Dr. Shirley Shidu Yan

University of Kansas, USA

Email: shidu@ku.edu

Qualifications

1989  Ph.D., Physicians & Surgeons College, Columbia University, USA.

1986  M.S., Fujian Medical University, China.

1983  M.D. Fujian Medical University, China.

Publications

1. Yan SS, Chen D, Yan S, Guo L, Du H, Chen JX. RAGE is a key cellular target for Abeta-induced perturbation in Alzheimer’s disease. Front Biosci (Schol Ed) 2012 Jan 1;4:240-50. PMID: 22202057
2. Du H, Guo L, and Yan SS. Synaptic mitochondrial pathology in Alzheimer’s Disease. Antioxid Redox Signal. 2012, June 15;16(12):147-75. PMID: 21942330
3. Fang F, Chen X, Huang T, Luddy JS, Yan SS. Multi-faced neuroprotective effects of Ginsenoside Rg1 in an Alzheimer mouse model. Biochim Biophys Acta. 2012 Feb;1822(2):286-92. Epub 2011 Oct 12.
4. Yao J, Du H, Fang F, Wang C, Lue F, Guo L, Chen D, Stern DM, Gunn Moore FJ, Xi Chen J, Arancio O, Yan SS. Inhibition of amyloid (Abeta) peptide-binding alcohol dehydrogenase-Abeta interaction reduces Abeta accumulation and improves mitochondrial function in a mouse model of Alzheimer’s disease. J Neurosci. 2011 Feb 9;31(6):2313-20. PMID: 21307267
5. Alikhani N, Guo L, Yan S , Du H,  Pinho CM, Chen JX, Glaser E and Yan SS. Decreased proteolytic activity of the mitochondrial Aβ degrading enzyme, PreP peptidasome, in Alzheimer’s Disease brain mitochondria. Journal of Alzheimer’s disease 2011, 27:75-58
6. Du H, Guo L, Yan S, Sosunov AA, Mckhann GM, Yan SS. Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model. Proc Natl Acad Sci U S A. 2010, Oct 26;107(43):18670-5. Epub 2010 Oct.
7. Origlia N, Bonadonna C, Rosellini A, Leznik E, Arancio O, Yan SS, Domenici L. Microglial RAGE-dependent signal pathway drives Aβ-induced synaptic depression and long-term depression impairment in entorhinal cortex. The Journal of Neuroscience, August 25, 2010, 30(4): 11414-11425.
8. Xu HW, Wu ZY, Fang F, Guo L, Chen D, Chen JX, Stern D, Taylor G, Chess L, Jiang H, Yan SS. Blockade of LRG-47 (Irgm1) promotes apoptosis and suppresses induction of experimental autoimmune encephalomyelitis. FASEB J. 2010 May;24(5):1583-92. Epub 2010 Jan 7.
9. Du H, Yan SS: Mitochondrial permeability transition pore in Alzheimer's disease: Cyclophilin D and amyloid beta. Biochim Biophys Acta. 2010 Jan;1802(1):198-204. Epub 2009 Jul 16.
10. Du H, Yan SS: Mitochondrial medicine for neurodegenerative diseases. Int J Biochem Cell Biol. 2010 Jan 12. [Epub ahead of print]
11. Origlia N, Capsoni S, Cattaneo A, Fang F, Arancio O, Yan SD, Domenici L.  Abeta-dependent inhibition of LTP in different intra-cortical circuits of the visual cortex: the role of RAGE. J Alzheimers Dis. 2009, May; 17(1):59-68.
12. Du H, Guo L, Zhang W, Rydzewska M, Yan S: Cyclophilin D deficiency improves mitochondrial function and learning/memory in aging Alzheimer disease mouse model, Neurobiol Aging 2011 Mar;32(3):398-406.  Epub 2009 Apr 11.
13. Takuma K, Fang F, Zhang W, Yan S, Fukuzaki E, Du H, Sosunov A, McKhann G, Funatsu Y, Nakamichi N, Nagai T, Mizoguchi H, Ibi D, Hori O, Ogawa S, Stern D,  Yamada K, and  Yan SS. RAGE-mediated signaling contributes to intraneuronal transport of amyloid-b and neuronal dysfunction. Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):20021-6. Epub 2009 Nov 9. Faculty 1000 Medicine.
14. Fang F , Lue LF, Walker DG , Xu HW, Luddy J, Chen D, Schmidt A, Stern DM, Arancio O, Chen JX, Yan SS. RAGE-dependent signaling in microglia contributes to neuroinflammation, Aß accumulation, and impaired learning/memory in a mouse model of Alzheimer’s disease. FASEB J. 2010 Apr;24(4):1043-55. Epub 2009 Nov 11.
15. Du H, Guo L, Fang F, Chen D, Sosunov AA< Mckhann GM, Yan Y, Wang C, Zhang H, Molkentine JD, Gunn-Moore FJ, Vonsattel JP, Arancio O, Chen JX, Yan SD. Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease. Nat Med. 2008 Oct;14(10):1097-105. Epub 2008 Sep 21. PMID: 18806802, Faculty 1000 of Biology,
16. Origlia N, Righi M, Capsoni S, Cattaneo A, Fang F, Stern DM,  Chen JX,  Schmidt AM, Arancio O, Yan SD, Domenici L. (co-corresponding author) Receptor for Advanced Glycation Endproducts (RAGE)-dependent activation of p38 Mitogen-Activated Protein Kinase contributes to amyloid β-mediated cortical synaptic dysfunction. J. Neurosci. 2008 Mar 26;28:3521-3530.
17. Caspersen C, Wang N, Yao J, Sosunov A, Chen X, Lustbader JW, Xu HW, Stern D, McKhann G, Yan SD. Mitochondrial Abeta: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease. FASEB J. 2005 Dec;19(14):2040-1. Epub 2005 Oct 6.
18. Takuma K, Yao J, Huang J, Xu H, Chen X, Luddy J, Trillat AC, Stern DM, Arancio O, Yan SS. ABAD enhances Abeta-induced cell stress via mitochondrial dysfunction. FASEB J. 2005 Apr;19(6):597-8. Epub 2005 Jan 21.
19. Arancio O, Zhang HP, Chen X, Lin C, Trinchese F, Puzzo D, Liu S, Hegde A, Yan SF, Stern A, Luddy JS, Lue LF, Walker DG, Roher A, Buttini M, Mucke L, Li W, Schmidt AM, Kindy M, Hyslop PA, Stern DM,Yan SS. RAGE potentiates Abeta-induced perturbation of neuronal function in transgenic mice.  EMBO J. 2004 Sep 30:1-10. Faculty of 1000 Top 10 Neuroscience.
20. Lustbader JW, Cirilli M, Lin C, Xu HW, Takuma K, Wang, N, Caspersen C, Chen X, Pollak S, Chaney M, Trinchese F, Liu S, Gunn-Moore F, Lue LF, Walker DG, Kuppusamy P, Zewier ZL, Arancio O, Stern D, Yan SD, Wu H. (2004) ABAD Directly Links Aß to Mitochondrial Toxicity in Alzheimer's Disease.  Science  2004 304: 448-452. Faculty of 1000 Top 10 Neuroscience
21. Yan SS, Wu ZY, Zhang HP, Furtado G, Chen X, Yan SF, Schmidt AM, Brown C, Stern A, LaFaille J, Chess L, Stern DM, Jiang H. Suppression of experimental autoimmune encephalomyelitis by selective blockade of encephalitogenic T-cell infiltration of the central nervous system. Nature Medicine. 2003 Mar; 9(3): 287- 93. Epub 2003 Feb 24
22. Yan SD, Zhu H, Zhu A, Golabek A, Du H, Roher A, Yu J, Soto C, Schmidt A, Stern D, and Kindy M. Receptor-dependent cell stress and amyloid accumulation in systemic amyloidosis. Nature Medicine 6(6): 643-651, 2000
23. Yan SD, Fu J, Soto C, Chen X, Zhu H, Al-Mohanna F, Collison K, Zhu A, Stern E, Saido T, Tohyama M, Ogawa S, Roher A and Stern D. An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer’s disease. Nature 389(6652):689-695 1997.
24. Yan SD, Zhu H, Fu J, Yan S-F, Roher A, Tourtellotte W, Rajavashisth T, Chen X, Godman CG, Stern D and Schmidt AM: Amyloid-ß peptide-receptor for advanced glycation endproduct interaction elicits  neuronal expression of macrophage-colony stimulating factor: a proinflammatory pathway in Alzheimer disease. Proc. Natl. Acad. Sci. U. S. A 94:5296-5301,1997
25. Yan SD, Chen X, Fu J, Chen M, Zhu H, Roher A, Slattery T, Zhao L, Nagashima M, Morser J,  Migheli A, Nawroth P, Stern D and Schmidt AM. RAGE and amyloid-beta peptide neurotoxicity in Alzheimer’s disease. Nature 382: 685-691, 1996
26. Yan SD, Yan SF, Chen X, Fu J, Chen M, Kuppusamy P, Smith MA, Perry G, Godman GC, Nawroth P, Zweier JL and Stern D: Non-enzymatically glycated tau in Alzheimer’s disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid beta-peptide. Nature Medicine 1 (7): 693 -699, 1995