Prof. George Perry

Biology, University of Texas at San Antonio, USA

Dean and Professor

Email: George.Perry@utsa.edu

Qualifications

1973   A.A., Allan Hancock College, Santa Maria, USA
1974   B.A., Zoology,University of California at Santa Barbara, USA
1979   Ph.D., Marine Biology, University of California at San Diego, USA

Publications (Selected)

1. Wang X, Perry G, Smith MA, Zhu X.  Amyloid-β-derived diffusible ligands cause impaired axonal transport of mitochondria in neurons.  Neurodegener Dis 1:56-59, 2010.(1) 
2. Borghi R, Piccini A, Barini E, Cirmena G, Guglielmotto M, Tamagno E, Fornaro M, Perry G, Smith MA, Garuli A, Tabaton M.  Up-regulation of Presenilin 1 in brains of sporadic, late-onset Alzheimer disease.  J Alzheimer's Disease 22:771-775, 2010. 
3. Gustaw-Rothenberg KA, Siedlak SL, Bonda DJ, Lerner A, Tabaton M, Perry G, Smith MA.  Dissociated amyloid-β antibody levels as a serum biomarker for the progression of Alzheimer’s disease: a population study.  Exp Gerontol 45:47-52, 2010.(2) 
4. Smith MA, Zhu X, Tabaton M, Liu G, McKeel DW Jr, Cohen ML, Wang X, Siedlak SL, Hayashi T, Nakamura M, Nunomura A, Perry G.  Increased iron and free radical generation in preclinical Alzheimer disease and mild cognitive impairment.  J Alzheimer Dis 19:363-372, 2010.(17) 
5. Su B, Wang X, Lee H-g, Tabaton M, Perry G, Smith MA, Zhu X.  Chronic oxidative stress causes increased tau phosphorylation in M17 neuroblastoma cells.  Neurosci Lett 468:267-271, 2010. (1) 
6. Nunomura A, Tamaoki T, Tanaka K, Motohashi N, Nakamura M, Hayashi T, Yamaguchi H, Lee H-g, Zhu X, Smith MA, Perry G.  Intraneuronal Amyloid β accumulation and oxidative damage to nucleic acids in Alzheimer disease. Neurobiol Dis 37:731-737, 2010.(4) 
7. Nair NG, Perry G, Smith MA, Reddy VP.  NMR studies of zinc, copper, and iron binding to histidine, the principal metal ion complexint site of amyloid-β peptide. J Alzheimer Dis 20:57-66, 2010.(1) 
8. Poeggeler B, Sambamurti K, Siedlak SL, Perry G, Smith MA, Pappolla MA.  A novel endogenous indole protects rodent mitochondria and extends rotifer lifespan. PLOS One 5:e10206. doi:10.1371/journal.pone.0010206, 2010. 
9. Storace D, Cammarata S, Borghi R, Sanguineti R, Giliberto L, Piccini A, Pollero V, Novello C, Caltagirone C, Smith MA, Bossù P, Perry G, Odetti P, Tabaton M.  Elevation of β-amyloid 1-42 autoantibodies in the blood of amnestic patients with mild cognitive impairment.  Arch Neurol 67:867-72, 2010. 
10. Nakamura M, Shishido N, Nunomura A, Smith MA, Perry G, Akutsu H, Hayashi T.  Specific reaction of Met 35 in amyloid beta peptide with hypochlorous acid. Free Radic Res 44:734-741, 2010. 
11. Moh C, Siedlak SL, Tabaton M, Perry G, Castellani RJ.  Paraffin-embedded tissue (PET) blot method:  application to Alzheimer disease.  J Neurosci Meth 190:244-247, 2010. 
12. Valdez CH, Smith MA, Perry G, Phelix CF, Santamaria F.  Cholesterol homeostasis markers are localized to mouse hippocampal pyramidal and granule layers. Hippocampus 20:902-905, 2010. 
13. Zou W-Q, Puoti G, Xiao X, Yuan J, Cali I, Shimoji M, Qing L, Langeveld JPM, Castellani R, Notari S, Troncoso J, Schmidt RE, Geschwind M, DeArmond SJ, Cairns N, Morris J, Dickson D, Honig L, Capellari S, Giaccone G, Belay ED, Schonberger LB, Perry G, Kong G, Parchi P, Tagliavini F, Gambetti P.  Variable protease-sensitive prionopathy:  a new sporadic disease of the prion protein. Ann Neurol 68:162-172, 2010.(1) 
14. Buxton GA, Siedlak SL, Perry G, Smith MA.  Mathematical modeling of microtubule dynamics: insights into physiology and disease.  Prog Neurobiol 92:478-483, 2010. 
15. Heath, JE. Siedlak SL, Zhu X, Lee H-g, Thakur A, Yan R, Perry G, Castellani R, Smith MA.  Widespread distribution of reticulon-3 in various neurodegenerative diseases.  Neuropathology 30:574-579, 2010. 
16. Bonda DJ, Mailankot M, Stone JG, Garrett MR, Staniszewska M, Castellani RJ, Siedlak SL, Zhu X, Lee H-g, Perry G, Nagaraj RH, Smith MA.  Indoleamine 2,3-dioxygenase and 3OH-kynurenine modifications are found in the neuropathology of Alzheimer disease.  Redox Report 15:161-168, 2010. 
17. Castellani RJ, Nugent SL, Morrison AL, Zhu X, Lee H-g, Harris PLR, Bajić V, Sharma HS, Chen SG, Oettgen P, Perry G, Smith MA.  CD3 in Lewy pathology: does the abnormal recall of neurodevelopmental processes underlie Parkinson’s disease.  J Neural Transm 118:23-26, 2011. 
18. Colom LV, Castaneda MT, Hernandez S, Perry G, Jaime S, Touham A.  Intrahippocampal amyloid-β (1-40) injections injure medial septal neurons.  Curr Alzheimer Res 8:(in press), 2011. 
19. Castellani RJ, Gupta Y, Sheng B, Siedlak SL, Harris PLR, Coller JM, Perry G, Lee H-g,  Tabaton M, Smith MA, Wang X, Zhu X.  A novel origin for granulovacuolar degeneration in aging and Alzheimer’s disease:  parallels to stress granules.  Lab Invest 91:1777-1786, 2011. 
20. Stone JG, Siedlak SL, Tabaton M, , Hirano A, Castellani RJ, Santocanale C, Perry G, Smith MA, Zhu X, Lee H-g.  The cell cycle regulator, phosphorylated retinoblastoma protein, is associated with tau pathology in several tauopathies. J Neuropathol Exp Neurol 70:578-587, 2011. 
21. Zhu X, Castellani RJ, Moreira PI, Aliev G, Shenk JC, Siedlak SL, Harris PLR, Fujioka H, Sayre LM, Szweda PA, Szweda LI, Smith MA, Perry G. Hydroxynonenal-generated crosslinking fluorophore accumulation in Alzheimer disease reveals a dichotomy of protein turnover.  Free Rad Biol Med 52:699-704, 2012. 
22. Nunomura A, Tamaoki T, Motohashi N, Nakamura M, McKeel Jr. DW, Lee H-g, Zhu X, Smith MA, Perry G.  Neuronal RNA oxidation during aging process and in preclinical Alzheimer disease and mild cognitive impairment.  J Neuropathol Exp Neurol (in press), 2012. 
23. Calderón-Garcidueñas L, Kavanaugh M, Block M, D’Angiulli A, Delgado-Chάvez R, Torres-Jardón R, González-Maciel A, Reynoso-Robles R, Perry G, Osnaya N, Villarreal-Calderon R, Guo R, Hua Z, Zhu H, Perry G, Diaz P.  Neuroinflammation, Alzheimer’s-associated pathology and down-regulation of the prion-related protein in air pollution exposed children and young adults. J Alzheimer’s Dis 28: (in press), 2012. 
24. Valdez CM, Phelix CF, Smith MA, Perry G, Santamaria F.  Modeling cholesterol metabolism by gene expression profiling in the hippocampus. Molecular Biosystems 7:1891-1901, 2011. 
25. Gugliemotto M, Aragno M, Tamagno E, Vercellinatto I, Visentin S, Medana C, Catalano MG, Smith MA, Perry G, Danni O, Boccuzzi G, Tabaton M.  AGEs/RAGE complex upregulates BACE1 via NF-kappaB pathway activation Neurobiol Aging 33 (in press), 2012. 
26. Wang X, Su B, Liu W, He X, Gao Y, Castellani RJ, Perry G, Smith MA, Zhu X.  DLP1-dependent mitochondrial fragmentation mediates 1-methyl-4-phenylpyridinum toxicity in neurons:  implications for Parkinson’s disease. Aging Cell 10:807-823, 2011. 
27. Wise-Scira O, Xu L, Kitahara T, Perry G, Coskuner O.  Amyloid-β peptide structure in aqueous solution varies with fragment size.  J Chem Phys 135:205101-1–205101-13, 2011 (Virtual J Biol Phys Res, 22(11), 2011). 
28. Sheng B, Wang X, Su B, Lee H-G, Casadesus G, Perry G, Zhu X.  Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer’s disease.  J Neurochem 120:419-429, 2012. 
29. Phelix CF, LeBaron RG, Roberson DJ, Villanueva RE, Villareal G, Rahimi OB, Siedlak S, Zhu X, Perry G.  Transcription-to-metabalome biosimulation reveals human hippocampal hypometabolism with age and Alzheimer’s disease.  Intern J Knowledge Discovery Bioinformatics 2:1-18, 2011.
30. Kudo W, Lee H-P, Zou W-Q, Perry G, Zhu X, Smith MA, Petersen RB, Lee H-G.  Cellular prion protein is essential for oligomeric amyloid-β-induced neuronal cell death. Human Mol Genetics (in press). 
31. Wang X, Fujioka H, Yan M, Liu J, Perry G, Casadesus G, Zhu X.  LRRK2 regulates mitochondrial dynamics and function in neurons through direct interaction with DLP1. Human Mol Genetics (in press).