Author(s)

Selly Ba^1,2, Ndeye Diama Ba³, Lamanatou Sembene³, Habibatou Dia³, Mohamed Coulibaly⁴, Jean Louis Ndiaye¹, Ndeye Méry Dia⁵, Cheikh Tidiane Ndour⁴

¹Doctoral School of Thies University, Thies, Senegal.
²Intrahealth International, Dakar, Senegal.
³Roi Baudouin Hospital, Dakar, Senegal.
⁴AIDS Monitoring Unit/Ministry of Health, Dakar, Senegal.
⁵Department of Health, Gaston Berger University, Saint Louis, Senegal.

Introduction: In Senegal, the decentralization of Health Care Centers has contributed significantly to the intensification of antiretroviral treatment. However, Care providers are still facing the treatment optimizing challenge. Objectives: To determine the prevalence of virologic failures of PLHIV monitored in a decentralized Health care center and to determine associated factors. Patients and Methods: This is a cross-sectional descriptive and analytical study of PLHIV, aged 18 years and over, on first-line treatment, monitored onsite from February 1st to December 31st, 2018. A data collection form was completed from medical records (clinical, immuno-virologic and evolutionary). Any VL > 1000 cp/ml after 6 months of antiretroviral therapy (ART) was considered as virologic failure. Data were captured and analysed using the EPI INFO 2002software. Chi-square test and the Fisher test were used to compare the proportions; a value of p ≤ 0.05 was considered significant. Results: 331 patients were treated with HIV-1 profile in 89% of cases. A proportion of 55% was married and 97% came from rural areas. 80% were either not or poorly educated. The median of age was 44 ± 11 years with a F/M ratio of 3.4. At baseline, 56% were symptomatic at stage 3 or 4 of WHO. They had severe immunosuppression with a median CD4 count of 217 ± 187 cells/mm³, the viral load was detectable in half of the patients with a median VL of 97,000 cp/ml ± 70,569. The antiretroviral regimen combined 2 NRTIs with 1 NNRTI in 88% of cases. The median of follow-up was estimated at 60 ± 43 months. The prevalence of virologic failure was 19%. This prevalence was associated with age less than 25 years (p = 0.04), late diagnosis (CD4 at baseline less than 200 cel/mm³ (p = 0.002), stage 3 or 4 WHO (p = 0.04) High viral load greater than 10,000 (p = 0.04) at baseline. Conclusion: These results suggest making the new therapeutic classes accessible for first-line treatment.

ART, Virologic Failure, Associated Factors

Ba, S. , Ba, N. , Sembene, L. , Dia, H. , Coulibaly, M. , Ndiaye, J. , Dia, N. and Ndour, C. (2019) Prevalence and Factors Associated with Virologic Failure among People Living with HIV (PLHIV) Monitored in a Decentralized Health Care Facility. Advances in Infectious Diseases, 9, 226-237. doi: 10.4236/aid.2019.93016.