Primary breast leiomyosarcoma: case report and literature review

Abstract

PURPOSE: Leiomyosarcoma of the breast is extremely rare. To date, the factors that are predictive of patient prognosis have not been identified. To clarify the nature of leiomyosarcoma of the breast, and also to establish the proper treatment strategy, we report this case We report this case while discussing The Clinical presentation, diagnosis, therapy and pathologic feature. INTRODUCION: Sarcomas comprise less than 1% of all primary breast neoplasms and only a minority of these are leiomyosarcomas. There were only 35 cases being reported in English literature. The mainstay of treatment is surgical excision with clear margins and longterm followup is essential. Its prognosis is better compared to other breast sarcoma. CASE PRESENTATION: We report a case of primary leiomyosarcoma of the breast occurring in young female patient which was successfully treated by surgery and radiotherapy. CONCLUSION: According to literature data, primary leiomyosarcoma is characterized by a better prognosis compared with other breast sarcomas, To date, the factors that are predictive of patient prognosis have not been identified. .The rarity and diagnostic difficulty imposed a multidisciplinary approach.

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M’rabet, F. , kacemi, H. , Mesbahi, O. , Hassouni, K. and Gueddari, B. (2011) Primary breast leiomyosarcoma: case report and literature review. Health, 3, 620-622. doi: 10.4236/health.2011.310104.

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1] Abd El-All, H.S. (2006) Breast spindle cell tumours: About eight cases. Diagnostic Pathology, 1, 13. doi:10.1186/1746-1596-1-13
[2] De la Pena, J, Wapnir, I. (2008) Leiomyosarcoma of the breast in a patient with a 10-year-history of cyclo-phosphamide exposure: A case report. Cases Journal, 1, 301. doi:10.1186/1757-1626-1-301
[3] Cohen, D.T, Oliva, E., Hahn, P.F., Fuller, A.F. Jr., Lee, S.I. (2007) Uterine smooth-muscle tumors with unusual growth patterns: Imaging with pathologic correlation. American Roentgen Ray Society, 188, 246-255. doi:10.2214/AJR.05.1070
[4] Szekely, E., Madaras, L., Kulka, J., Jaraym B., Nagy, L. (2001) Leiomyosarcoma of the female breast. Pathology & Oncology Research, 7, 151-153. doi:10.1007/BF03032583
[5] Munitiz, V., Rios, A., Canovas, J., et al. (2004) Primitive leiomyosarcoma of the breast: case report and review of the literature. Breast, 13, 72-76. doi:10.1016/j.breast.2003.09.004
[6] Wong, L.-C., Huang, P.-C., Luh, S.-P., Huang, C.-S. (2008) Primary leiomyosarcoma of the nipple-areola complex: Report of a case and review of literature. Journal of Zhejiang University: Science B, 9, 109-113. doi:10.1631/jzus.B0720246
[7] Gupta, R.K. (2007) Needle aspiration cytology and immunohistologic findings in a case of leiomyosarcoma of the breast. Diagnostic Cytopathology, 35, 254-256. doi:10.1002/dc.20618
[8] Jayaram, G., Jayalakshmi, P., Yip, C.H. (2005) Leiomyosarcoma of the breast: Report of a case with fine needle aspiration cytologic, histologic and immunohistochemical features. Acta Cytologica, 49, 656-660. doi:10.1159/000326256
[9] Lee, J., Li, S., Torbenson, M., et al. (2004) Leiomyosarcoma of the breast: A pathologic and comparative genomic hybridization study of two cases. Cancer Genetics and Cytogenetic, 149, 53-57. doi:10.1016/S0165-4608(03)00286-3
[10] Stafyla, V.K., Gauvin, J.M., Farley, D.R. (2004) A 53-year-old woman with a leiomyosarcoma of the breast. Current Surgery, 61, 572-575. doi:10.1016/j.cursur.2004.05.008
[11] Liang, W.C., Sickle-Santanello, B.J., Nims, T.A., et al. (2003) Primary leiomyosarcoma of the breast: A case report with review of the literature, The Breast Journal, 9, 494-496. doi:10.1046/j.1524-4741.2003.09613.x

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