(6):2453-60.
25. Li G, Li
W, Angelastro JM, Greene LA, and Liu DX* (2009). Identification of a novel DNA
binding site and a transcription target for ATF5 in C6 glioma and MCF-7 breast
cancer cells. Molecular Cancer Research 7(6):933-43.
26. Greene LA, Liu DX, Troy CM, and Biswas SC
(2007). Cell Cycle Molecules Define A Pathway Required For Neuron Death In
Development And Disease. Biochimica
et Biophysica Acta 1772:392-401.
27. Biswas SC, Liu DX, and Greene LA (2005). Bim is a direct target of a neuronal
E2F-dependent apoptotic Pathway. J.
Neurosci., 25(37):8349-58.
28. Liu DX*, Nath N, Chellappan
SP, and Greene LA (2005). Regulation of
neuronal survival and death by p130 and associated chromatin modifiers. Genes&Dev. 19(6):719-32.
29. Greene LA,
Biswas SC, and Liu DX (2004). Cell cycle molecules and vertebrate neuron
death: E2F at the hub. Cell
Death Differ. 11(1):49-60.
30. Liu DX*, Biswas SC, and
Greene LA (2004). B-myb and C-myb play
required roles in neuronal apoptosis evoked by NGF deprivation and DNA damage. J.
Neurosci. 24(40):8720-5.
31. Angelastro
JM, Moon NY, Liu DX, Yang AS, Greene
LA, Franke TF (2001). Characterization of a novel isoform of caspase-9 that
inhibits apoptosis. J. Biol. Chem. 276(15):12190-200.
32. Liu DX* and Greene LA
(2001). Neuronal apoptosis at the G1/S
cell cycle checkpoint. Cell
Tissue Res. 305(2):217-28.
33. Liu DX* and Greene LA
(2001). Regulation of neuronal survival
and death by E2F-dependent gene repression and derepression. Neuron 32(3):425-38.
34. Zhang Y, Wang Z, Liu DX, Pagano M, Ravid K (1998). Ubiquitin-dependent
degradation of cyclin B is accelerated in polyploid megakaryocytes. J.
Biol. Chem. 273(3):1387-92.
35. Lu Z, Liu DX, Hornia A, Devonish W, Pagano M,
Foster DA (1998). Activation of Protein Kinase C Triggers Its Ubiquitination
and Degradation. Mol. Cell. Biol. 18(2):839-45.
36. Liu DX* (1990). DNA regions in the genome of silkworm Attacus ricini contains sequences that
structurally and functionally resembles both eukaryotic and prokaryotic
promoters. J. Qingdao Univ. 2(1):88-94.
37. Liu DX* and He X
(1989). A study on plasmids harbored in
thermophilic bacteria – Isolation and characterization of plasmids from Bacillus thermophilus. Chinese
J. Biochemistry 5(1):56-60.
38. Liu DX*, Shen L and Li Z (1989). Attacus ricini genomic DNA contains
regions that can act as prokaryotic promoters. J. Genetics (Allerton Press, New York, NY.) 15(1):59-72.
39. Liu DX, Shen L and Li Z (1988). Cloning and characterization of DNA fragments from the genome of
silkworm A. ricini that function as
promoters in E. coli. Acta
Genetica Sinica 15(2):102-10.
Book Chapters (*as Corresponding author)
1. Ding Y and Liu DX* (2007). Cycling to
Death: Involvement of Cell Cycle Molecules in Neuronal Apoptosis. In: Cell Apoptosis Research Advances. Ed. Carter. R. Kattleworth. Nova
Scientific, New York, NY. pp 23-41.
2. Haakensen J, Kester M and Liu DX* (2011). The ATF/CREB family of
transcription factors in breast cancer. In: Targeting New Pathways and Cell
Death in Breast Cancer. Ed.
Rebecca L. Aft. InTech, ISBN 978-953-51-0145-1, pp. 71-83.
Patent Application
1. Liu, David
X and Li Guangfu, U.S. Patent Application No. 61/149,141:
Compositions
and Processes Relating to Transcription Factor ATF5
Invited Talks and Presentations (recent)
Southern
Research Institute, Birmingham, AL, 2018
Zhejiang
Sci-Tech University, Hangzhou, China, 2018
MD
Anderson Cancer Center, University of Texas, Houston, TX, 2018
Northeastern
State University, Broken Arrow, OK, 2018
Hunter
College, City University of New York, New York, NY, 2017
AACR Annual Meeting, Washington
DC, 2017
Haixin
Group Co., Ltd., Shanghai, China. 2016
Qingdao University
Medical College, Qingdao, China. 2015
Institute of Genetics
and Developmental Biology, Chinese Academy of Sciences, Beijing, China. 2015
Washington State
University, Cancer and Aging Research Group, Spokane, WA 2014
AACR Annual Meeting,
San Diego, CA 2014
Washington State
University College of Pharmacy, Spokane, WA 2014
Pennsylvania State
University, Hershey, PA 2013
Washington State
University, Pullman, WA 2013
North Dakota State University,
Fargo, ND 2013
Oakland University,
Rochester, MI 2013
Texas Tech University
Health Sciences Center School of Medicine, Lubbock, TX, 2013
Qingdao
University Medical College, Qingdao, China, 2013
Department of
Biochemistry and Microbiology, Marshall University, Huntington, VW, 2012
Department of
Neuro-Oncology, MD Anderson Cancer Center, Houston, TX, 2012
Hunter College, City
University of New York, New York, NY, 2011
Translational
Research in Mitochondria, Aging, and Disease – TrMAD Symposia, Pittsburgh, PA,
2011
Department
of Biochemistry and Molecular Biology, Penn State University, Hershey, PA, 2011
U.S. Department of
Defense Breast Cancer Era of Hope Scholars, Orlando, Florida, 2011
Penn State Cancer
Institute, Penn State University, Hershey, PA, 2011
Focus of Research
My
laboratory studies the molecular and cellular mechanisms that control cell
proliferation and survival. Our goal is to identify molecules and signaling
pathways that are deregulated in major human diseases as in cancer and to use
this knowledge for therapeutic intervention. Recent work from my laboratory and
several other laboratories have shown that the activating transcription factor
5 (ATF5) is required for cell survival in cancer cells but is dispensable in
non-cancer cells. We also found that ATF5 deficiency significantly reduced
tumor burden in PyMT mice. Mechanistically, we demonstrated that ATF5 activates
the transcription of Bcl-2 and Egr-1, promoting cell survival and
proliferation, and acts as an essential structural component in the centrosome,
regulating genomic stability in a cell-cycle-dependent manner. Our studies
further indicated that ATF5 is enriched at the midbody and controls
cytokinesis. In addition, ATF5 is interdependently activated with NFkB and
c-Src in transformed cells, which in turn activates the PI3K/mTOR signaling
pathway. Moreover, our data indicated that ATF5 plays an essential role in the
transformation-dependent activation of 5’-terminal polypyrimidine track (5’-TOP)
genes, whose expression is tightly associated with cell proliferation and
survival and is exclusively regulated at translational level. Our work has been
published in peer-reviewed journals including Cell, Neuron, Genes&Dev.,
Molecular Cell, Nature Communications, Oncogene, Cancer Research, among others,
and is currently supported by a grant from NCI.