Role of Calcium in Glucagon Secretion

Abstract

The role of calcium ions in the process by which nutrients affect glucagon secretion by pancreatic islet α-cells remains the matter of an apparently endless debate. In the prolongation of recent articles dealing with this matter, the present review draws attention to the dual role of Ca2+ as revealed by prior publications. In such a perspective, emphasis is placed on the increase in glucagon output in response to the omission of extracellular Ca2+ as recorded in the presence of D-glucose or 2-ketoisocaproate, the permissive role of extracellular Ca2+ in the positive secretory response to arginine or a mixture of fumarate, glutamate and pyruvate, and the effects of an organic calcium-antagonist on glucagon output. Considering the role currently ascribed to Ca2+ in the activation of motile events involved in stimulus-secretion coupling, attention is also given to the effects of cytochalasin B, D2O and mitotic-spindle inhibitors upon the secretory response of α-cells exposed to D-glucose in the absence or presence of arginine.

Share and Cite:

Malaisse, W. (2014) Role of Calcium in Glucagon Secretion. Advances in Biological Chemistry, 4, 191-196. doi: 10.4236/abc.2014.43023.

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1] Vireira, E., Salehi, A. and Gylfe, E. (2007) Glucose Inhibits Glucagon Secretion by a Direct Effect on Mouse Pancreatic Alpha Cells. Diabetologia, 50, 370-379.
http://dx.doi.org/10.1007/s00125-006-0511-1
[2] Cheng-Xue, R., Gómez-Ruiz, A., Antoine, N., Noël, L.A., Chae, H.-Y., Ravier, M.A., Chimienti, F., Schuit, F.C. and Gilon, P. (2013) Tolbutamide Controls Glucagon Release from Mouse Islets Differently than Glucose. Involvement of KATP Channels from Both α-Cells and α-Cells. Diabetes, 62, 1612-1622.
http://dx.doi.org/10.2337/db12-0347
[3] Gylfe, E. (2013) Glucose Control of Glucagon Secretion: There Is More to It than KATP Channels. Diabetes, 62, 1391-1393.
http://dx.doi.org/10.2337/db13-0193
[4] Leclercq-Meyer, V., Marchand, J. and Malaisse, W.J. (1973) The Effect of Calcium and Magnesium on Glucagon Secretion. Endocrinology, 93, 1360-1370.
http://dx.doi.org/10.1210/endo-93-6-1360
[5] Leclercq-Meyer, V., Rebolledo, O., Marchand, J. and Malaisse, W.J. (1975) Glucagon Release: Paradoxical Stimulation by Glucose during Calcium Deprivation. Science, 189, 897-899.
http://dx.doi.org/10.1126/science.1098149
[6] Leclercq-Meyer, V., Marchand, J. and Malaisse, W.J. (1976) The Role of Calcium in Glucagon Release. Interactions between Glucose and Calcium. Diabetologia, 12, 531-538.
http://dx.doi.org/10.1007/BF01219520
[7] Leclercq-Meyer, V., Marchand, J. and Malaisse, W.J. (1977) An Arginine-Like Effect of the “Fumarate + Glutamate + Pyruvate” Mixture on Glucagon Release. Life Sciences, 20, 1193-1198.
http://dx.doi.org/10.1016/0024-3205(77)90492-1
[8] Leclercq-Meyer, V., Marchand, J. and Malaisse, W.J. (1976) The Role of Calcium in Glucagon Release. Interactions between Arginine and Calcium. Hormone Research, 7, 348-362.
http://dx.doi.org/10.1159/000178749
[9] Leclercq-Meyer, V., Marchand, J. and Malaisse, W.J. (1978) The Role of Calcium in Glucagon Release. Studies with Verapamil. Diabetes, 27, 996-1004.
http://dx.doi.org/10.2337/diab.27.10.996
[10] Leclercq-Meyer, V., Marchand, J. and Malaisse, W.J. (1979)Calcium dependency of glucagon release: its modulation by nutritional factors. American Journal of Physiology,236, E98-E104.
[11] Leclercq-Meyer, V., Marchand, J., Leclercq, R. and Malaisse, W.J. (1979) Interactions of α-Ketoisocaproate, Glucose and Arginine in the Secretion of Glucagon and Insulin from the Perfused Rat Pancreas. Diabetologia, 17, 121-126.
http://dx.doi.org/10.1007/BF01222213
[12] Leclercq-Meyer, V., Marchand, J., Leclercq, R. and Malaisse, W.J. (1981) Calcium Deprivation Enhances Glucagon Release in the Presence of 2-Ketoisocaproate. Endocrinology, 108, 2093-2097.
http://dx.doi.org/10.1210/endo-108-6-2093
[13] Leclercq-Meyer, V., Marchand, J. and Malaisse, W.J. (1983) Effect of K+ Deprivation and Ouabain upon Glucagon Release. Endocrinology, 113, 178-183.
http://dx.doi.org/10.1210/endo-113-1-178
[14] Leclercq-Meyer, V., Marchand, J. and Malaisse, W.J. (1974) Possible Role of a Microtubular-Microfilamentous System in Glucagon Secretion. Diabetologia, 10, 215-224.
http://dx.doi.org/10.1007/BF00423038
[15] Jijakli, H., Zhang, H.-X., Dura, E., Ramirez, R., Sener, A. and Malaisse, W.J. (2002) Effects of Cytochalasin B and D upon Insulin Release and Pancreatic Islet Cell Metabolism. International Journal of Molecular Medicine, 9, 165-172.
[16] Ravazzola, M., Malaisse-Lagae, F., Amherdt, M., Perrelet, A., Malaisse, W.J. and Orci, L. (1976) Patterns of Calcium Localization in Pancreatic Endocrine Cells. Journal of Cell Science, 27, 107-117.
[17] Malaisse, W.J. (2014) Paracrine Control of Glucagon Release by Somatostatin. International Journal of Molecular Medicine, 33, 491-498.
[18] Karimian, N., Qin, T., Liang, T., Osundiji, M., Huang, Y., Teich, T., Riddell, M.C., Cattral, M.S., Coy, D.H., Vranic, M. and Gaisano, H.Y. (2013) Somatostatin Receptor Type 2 Antagonism Improves Glucagon Counterregulation in Biobreeding Diabetic Rats. Diabetes, 62, 2968-2977.
http://dx.doi.org/10.2337/db13-0164

Copyright © 2024 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.