Author(s)

Maindo Alongo Mike-Antoine^1*, Juakali Sihalikyolo¹, Salomon Batina Agasa², Antoine Modia O’yandjo¹, Bernard Mbutu³, Gédéon Katenga Bosunga¹, Jean-Pascal Manga Okenge¹

¹Department of Obstetrics and Gynecology, Faculty of Medicine, University of Kisangani, Kisangani, Democratic Republic of Congo.
²Department of Internal Medicine, Faculty of Medicine, University of Kisangani, Kisangani, Democratic Republic of Congo.
³Intitut Superieur des Techniques Médicales de Kisangani, Ema Esu Laboratory, Kisangani, Democratic Republic of Congo.

Introduction: Antisperm antibodies (ASA) prevalence is high in Kisangani. ASA are one of the male factors of infertility that can reduce spermatozoa motility and cervical penetration or prevent acrosomal reaction and even alter embryo development. This study aims to determine the risk factors of ASA positivity among infertile men in Kisangani. Patient and Method: We conducted a case-control study during a period of 2 years in Kisangani on 111 men who consulted for conception and tested for ASA by ELISA. We did a simple pairing that concerned only the type of infertility. For a better balance between the number of cases and controls per stratum to provide better accuracy in the adjusted OR estimate, we performed a 1:1 match. Results: This study showed that businessmen [ORa = 5.0000(1.2452 - 20.0767)] and jobless [ORa = 5.8125(1.1477 - 29.4367)] were at risk of being positive for ASA. Violent blow to testicles [ORa = 6.7391(1.3455 - 33.7545)], cure of hernia [ORa = 4.3478(1.0722 - 17.6299)], Chlamydia infection [ORa = 4.7125(1.3405 - 16.5665)], leucospermia [ORa = 4.1429(1.0406 - 19.7155)] and presence of Staphylococcus aureus [ORa = 3.4444(0.6410 - 18.5082)] were associated to positive ASA. Conclusion: This study shows that factors that may lead to risky sexual behavior and physical or infectious trauma are important risk factors for ASA positivity. It is therefore necessary to search for them systematically during male infertility in order to guide the search for ASA.

Antisperm Antibody, Chlamydia Trachomatis, Men Infertility, Immune Infertility, Infertility, Democratic Republic of Congo

Mike-Antoine, M. , Sihalikyolo, J. , Agasa, S. , O’yandjo, A. , Mbutu, B. , Bosunga, G. and Okenge, J. (2019) Anti-Sperm Antibodies: Risk Factors of Positive Serology among Infertile Men Patients in Kisangani-Democratic Republic of Congo. Open Journal of Obstetrics and Gynecology, 9, 1130-1141. doi: 10.4236/ojog.2019.98109.