Dr. Joy Sinha
ANDalyze, Inc., USA
Email: jsinh2@gmail.com
Qualifications
2011-Present Scientist,
ANDalyze, Inc., USA
2006-2011 Postdoctoral Fellow, Emory
University, USA
2001-2006 Doctoral Candidate, University of Kentucky, USA
2000-2001 Junior Research Fellow, Indian Institute of Technology, India
Publications (Selected)
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Sinha, J., Topp, S. & Gallivan,
J.P. From SELEX to Cell: Dual Selections for Synthetic riboswitches. Methods
Enzymol. 497, 207-220 (2011).
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Sinha, J., Reyes, S.J. & Gallivan,
J.P. Reprogramming bacteria to seek and destroy an herbicide. Nat. Chem. Biol. 6,
464-470 (2010).
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This research has been listed among
the key discoveries in chemical biology of the past decade by Nature Chemical
Biology. Also mentioned in "Breakthrough of the Year" feature.
Science magazine's
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Sinha, J., Dotson, P.P. & Testa,
S.M. Kinetic characterization of the first step of the ribozyme-catalyzed trans
excision-splicing reaction. FEBS J. 275, 3110-3122 (2008).
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Dotson, P.P., Sinha, J. &
Testa, S.M. A Pneumocystis carinii group I intron-derived ribozyme utilizes an
endogenous guanosine as the first reaction step nucleophile in the trans
excision-splicing reaction. Biochemistry 47, 4780-4787 (2008).
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Johnson, A.K., Sinha, J. &
Testa, S.M. Trans Insertion-Splicing: Ribozyme catalyzed insertion of targeted
sequences into RNAs. Biochemistry 44, 10702-10710 (2005).
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Sinha, J., Baum, D.A. & Testa,
S.M. Molecular recognition in a trans excision-splicing ribozyme:
Non-Watson-Crick base pairs at the 5′-splice site and ωG at the 3′-splice site
can play a role in determining the binding register of reaction substrates.
Biochemistry 44, 1067-1077 (2005). (Joint first author)
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Bell, M.A., Sinha, J., Johnson,
A.K. & Testa, S.M. Enhancing the second step of the trans excision-splicing
reaction of a group I ribozyme by exploiting P9.0 and P10 for intermolecular
recognition. Biochemistry 43, 4323-4331 (2004).
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Sinha, J., Layek, S., Mandal, G.C.
& Bhattacharjee, M. A green Hünsdiecker reaction: synthesis of
β-bromostyrenes from the reaction of α, β-unsaturated aromatic carboxylic acids
with KBr and H2O2 catalyzed by Na2MoO4. H2o in aqueous medium. Chem. Comm. 19,
1916-1917 (2001).