Author(s)

Temitayo O. Aiyelabola^1*, Iyanuoluwa E. Okunade¹, Johan H. L. Jordaan², Daniel P. Otto²

¹Department of Chemistry, Obafemi Awolowo University Ile-Ife, Osun State, Nigeria.
²Research Focus Area for Chemical Resource Beneficiation, Laboratory for Analytical Services; North-West University, Potchefstroom, South Africa.

Coordination compounds of 2-amino-3-methylbutanoic acid were synthesized with chromium(III) and oxovanadium(IV) ions. M:L; 1:2. Adducts of these complexes using 1,10-phenantroline and ethylenediamine were further synthesized, M:L, (1:2). These compounds were characterized using electronic, infra-red spectrophotometry, magnetic susceptibility measurement and percentage metal analyses. The zones of inhibition and minimum inhibitory concentrations of the compounds against eight microbes were studied. The results obtained indicated an octahedral geometry for the Cr(III) complexes, indicative of additional coordination of two water molecules. On the other hand a square pyramid geometry was obtained for the binary oxovanadium complex and its 1,10-phenantroline adduct. However, for the oxovanadium ethylenediamine adduct a distorted octahedral geometry was proposed. The result for the antibacterial studies indicated that both mixed ligand complexes of 1,10-phenantroline exhibited good antibacterial activity, and in some cases better activity than the standard, streptomycin.

Coordination Compounds, 2-Amino-3-Methylbutanoic Acid, Mixed Ligand Complexes, Minimum Inhibitory Concentration, 1, 10-Phenantroline, Ethylenediamine

Aiyelabola, T. , Okunade, I. , Jordaan, J. and Otto, D. (2020) Syntheses of Coordination Compounds of 2-Amino-3-Methylbutanoic Acid Their Mixed Ligand Complexes and Antibacterial Activities. Advances in Biological Chemistry, 10, 67-85. doi: 10.4236/abc.2020.103006.