Dr. Nicholas Brook
University of Adelaide
Australia
Email: nicholasbrook@fastmail.fm
Qualifications
Bachelor of Science in Animal Physiology, Queen Mary College, University of London, 1988~1991;
Master of Science in Biochemical Pharmacology, University of Southampton, 1991~1992;
Bachelor of Medicine Accelerated Course, University of Southampton, 1992~1996;
Doctor of Medicine, University of Leicester. 2006
Selected Publications
S Khan, NR Brook, R Whelpton, AT Michael-Titus. SP (1-7) and SP (5-11) locally modulate dopamine release in rat striatum. Eur J Pharmacol. 1995; 282: 229-33
NR Brook. The balance between service and training. Ann R Coll Surg Eng. 2002;(Suppl) 84:15-17
NR Brook, JR Waller, CJ Pattenden, ML Nicholson. Ureteric stenosis after renal transplantation:no effect of acute rejection or immunosuppression. Transplant Proc. 2002; 34(7):3007-8
NR Brook, JR Waller, ML Nicholson. Non-heart-beating kidney donation: Current practice and future developments. Kidney Int. 2003; 63:1516-1529
NR Brook, SA White, JR Waller, GR Bicknell, ML Nicholson. Fibrosis associated geneexpression in renal transplant glomeruli after acute renal allograft rejection. Br J Surg. 2003;90:1009-1014
NR Brook, SA White, JR Waller, PS Veitch, ML Nicholson. Non-heart beating donor kidneyshave superior rates of graft survival compared to conventional heart-beating donor kidneys that develop delayed graft function. Am J Transplant. 2003; 3(5): 614-618
NR Brook, AJ Knight, ML Nicholson. Intra-renal resistance reflects warm ischaemic damage and is further increased by static cold storage: A model of non-heart-beating donor kidneys. Medical Science Monitor 2003; 9(7): 271-275
NR Brook, ML Nicholson. Kidney transplantation from non heart-beating donors. Surg J R Coll Surg Edinb Irel. 2003; 1(6):311-322
NR Brook, ML Nicholson. Laparoscopic live donor nephrectomy. Leading Article. Br J Surg. 2003; 90(11):1313-1314
JR Waller, NR Brook, ML Nicholson. Cardiac Allograft Vasculopathy – Current concepts and treatment. Transplant Int. 2003; 16(6): 367-375
NR Brook, SA White, JR Waller, ML Nicholson. The surgical management of peritoneal dialysis catheters. Ann R Coll Surg Eng. 2004; 86(3):190-5
NR Brook, ML Nicholson. An audit over two years practice of open and laparoscopic live donor nephrectomy at renal transplant centres in the UK and Ireland. BJU Int. 2004; 93:1027-1031
NR Brook, JR Waller, AC Richardson, M Gok, JA Bradley, PA Andrews, G Koffman, D Talbot, ML Nicholson. A report on the activity and clinical outcomes of renal non-heart beating donor transplantation in the United Kingdom from 1988 to 2001. Clin Transplant. 2004; 18(6):627-633
JR Waller, NR Brook, GR Bicknell, ML Nicholson. Differential effects of modernimmunosuppressive agents on the development of intimal hyperplasia. Transplant Int. 2004; 17(1):9-14
GRR Lewis, NR Brook, JR Waller , JC Bains, PS Veitch, ML Nicholson. A comparison of traditional open, minimal incision donor nephrectomy and laparoscopic donor nephrectomy. Transplant Int. 2004; 17(10):589-595
GRR Lewis, K Mulchay, NR Brook, PS Veitch, ML Nicholson. A prospective study of the predictive power of spiral CT angiography in delineating renal vascular anatomy for live donor nephrectomy. BJU Int. 2004; 94(7):1077-81
ML Nicholson, SA Hosgood, MS Metcalfe, JR Waller, NR Brook. A comparison of renal preservation by cold storage and machine perfusion using a porcine autotransplant model. Transplantation 2004; 78(3):333-337
NR Brook, JR Waller, GR Bicknell, ML Nicholson. The experimental agent pirfenidone reduces pro-fibrotic gene expression in a model of tacrolimus-induced nephrotoxicity. J Surg Res. 2005;125(2): 137-143
NR Brook, JR Waller, GR Bicknell, ML Nicholson. Prograf produces a molecular environment favouring antifibrosis, an effect reversed by the addition of Rapamune. Transplant Proc. 2005; 37(1): 148-9
NR Brook, SJ Harper, R Elwell, A Bagul, ML Nicholson. Laparoscopic donor nephrectomy yieldskidneys with structure and function equivalent to those retrieved by open surgery. Transplanta Proc 2005; 37(2): 625-626
NR Brook, ML Nicholson. Alterations in the practice of open and laparoscopic live donor nephrectomy at renal transplant centres in the UK and Ireland. Transplant Proc. 2005; 37(2): 623-624
NR Brook, JR Waller, GR Bicknell, ML Nicholson. Cyclosporine and rapamycin act in a synergistic and dose dependent manner in a model of immunosuppressant-induced kidney damage.
NR Brook, SJ Harper, JR Waller, R Elwell, ML Nicholson. A consecutive series of 70 laparoscopic donor nephrectomies demonstrates the safety of this new operation. Transplant Proc.2005; 37(2): 627-628
NR Brook, JR Waller, GR Bicknell, ML Nicholson. The novel antifibrotic agent pirfenidone attenuates the pro-fibrotic environment generated by calcineurin-inhibitors in the rat salt-depletion model. Transplant Proc. 2005; 37(1): 130-3
Wilson CH, Brook NR, Gok MA, Asher JF, Nicholson ML, Talbot D. Randomized clinical trial of daclizumab induction and delayed introduction of tacrolimus for recipients of non-heart-beating kidney transplants. Br J Surg. 2005; 92(6):681-7
Wilson C, Brook NR, Gok MA, Gupta A, Asher JF, Nicholson ML, Talbot D. Evaluation of daclizumab to reduce delayed graft function in non-heart-beating renal transplantation: a prospective, randomized trial. Transplant Proc. 2005 May;37(4):1774-5
JR Waller, NR Brook, GR Bicknell, GJ Murphy, ML Nicholson. Mycophenolate mofetil inhibits intimal hyperplasia and attenuates the expression of genes favouring smooth muscle cell proliferation and migration. Transplant Proc. 2005; 37(1):164-6
JC Bains, RM Sandford, NR Brook, SA Hosgood, GRR Lewis, ML Nicholson. A comparison of renal allograft fibrosis following transplantation from heart beating and non-heart beating donors.Br J Surg. 2005; 92(1):113-118
NR Brook, ML Nicholson. Minimally invasive surgery for live kidney donors; techniques and challenges. Progress in Transplantation 2005; 15(3): 257-63
NR Brook, CH Wilson, ML Nicholson. Current Status of Live Donor Renal Transplantation. Therapy 2005; 2(6):909-920
NR Brook, AJ Colquhoun, JK Mellon. Management of transitional cell carcinoma by targeting the epidermal growth factor receptor. Therapy 2006; 3(3):407-416
Bagul A, Brook NR, Harper SJ, Nicholson ML. Vascular clamping of calcified vessels: the peanut technique. Ann R Coll Surg Engl. 2006 Jan;88(1):77
A Bagul, R Taha, MS Metcalfe, NR Brook, ML Nicholson. Pre incision-infiltration of local anesthetic reduces postoperative pain with no effects on bruising and wound cosmesis after thyroid surgery. Thyroid 2005; 15(11):1245-1248
CH Wilson, NR Brook, D Talbot. Preservation solutions for solid organ transplantation. Mini-Reviews in Medicinal Chemistry 2006; 6(10): 1081-1090