Prof. Tiziano Tuccinardi
Department
of Pharmacy
University of Pisa, Italy
Associate Professor
Email: tiziano.tuccinardi@farm.unipi.it
Qualifications
2015 Associate
Professor, Department of Pharmacy,
University of Pisa
2014 Adjunct Assistant Professor, Sbarro Institute for
Cancer Research and Molecular Medicine, Center for Biotechnology, Temple
University, USA
2009 Assistant Professor, Department of Pharmacy, University
of Pisa, Italy
2006 Ph.D., Computational Chemistry, University of Pisa, Italy
2002 MD, Medicinal
Chemistry, University of Pisa,
Italy
Publications (selected)
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Poli G, Giuntini N, Martinelli A, Tuccinardi T.
“Application of a FLAP-Consensus Docking Mixed Strategy for the Identification
of New FAAH Inhibitors” J Chem Inf Model. 2015 55(3):667-675.
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Granchi C, Capecchi A, Del Frate G, Martinelli A,
Macchia M, Minutolo F, Tuccinardi T. “Development and Validation of a
Docking-Based Virtual Screening Platform for the Identification of New Lactate
Dehydrogenase Inhibitors” Molecules. 2015, 20(5):8772-8790.
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Tuccinardi T, Poli G, Romboli V, Giordano A,
Martinelli A. “Extensive consensus docking evaluation for ligand pose
prediction and virtual screening studies” J Chem Inf Model. 2014, 54(10):2980-2986.
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Tuccinardi T, Granchi C, Rizzolio F, Caligiuri I,
Battistello V, Toffoli G, Minutolo F, Macchia M, Martinelli A. “Identification
and characterization of a new reversible MAGL inhibitor” Bioorg Med Chem. 2014,
22(13):3285-3291.
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Wong CH, Nguyen L, Peh J, Luu LM, Sanchez JS,
Richardson SL, Tuccinardi T, Tsoi H, Chan WY, Chan HY, Baranger AM,
Hergenrother PJ, Zimmerman SC. “Targeting Toxic RNAs that Cause Myotonic
Dystrophy Type 1 (DM1) with a Bisamidinium Inhibitor.” J Am Chem Soc.
2014, 136(17):6355-6361.
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Fusi C,
Materazzi S, Benemei S, Coppi E, Trevisan G, Marone I, Minocci D, De Logu F,
Tuccinardi T, Di Tommaso M, Susini T, Moneti G, Pieraccini G, Geppetti P,
Nassini R. “Steroidal and non-steroidal third-generation aromatase inhibitors
induce pain-like symptoms via TRPA1” Nature
Communications 2014, 5:5736.
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Tuccinardi T,
Granchi C, Iegre J, Paterni I, Bertini S, Macchia M, Martinelli A, Qian Y, Chen
X, Minutolo F. “Oxime-based inhibitors of glucose transporter 1 displaying
antiproliferative effects in cancer cells.” Bioorg Med Chem. Lett. 2013,
23(24):6923-6927.
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Poli G, Tuccinardi T, Rizzolio F, Caligiuri I, Botta
L, Granchi C, Ortore G, Minutolo F, Schenone S, Martinelli A. “Identification
of new FYN kinase inhibitors using a FLAP-based approach.” J Chem Inf Model.
2013, 53(10):2538-2547.
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Tuccinardi T,
Bertini S, Granchi C, Ortore G, Macchia M, Minutolo F, Martinelli A, Supuran
CT. “Salicylaldoxime derivatives as new
leads for the development of Carbonic Anhydrase inhibitors” Bioorg Med Chem.
2013, 21(6):1511-1515.
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Marques SM,
Tuccinardi T, Nuti E, Santamaria S, André V, Rossello A, Martinelli A, Santos
MA. “Novel 1-hydroxypiperazine-2,6-diones
as new leads in the inhibition of metalloproteinases.” J Med Chem. 2011,
54(24):8289–8298.
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Tuccinardi T, Zizzari AT, Brullo C,
Daniele S, Musumeci F, Schenone S, Trincavelli ML, Martini C, Martinelli A,
Giorgi G, Botta M. “Substituted pyrazolo[3,4-b]pyridines as human A(1)
adenosine antagonists: Developments in understanding the receptor
stereoselectivity.” Org Biomol Chem. 2011, 9(12):4448-4455.
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Granchi C, Roy S, Giacomelli C, Macchia
M, Tuccinardi T, Martinelli A, Lanza M, Betti L, Giannaccini G, Lucacchini A,
Funel N, León LG, Giovannetti E, Peters GJ, Palchaudhuri R, Calvaresi EC,
Hergenrother PJ, Minutolo F. “Discovery of N-Hydroxyindole-Based Inhibitors of
Human Lactate Dehydrogenase Isoform A (LDH-A) as Starvation Agents against
Cancer Cells.” J Med Chem. 2011, 54(6):1599-1612.
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Tuccinardi T, Botta M, Giordano A,
Martinelli A. “Protein
Kinases: Docking and Homology Modeling Reliability.” J Chem Inf Model. 2010,
50(8):1432-1441.
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Tuccinardi T, Taliani S, Bellandi M, Da
Settimo F, Da Pozzo E, Martini C, Martinelli A. “A virtual screening
study of the 18-kDa translocator protein using pharmacophore models combined
with 3D-QSAR studies” ChemMedChem
2009, 4(10):1686-1694.
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Tuccinardi T.
“Docking-Based Virtual Screening: Recent Developments” Comb. Chem. High Throughput Screen. 2009, 12(3):303-314.
Profile Details:
http://www.mmvsl.it/wp/group-members/tuccinardi/