Dr. Jithesh Kottur
Icahn School of Medicine at Mount Sinai, New York, USA
Post-doctoral Fellow
Email: jithesh.kottur@mssm.edu
Qualifications
2017 Ph.D., Regional Centre for Biotechnology, India.
2011 M.Sc., Kannur University, India.
Publications (Selected)
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Yu,X., Li,D., Kottur,J., Shen,Y., Kim,H.S., Park,K.-S., Tsai,Y.-H., Gong,W., Wang,J., Suzuki,K., et al. (2021) A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models. Sci Transl Med, 13, eabj1578. (Equal Contribution).
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Johnson, M.K., Kottur, J and Nair, D.T. (2019) A polar filter in DNA polymerases prevents ribonucleotide incorporation Nucleic Acids Res. 47, 10693-10705.
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Kottur, J and Nair, D. T. (2018) Pyrophosphate hydrolysis is an intrinsic and critical step of the DNA synthesis reaction. Nucleic Acids Res.46, 5875-5885.
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Kottur, J. and Nair, D.T. (2016) Reactive Oxygen Species Play an Important Role in the Bactericidal Activity of Quinolone Antibiotics. Angew Chem Int Ed Engl, 55, 2397-2400.
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Ghodke, P.P., Gore, K.R., Harikrishna, S., Samanta, B., Kottur, J., Nair, D.T. and Pradeepkumar, P.I. (2016) The N(2)-Furfuryl-deoxyguanosine Adduct Does Not Alter the Structure of B-DNA. J Org Chem, 81, 502-511.
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Weinert, T., Olieric, V., Waltersperger, S., Panepucci, E., Chen, L., Zhang, H., Zhou, D., Rose, J., Ebihara, A., Kuramitsu, S., Kottur, J. et al. (2015) Fast native-SAD phasing for routine macromolecular structure determination. Nature Methods, 12, 131-133.
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Kottur, J., Sharma, A., Gore, K.R., Narayanan, N., Samanta, B., Pradeepkumar, P.I. and Nair, D.T. (2015) Unique structural features in DNA polymerase IV enable efficient bypass of the N2 adduct induced by the nitrofurazone antibiotic. Structure, 23, 56-67.
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Nair, D.T., Kottur, J. and Sharma, R. (2015) A rescue act: Translesion DNA synthesis past N(2) -deoxyguanosine adducts. IUBMB Life, 67, 564-574.
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Sharma, A., Kottur, J., Narayanan, N. and Nair, D.T. (2013) A strategically located serine residue is critical for the mutator activity of DNA polymerase IV from Escherichia coli. Nucleic acids research, 41, 5104-5114.
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Khan, M. and Jithesh, K. (2012) Expression and purification of organic solvent stable lipase from soil metagenomic library. World J Microbiol Biotechnol, 28, 2417-2424.
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Khan, M., Jithesh, K. and Mookambikay, R. (2013) Cloning and characterization of two functionally diverse lipases from soil metagenome. J Gen Appl Microbiol, 59, 21-31.
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