Gut Lymphangiopathy: Adding Fuel to the Fire in Chronic Liver Disease - Advances in Bioscience and Biotechnology

ABB > Vol.10 No.10, October 2019

Gut Lymphangiopathy: Adding Fuel to the Fire in Chronic Liver Disease ()

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Download as PDF (Size: 1051KB) PP. 305-319

DOI: 10.4236/abb.2019.1010024 484 Downloads 1,124 Views

Author(s)

Luis Tresierra¹, Maria-Angeles Aller^2*, Isabel Prieto³, Luis Santamaria⁴, Jaime Arias²

Affiliation(s)

¹Department of Surgery, Sant Joan Despi Moises Broggi Hospital, Barcelona, Spain.
²Department of Surgery, School of Medicine, Complutense University of Madrid, Madrid, Spain.
³Department of General and Digestive Surgery, La Paz Hospital, Autonoma University of Madrid, Madrid, Spain.
⁴Department of Anatomy, Histology and Neuroscience, School of Medicine, Autonoma University of Madrid, Madrid, Spain.

ABSTRACT

The splanchnic inflammation inchronic liver disease increases intestinal angiogenesis. In the current study our aim was demonstrating that the small bowel lymphangiogenesis is associated with angiogenesis in chronic cholestasis in the rat. A stereological study of the lymphatic microcirculation in the small intestine was performed in cholestatic rats. Portal enteropathy in cholestasis increases lymphatic microvessels in the mucosa and submucosa layers. Thus, the lymphatic microvessel volume fraction was superior (p < 0.001) in the mucosa (0.16 ± 0.01) and submucosa (0.16 ± 0.01), in regard to the muscle layer 0.015 ± 0.01. The lymphatic microvessel length density was higher in the mucosa (76.89 ± 2.86 mm^-2; p < 0.001) and submucosa (14.87 ± 2.86 mm^-2; p < 0.01), in relationship to the muscle layer (5.04 ± 2.92 mm^-2). These alterations predominate in the duodenum (volume fraction: 0.10 ± 0.01 and length density: 33.55 ± 5.98 mm^-2) and ileum (volume fraction: 0.16 ± 0.01 and length density: 38.62 ± 6.07 mm^-2). This study demonstrates the predominance of an increased lymphangiogenic response in both end sides of the small bowel associated with chronic liver disease. Since the porto-systemic venous collateral circulation in the chronic liver insufficiency is developed in the ends of the gastrointestinal tract, the excessive duodeno-ileal lymphangiogenesis could suggest the development of amesenteric-systemic lymphatic bypass in the chronic portal hypertension.

KEYWORDS

Chronic Liver Disease, Lymphangiogenesis, Microsurgery, Collateral LymphaticCirculation

Share and Cite:

Tresierra, L. , Aller, M. , Prieto, I. , Santamaria, L. and Arias, J. (2019) Gut Lymphangiopathy: Adding Fuel to the Fire in Chronic Liver Disease. Advances in Bioscience and Biotechnology, 10, 305-319. doi: 10.4236/abb.2019.1010024.

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