Author(s)

B. O. Muyiwa^1*, N. S. Emmanuel², F. M. Yahuza², M. Aliyu³, C. U. Inegbenosun⁴, I. Musah²

¹Department of Veterinary Pathology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria.
²Department of Human Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, Ahmadu Bello University Zaria, Kaduna State, Nigeria.
³School of Post Basic ORL Nursing National Ear Care Center, Kaduna, Nigeria.
⁴Department of Zoology, Faculty of Natural Science, Ambrose Alli University, Ekpoma Edo State, Nigeria.

The experiment was conducted to evaluate the acute toxicity of aqueous extract of Adenium obesum stem bark in juveniles of Clarias gariepinus by assessing the hematological responses of the exposed groups compared to the control in a static non-renewal bioassay for 96 hours. The fishes (N = 180, mean weight and length 21.48 ± 3.32 g and 11.37 ± 1.23 cm) respectively were randomly distributed 10 (ten) fishes per group in triplicates constituting six experimental groups as follows; G1 (Control), G2 (6.5 mg/l), G3 (7.8 mg/l), G4 (8.5 mg/l), G5 (9.5 mg/l) and G6 (11.5 mg/l). Red blood cell (RBC) count, packed cell volume (PCV) and hemoglobin concentration were decreased significantly (P < 0.05) as opposed to the significant (P < 0.05) increase in total white blood cell count (TWBC). Thus the study concludes that aqueous extract of Adenium obesum stem bark is toxic to erythrocytes while a converse adaptive response in the white blood cells.

Adenium obesum, Clarias gariepinus, Hematology, Toxicity

Muyiwa, B. , Emmanuel, N. , Yahuza, F. , Aliyu, M. , Inegbenosun, C. and Musah, I. (2020) Physico-Chemical Evaluation and Hematological Responses in Clarias gariepinus (Burchell 1822) Juveniles Exposed to Adenium obesum Stem Bark Acute Bioassay. Advances in Biological Chemistry, 10, 43-54. doi: 10.4236/abc.2020.102004.