Author(s)

Faten Ayoob Tayeb¹, Yahay Jirjees Salman^2*, Khalidha Mohammad Ameen³

¹Biology Department, M.Sc. College of Science-Kirkuk University, Kirkuk, Iraq.
²Department of Medical Microbiology and Immunology, Ph.D. Microbiology, Kirkuk Medical College, Kirkuk, Iraq.
³Department of Gynecology and Obstetric-Kirkuk Medical College, Ph.D. Gynecology and Obstetric, Kirkuk Medical College, Kirkuk, Iraq.

Background: Toxoplasmosis had a remarked role in disturbing pregnancy in women by abortions and congenital abnormalities outcome .Vitamin D deficiency had a role in bone fragility, osteoporosis, exposing women to fractures as well as to bone deformities in newborns. Objective: To assess the relationship between toxoplasmosis seropositivity and vitamin D abnormalities in sera of women in childbearing ages using ELISA and auto-analyzers. Methodology: A cross-sectional study was conducted by examining the sera of 153 women, who visited Azadi Teaching Hospital Gynecological and Obstetric Clinics. Their complaints involve signs of bad obstetric history (BOH) and bone disorders, versus to 46 women negative for (BOH). Their ages ranged from 15 to 50 years. The results: The overall rate of positive toxoplasmosis was 78.43% distributed into the following rates: 22.87%, 49.01%, and 13.07% for IgM, IgG, and IgM + IgG antibodies, P < 0.05. Whereas the examination of sera in the control group reveals only 14 sera positive for IgG Abs, the rate was 31.12%. Sera from women in the early childhood age bearing exerts high rates of T. gondii IgM than in sera of women aged over 46 years, P < 0.05. Non-animal contact women sera reveal higher rates of T. gondii Abs than in contact women. The relationship between toxoplasmosis, urinary tract infection (UTI) and arthritis was significant. Women with previous single abortion reveal high rates of toxoplasmosis compared to multi-abortion. The impact of toxoplasmosis concerning serum vitamin D3 levels denoted as vitamin D3 deficiency in both two groups. Conclusions: The rate of toxoplasmosis among childbearing age women was high, and the relationship between toxoplasmosis and vitamin D deficiency was significant. This finding is preliminary and prone women for getting osteoporosis.

Toxoplasmosis, Vitamin D, Congenital, Bad Obstetric History, Arthritis

Tayeb, F. , Salman, Y. and Ameen, K. (2019) The Impact of Toxoplasma gondii Infection on the Vitamin D3 Levels among Women in Childbearing Age in Kirkuk Province-Iraq. Open Journal of Medical Microbiology, 9, 151-167. doi: 10.4236/ojmm.2019.94015.