Influence of coating on the triamcinolone release of alginate chitosan beads for colonic drug delivery

Nadir Veiga Vier, Ruth Meri Lucinda-Silva

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DOI: 10.4236/ns.2011.311122                

Abstract

The aim of this study was to evaluate the effect of coating of alginate-chitosan (AL:CS) beads on the colonic drug delivery. The AL:CS systems containing triamcinolone (TC) were coated with the HPMCP and Eudragit? L100 by immersion and by spraying methods. The drug release profile in simulated colonic medium was determined using 5% human fecal content suspension in 0.01 N buffer solution, pH 6.8. The systems coated with HPMCP showed a lower rate of drug delivery in simulated enteric medium. The delivery profile in simulated colonic medium followed zero-order kinetic. The coated systems provided a promising drug-delivery profile for application in colonic drug delivery.

Keywords

Alginate; Beads; Chitosan; Colon-Specific Drug Delivery; Triamcinolone

Conflicts of Interest

The authors declare no conflicts of interest.

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