Comparative Evaluation of the Anti-ulcer Activity of Curcumin and Omeprazole during the Acute Phase of Gastric Ulcer—Efficacy of Curcumin in Gastric Ulcer Prevention against Omeprazole

Download Download as PDF (Size:1136KB)  HTML   XML  PP. 628-640  
DOI: 10.4236/fns.2011.26088    5,591 Downloads   10,463 Views   Citations


We have confirmed in our laboratory the antiulcer activity of curcumin during the acute chronic phase of gastric ulcer disease at doses of 20, 40 and 80 mg/kg (dissolved in saline solution). In the previous study, the potent effective dose of curcumin was 80 mg/kg that appears a propitious protective effect against gastric ulcer development. Therefore, the comparison between such recommended dose of curcumin and one of the proton pump inhibitors (PPIs) staff is worth-while. Since, the pharmacological control of gastric acid secretion is the main desired goal for gastro-cytoprotection, particularly, the H+/K+-ATPase (acid proton pump) inhibitors. Nevertheless, several studies have indicated that long-term inhibition of gastric acid secretion results in mucosal hyperplasia and carcinoid tumor development, due to increase circulating gastrin levels. Ulcer and the preventive indexes were scored, mucin, juice volume, total acidity, luminal haemoglobin, total antioxidant and total peroxide were evaluated. The pro-inflammatory cytokine IL-6 and the major angiogenic growth factor VEGF levels were measured. Conclusion, curcumin and omeprazole are potentially preventing gastric lesions development in the gastric wall during the acute phase of gastric ulcer diseases, but curcumin was more potent in its effect. Curcumin promotes gastric ulcer prevention/healing by induction of angiogenesis in the granular tissue of ulcers. That may be via upregulation of VEGF expression as reflected from VEGF level in serum and gastric juice, however, omeprazole might be has no role in this story.

Cite this paper

K. Abdul-Aziz, "Comparative Evaluation of the Anti-ulcer Activity of Curcumin and Omeprazole during the Acute Phase of Gastric Ulcer—Efficacy of Curcumin in Gastric Ulcer Prevention against Omeprazole," Food and Nutrition Sciences, Vol. 2 No. 6, 2011, pp. 628-640. doi: 10.4236/fns.2011.26088.


[1] J. L. Wallace and M. N. Muscara, “Selective Cyclo-Oxygenase-2 Inhibitors: Cardiovascular and Gastrointestinal Toxicity,” Digestive and Liver Disease, Vol. 33, Supplement 2, 2001, pp. S21-S28. doi:10.1016/S1590-8658(01)80155-9
[2] I. A. Harsch, T. Brzozowski, K. Bazela, S. J. Konturek, V. Kukharsky, T. Pawlik, E. Pawlowski, E. G. Hahn and P. C. Konturek, “Impaired Gastric Ulcer Healing in Diabetic Rats: Role of Heat Shock Protein, Growth Factors, Prostaglandins and Proinflammatory Cytokines,” European Journal of Pharmacology, Vol. 481, No. 2-3, 2003, pp. 249-260. doi:10.1016/j.ejphar.2003.09.019
[3] J. R. Gum Jr., “Mucin Genes and the Proteins They Encode: Structure, Diversity, and Regulation,” American Journal of Respiratory Cell and Molecular Biology, Vol. 7, No. 6, 1992, pp. 557-564.
[4] Y. Shimizu and S. Shaw, “Cell Adhesion. Mucins in the Mainstream,” Nature, Vol. 366, No. 6456, 1993, pp. 630-631. doi:10.1038/366630a0
[5] U. A. Wittel, A. Goel, G. C. Varshney and S. K. Batra, “Mucin Antibodies—New Tools in Diagnosis and Therapy of Cancer,” Frontiers in Bioscience, Vol. 6, 2001, pp. D1296-D1310. doi:10.2741/Wittel
[6] P. C. Konturek, T. Brzozowski, A. Duda, S. Kwiecien, S. Lober, A. Dembinski, E. G. Hahn and S. J. Konturek, “Epidermal Growth Factor and Prostaglandin E(2) Accelerate Mucosal Recovery from Stress-Induced Gastric Lesions via Inhibition of Apoptosis,” Journal of Physiology-Paris, Vol. 95, No. 1-6, 2001, pp. 361-367.
[7] N. Kalia, K. D. Bardhan, M. W. Reed, S. Jacob and N. J. Brown, “Mast Cell Stabilization Prevents Ethanol-Induced Rat Gastric Mucosal Injury: Mechanisms of Protection,” Journal of Gastroenterology and Hepatology, Vol. 15, No. 2, 2000, pp. 133-141. doi:10.1046/j.1440-1746.2000.02064.x
[8] K. Kohda, K. Tanaka, Y. Aiba, M. Yasuda, T. Miwa and Y. Koga, “Role of Apoptosis Induced by Helicobacter Pylori Infection in the Development of Duodenal Ulcer,” Gut, Vol. 44, No. 4, 1999, pp. 456-462. doi:10.1136/gut.44.4.456
[9] W. A. Hoogerwerf and P. J. Pasricha, “Pharmacologic Therapy in Treating Achalasia,” Gastrointestinal Endoscopy Clinics of North America, Vol. 11, No. 2, 2001, pp. 311-324.
[10] D. C. Kim, S. H. Kim, B. H. Choi, N. I. Baek, D. Kim, M. J. Kim and K. T. Kim, “Curcuma Longa Extract Protects against Gastric Ulcers by Blocking H2 Histamine Receptors,” Biological & Pharmaceutical Bulletin, Vol. 28, No. 12, 2005, pp. 2220-2224. doi:10.1248/bpb.28.2220
[11] M. Tuorkey and K. Karolin, “Anti-ulcer Activity of Curcumin on Experimental Gastric Ulcer in Rats and Its Effect on Oxidative Stress/Antioxidant, IL-6 and Enzyme Activities,” Biomedical and Environmental Sciences, Vol. 22, No. 6, 2009, pp. 488-495. doi:10.1016/S0895-3988(10)60006-2
[12] P. Anand, S. G. Thomas, A. B. Kunnumakkara, C. Sundaram, K. B. Harikumar, B. Sung, S. T. Tharakan, K. Misra, I. K. Priyadarsini, K. N. Rajasekharan and B. B. Aggarwal, “Biological Activities of Curcumin and Its Analogues (Congeners) Made by Man and Mother Nature,” Biochemical Pharmacology, Vol. 76, No. 11, 2008, pp. 1590-1611. doi:10.1016/j.bcp.2008.08.008
[13] A. Salahuddin, A. Jeremy, J. Charles, Malemud and M. H. Tariq, “Biological Basis for the Use of Botanicals in Osteoarthritis and Rheumatoid Arthritis,” Evidence-Based Complementary and Alternative Medicine, Vol. 2, No. 3, 2005, pp. 301-308. doi:10.1093/ecam/neh117
[14] A. Vojdani and J. Erde, “Regulatory T Cells, a Potent Immunoregulatory Target for CAM Researchers: The Ultimate Antagonist (I),” Evidence-Based Complementary and Alternative Medicine, Vol. 3, No. 1, 2006, pp. 25-30. doi:10.1093/ecam/nek022
[15] Y. Abe, Hashimoto and S. T. Horie, “Curcumin Inhibition on Inflammatory Cytokine Production by Human Peripheral Blood Monocytes and Alveolar Macrophages,” Pharmaceutical Research, Vol. 39, No. 1, 1999, pp. 41-47. doi:10.1006/phrs.1998.0404
[16] S. Kapoor and K. I. Priyadarsini, “Protection of Radiation-Induced Protein Damage by Curcumin,” Biophysical Chemistry, Vol. 92, No. 1-2, 2001, pp. 119-126. doi:10.1016/S0301-4622(01)00188-0
[17] S. V. Jovanovic, C. W. Boone, S. Steenken, M. Trinoga and R. B. Kaskey, “How Curcumin Works Preferentially with Water Soluble Antioxidants,” Journal of the American Chemical Society, Vol. 123, No. 13, 2001, pp. 3064-3068. doi:10.1021/ja003823x
[18] L. R. Barclay, M. R. Vinqvist, K. Mukai, H. Goto, Y. Hashimoto, A. Tokunaga, H. UNo, “On the Antioxidant Mechanism of Curcumin: Classical Methods are Needed to Determine Antioxidant Mechanism and Activity,” Organic Letters, Vol. 2, No. 18, 2000, pp. 2841-2843. doi:10.1021/ol000173t
[19] K. I. Priyadarsini, D. K. Maity, G. H. Naik, M. S. Kumar, M. K. Unnikrishnan, J. G. Satav and H. Mohan, “Role of Phenolic O-H and Methylene Hydrogen on the Free Radical Reactions and Antioxidant Activity of Curcumin,” Free Radical Biology & Medicine, Vol. 35, No. 5, 2003, pp. 475-484. doi:10.1016/S0891-5849(03)00325-3
[20] M. C. Plucinsky, W. M. Riley, J. J. Prorok and J. A. Alhadeff, “Total and Lipid-Associated Serum Sialic Acid Levels in Cancer Patients with Different Primary Sites and Differing Degrees of Metastatic Involvement,” Cancer, Vol. 58, No. 12, 1986, pp. 2680-2685. doi:10.1002/1097-0142(19861215)58:12<2680::AID-CNCR2820581222>3.0.CO;2-L
[21] M. Harma, M. Harma and O. Erel, “Measurement of the Total Antioxidant Response in Preeclampsia with a Novel Automated Method,” European Journal of Obstetrics & Gynecology and Reproductive Biology, Vol. 118, No. 1, 2005, pp. 47-51. doi:10.1016/j.ejogrb.2004.04.012
[22] O. Erel, “A Novel Automated Method to Measure Total Antioxidant Response against Potent Free Radical Reactions,” Clinical Biochemistry, Vol. 37, No. 2, 2004, pp. 112-119. doi:10.1016/j.clinbiochem.2003.10.014
[23] T. Kurita-Ochiai, K. Fukushima and K. Ochiai, “Lipopolysaccharide Stimulates Butyric Acid-Induced Apoptosis in Human Peripheral Blood Mononuclear Cells,” Infection and Immunity, Vol. 67, No. 1, 1999, pp. 22-29.
[24] J. C. Becker, N. Grosser, C. Waltke, S. Schulz, K. Erdmann, W. Domschke, H. Schroder and T. Pohle, “Beyond Gastric Acid Reduction: Proton Pump Inhibitors Induce Heme Oxygenase-1 in Gastric and Endothelial Cells,” Biochemical and Biophysical Research Communications, Vol. 345, No. 3, 2006, pp. 1014-1021. doi:10.1016/j.bbrc.2006.04.170
[25] D. Lapenna and F. Cuccurullo, “Hypochlorous Acid and Its Pharmacological Antagonism: An Update Picture,” General Pharmacology, Vol. 27, No. 7, 1996, pp. 1145-1147. doi:10.1016/S0306-3623(96)00063-8
[26] W. A. Simon, E. Sturm, H. J. Hartmann and U. Weser, “Hydroxyl Radical Scavenging Reactivity of Proton Pump Inhibitors,” Biochemical Pharmacology, Vol. 71, No. 9, 2006, pp. 1337-1341. doi:10.1016/j.bcp.2006.01.009
[27] D. Das, D. Bandyopadhyay, M. Bhattacharjee, R. K. Banerjee, “Hydroxyl Radical Is the Major Causative Factor in Stress-Induced Gastric Ulceration,” Free Radical Biology & Medicine, Vol. 23, No. 1, 1997, pp. 8-18. doi:10.1016/S0891-5849(96)00547-3
[28] R. S. Devi, S. Narayan, G. Vani and C. S. Shyamala Devi, “Gastroprotective Effect of Terminalia Arjuna Bark on Diclofenac Sodium Induced Gastric Ulcer,” Chemico-Biological Interactions, Vol. 167, No. 1, 2007, pp. 71-83. doi:10.1016/j.cbi.2007.01.011
[29] J. L. Wallace, “Recent Advances in Gastric Ulcer Therapeutics,” Current Opinion in Pharmacology, Vol. 5, No. 6, 2005, pp. 573-577. doi:10.1016/j.coph.2005.06.004
[30] L. Laine, K. Takeuchi and A. Tarnawski, “Gastric Mucosal Defense and Cytoprotection: Bench to Bedside,” Gastroenterology, Vol. 135, No. 1, 2008, pp. 41-60. doi:10.1053/j.gastro.2008.05.030
[31] K. Sairam, S. Priyambada, N. C. Aryya and R. K. Goel, “Gastroduodenal Ulcer Protective Activity of Asparagus Racemosus: An Experimental, Biochemical and Histological Study,” Journal of Ethnopharmacology, Vol. 86, No. 1, 2003, pp. 1-10. doi:10.1016/S0378-8741(02)00342-2
[32] Y. Higuchi, “Chromosomal DNA Fragmentation in Apoptosis and Necrosis Induced by Oxidative Stress,” Biochemical Pharmacology, Vol. 66, No. 8, 2003, pp. 1527-1535. doi:10.1016/S0006-2952(03)00508-2
[33] M. J. Tuorkey and K. K. Bdul-Aziz, “A Pioneer Study on the Anti-ulcer Activities of Copper Nicotinate Complex [CuCl(HNA)2] in Experimental Gastric Ulcer Induced by Aspirin-Pylorus [corrected] Ligation Model (Shay Model),” Biomedicine & Pharmacotherapy, Vol. 63, No. 3, 2009, pp. 194-201. doi:10.1016/j.biopha.2008.01.015
[34] K. Mukhopadhyaya, D. Bhattacharya, A. Chakraborty, R. K. Goel and A. K. Sanyal, “Effect of Banana Powder (Musa sapientum var. paradisiaca) on Gastric Mucosal Shedding,” Journal of Ethnopharmacology, Vol. 21, No. 1, 1987, pp. 11-19. doi:10.1016/0378-8741(87)90089-4
[35] A. K. Sanyal, P. K. Mitra and R. K. Goel, “A Modified Method to Estimate Dissolved Mucosubstances in Gastric Juice,” Indian Journal of Experimental Biology, Vol. 21, No. 2, 1983, pp. 78-80.
[36] Y. Erbil, U. Turkoglu, U. Barbaros, E. Balik, V. Olgac, H. Kaya and B. Cimsit, “Oxidative Damage in an Experimentally Induced Gastric and Gastroduodenal Reflux Model,” Surgical Innovation, Vol. 12, No. 3, 2005, pp. 219-225. doi:10.1177/155335060501200306
[37] F. S. Lehmann and G. A. Stalder, “Hypotheses on the Role of Cytokines in Peptic Ulcer Disease,” European Journal of Clinical Investigation, Vol. 28, No. 7, 1998, pp. 511-519. doi:10.1046/j.1365-2362.1998.00306.x
[38] J. E. Crabtree, T. M. Shallcross, R. V. Heatley and J. I. Wyatt, “Mucosal Tumour Necrosis Factor Alpha and Interleukin-6 in Patients with Helicobacter Pylori Associated Gastritis,” Gut, Vol. 32, No. 12, 1991, pp. 1473-1477. doi:10.1136/gut.32.12.1473
[39] G. Sathyanarayan, P. K. Garg, H. Prasad and R. K. Tandon, “Elevated Level of Interleukin-6 Predicts Organ Failure and Severe Disease in Patients with Acute Pancreatitis,” Journal of Gastroenterology and Hepatology, Vol. 22, No. 4, 2007, pp. 550-554. doi:10.1111/j.1440-1746.2006.04752.x
[40] M. K. Jones, H. Kawanaka, D. Baatar, I. L. Szabo, K. Tsugawa, R. Pai, G. Y. Koh, I. Kim, I. J. Sarfeh and A. S. Tarnawski, “Gene Therapy for Gastric Ulcers with Single Local Injection of Naked DNA Encoding VEGF and Angiopoietin-1,” Gastroenterology, Vol. 121, No. 5, 2001, pp. 1040-1047. doi:10.1053/gast.2001.29308
[41] S. Szabo, A. Vincze, Z. Sandor, M. Jadus, Z. Gombos, A. Pedram, E. Levin, J. Hagar and G. Iaquinto, “Vascular Approach to Gastroduodenal Ulceration: New Studies with Endothelins and VEGF,” Digestive Diseases and Sciences, Vol. 43, No. 9, 1998, pp. 40S-45S.
[42] S. Szabo, T. Khomenko, Z. Gombos, X. M. Deng, M. R. Jadus and M. Yoshida, “Review Article: Transcription Factors and Growth Factors in Ulcer Healing,” Alimentary Pharmacology & Therapeutics, Vol. 14, Supplement 1, 2000, pp. 33-43. doi:10.1046/j.1365-2036.2000.014s1033.x
[43] M. Takahashi, T. Kawabe, K. Ogura, S. Maeda, Y. Mikami, N. Kaneko, A. TeraNo and M. Omata, “Expression of Vascular Endothelial Growth Factor at the Human Gastric Ulcer Margin and in Cultured Gastric Fibroblasts: A New Angiogenic Factor for Gastric Ulcer Healing,” Biochemical and Biophysical Research Communications, Vol. 234, No. 2, 1997, pp. 493-498. doi:10.1006/bbrc.1997.5974
[44] J. Wozniak-Holecka, J. Josko, M. Tyrpien, J. Kasperczyk, K. Steplewska and T. Holecki, “Influence of Vascular Endothelial Growth Factor (VEGF) on Gastroprotection in Stress-Induced Gastric Mucosal Ulcers in Rats,” Methods & Findings in Experimental & Clinical Pharmacology, Vol. 31, No. 8, 2009, pp. 523-531.
[45] T. Tanigawa, T. Watanabe, K. Otani, Y. Nadatani, H. Machida, H. Okazaki, H. Yamagami, K. Watanabe, K. Tominaga, Y. Fujiwara, N. Oshitani, K. Higuchi and T. Arakawa, “Leptin Promotes Gastric Ulcer Healing via Upregulation of Vascular Endothelial Growth Factor,” Digestion, Vol. 81, No. 2, 2010, pp. 86-95. doi:10.1159/000243719
[46] S. Milani and A. Calabro, “Role of Growth Factors and Their Receptors in Gastric Ulcer Healing,” Microscopy Research and Technique, Vol. 53, No. 5, 2001, pp. 360-371.

comments powered by Disqus

Copyright © 2017 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.