[1]
|
Fund WCR. http://wwwwcrf-ukorg/research/cancer_statistics/world_cancer_statistics
|
[2]
|
China’s Cancer Crisis. http://wwwchinaorgcn/2013-04/16/content_28556502htm
|
[3]
|
Parkin, D.M., Bray, F., Ferlay, J. and Pisani, P. (2001) Estimating the World Cancer Burden: Globocan 2000. International Journal of Cancer, 94, 153-156. http://dx.doi.org/10.1002/ijc.1440
|
[4]
|
Jemal, A., Siegel, R., Xu, J. and Ward, E. (2010) Cancer Statistics. A Cancer Journal for Clinicians, 60, 277-300. http://dx.doi.org/10.3322/caac.20073
|
[5]
|
Matthaios, D., Zarogoulidis, P., Balgouranidou, I., Chatzaki, E. and Kakolyris, S. (2011) Molecular Pathogenesis of Pancreatic Cancer and Clinical Perspectives. Oncology, 81, 259-272. http://dx.doi.org/10.1159/000334449
|
[6]
|
Li, X., Wang, H. and Jiang, Y. (1995) Establishment of a Human Pancreatic Adenocarcinoma Cell Line (Jf305) with p53 Expression. Chinese Journal of Cancer Research, 7, 251-254. http://dx.doi.org/10.1007/BF02672786
|
[7]
|
Murai, J., Huang, S.Y., Dar, B.B., Renaud, A., Zhang, Y., Doroshow, J.H., Ji, J., Takeda, S. and Pommier, Y. (2012) Trapping of PAPR1 and PARP2 by Clinical Parp Inhibitors. Cancer Research, 72, 5588-5599. http://dx.doi.org/10.1158/0008-5472.CAN-12-2753
|
[8]
|
Georges, N., Nicole, G.I., Marie, F., Frederique, M.C. and Vicent, F. (2003) Poly (ADP-Ribose) Polymerase (Parp-1) Is Not Involved in DNA Double Strand Break Recovery. BMC Cell Biology, 4, 7. http://dx.doi.org/10.1186/1471-2121-4-7
|
[9]
|
Wang, X.Z. and Weaver, D.T. (2011) The Ups and Downs of DNA Repair Biomarkers for PARP Inhibitor Therapies. American Journal of Cancer Research, 1, 301-327.
|
[10]
|
Henderson, B.R. (2012) The BRCA1 Breast Cancer Suppressor: Regulation of Transport, Dynamics, and Function at Multiple Subcellular Locations. Scientifica, Article ID 796808. http://dx.doi.org/10.6064/2012/796808
|
[11]
|
Hall, J.M, Lee, M.K., Newman, B., Morrow, J.E., Anderson, L.A., Huey, B. and King, M.C. (1990) Linkage of Early-Onset Familial Breast Cancer to Chromosome 17q21. Science, 250, 1684-1689. http://dx.doi.org/10.1126/science.2270482
|
[12]
|
Hofmann, W. and Schlag, P.M. (2000) BRCA1 and BRCA2—Breast Cancer Susceptibility Genes. Journal of Cancer Research and Clinical Oncology, 126, 487-496. http://dx.doi.org/10.1007/s004320000140
|
[13]
|
Carter, R.F. (2001) BRCA1, BRCA2 and Breast Cancer: A Concise Clinical Review. Clinical Investigation Medicine, 24, 147-157.
|
[14]
|
Satagopan, J.M., Offit, K., Foulkes, W., Robson, M.E., Wacholder, S., Eng, C.M., Karp, S.E. and Begg, C.B. (2001) The Lifetime Risks of Breast Cancer in Ashkenazi Jewish Carriers of BRCA1 and BRCA2 Mutations. Cancer Epide-Miology, Biomarkers &Prevention, 10, 467-473.
|
[15]
|
Peto, J., Collins, N., Barfoot, R., Seal, S., Warren, W., Rahman, N., Easton, D.F., Evans. C., Deacon, J. and Stratton, M.R. (1999) Prevalence of BRCA1 and BRCA2 Gene Mutations in Patients with Early-Onset Breast Cancer. Journal of National Cancer Institute, 91, 943-949. http://dx.doi.org/10.1093/jnci/91.11.943
|
[16]
|
http://www.ncbi.nlm.nih.gov/nuccore/U14680.1
|
[17]
|
http://www.ncbi.nlm.nih.gov/nuccore/U43746.1
|
[18]
|
Smith, T.M., Szabo, L.M., Jerome, C. I., McEuen, N., Taylor, M., Hood, M.L. and King, M.C. (1996) Complete Genomic Sequence and Analysis of 117 kb of Human DNA Containing the Gene BRCA1. Genome Research, 6, 1029-1049. http://dx.doi.org/10.1101/gr.6.11.1029
|
[19]
|
Wooster, R., Neuhausen,S.L., Mangion, J., Quirk, Y., Ford, D., Collins, N., Nguyen, K., Seal, S., Tran, T., Averill, D., et al. (1994) Localization of a Breast Cancer Susceptibility Gene, BRCA2, to Chromosome 13q12-13. Science, 265, 2088-2090. http://dx.doi.org/10.1126/science.8091231
|
[20]
|
Garvin, A.M., Attenhofer-Haner, M. and Scott, R.J. (1997) BRCA1 and BRCA2 Mutation Analysis in 86 Early Onset Breast/Ovarian Cancer Patients. Journal of Medical Genetics, 34, 990-995. http://dx.doi.org/10.1136/jmg.34.12.990
|
[21]
|
Christine, S., Jean-Paul, M., Claire, J.R., François, E., Dominique, S.L., Brigitte, B.P. and Hagay, S. (2002) Testing for BRCA1 Mutations: A Cost-Effectiveness Analysis. European Journal of Human Genetics, 10, 599-606. http://dx.doi.org/10.1038/sj.ejhg.5200854
|
[22]
|
Antoni, L., Sodha, N., Collins, I. and Garrett, M.D. (2007) CHK2 Kinase: Cancer Susceptibility and Cancer Therapy— Two Sides of the Same Coin? Nature Review Cancer, 7, 925-936. http://dx.doi.org/10.1038/nrc2251
|
[23]
|
Bayram, S., Akkiz, H. and Topaktas, M. (2013) CHK2 1100delC, IVS2+1G>A and I157T Mutations Are Not Present in Hepatocellular Cancer Cases from a Turkish Population. Gene, 512, 232-236. http://dx.doi.org/10.1016/j.gene.2012.10.045
|
[24]
|
Ahn, J., Urist, M. and Prives, C. (2004) The Chk2 Protein Kinase. DNA Repair (Amst.), 3, 1039-1047. http://dx.doi.org/10.1016/j.dnarep.2004.03.033
|
[25]
|
Bell, D.W., Varley, J.M., Szydlo, T.E., Kang, D.H., Wahrer, D.C., Shannon, K.E., Lubratovich, M.S., Verselis, J., Isselbacher, K.J., Fraumeni, J.F., Birch, J.M., Li, F.P., Garber, J.E. and Haber, D.A. (1999) Heterozygous Germ Line hCHK2 Mutations in Li-Fraumeni Syndrome. Science, 286, 2528-2531. http://dx.doi.org/10.1126/science.286.5449.2528
|
[26]
|
Sodha, N., Williams, R., Mangion, J., Bullock, S.L., Yuille, M.R. and Eeles, R.A. (2000) Screening hCHK2 for Mutations. Science, 289, 359.
|
[27]
|
Shaag, A., Walsh, T., Renbaum, P., Kirchhoff, T., Nafa, K., Shiovitz, S., Mandell, J.B., Welcsh, P., Lee, M.K., Ellis, N., Offit, K., Levy-Lahad, E. and King, M.C. (2005) Functional and Genomic Approaches Reveal an Ancient CHEK2 Allele Associated with Breast Cancer in the Ashkenazi Jewish Population. Human Molecular Genetics, 14, 555-563. http://dx.doi.org/10.1093/hmg/ddi052
|
[28]
|
Cybulski, C., Gorski, B., Huzarski, T., Masojc, B., Mierzejewski, M., Debniak, T., et al. (2004) CHEK2 Is a Multiorgan Cancer Susceptibility Gene. The American Journal of Human Genetics, 75, 1131-1135. http://dx.doi.org/10.1086/426403
|
[29]
|
Cybulski, C., Huzarski, T., Górski, B., Masojc, B., Mierzejewski, M., Debniak, T., Gliniewicz, B., Matyjasik, J., Zlowocka, E., Kurzawski, G., Sikorski, A., Posmyk, M., Szwiec, M., Czajka, R., Narod, S.A. and Lubiński, J. (2004) A Novel Founder CHEK2 Mutation Is Associated with Increased Prostate Cancer Risk. Cancer Research, 64, 2677-2679. http://dx.doi.org/10.1158/0008-5472.CAN-04-0341
|
[30]
|
Cybulski, C., Wokolorczyk, D., Huzarski, T., Byrski, T., Gronwald, J., Górski, B., Debniak, T., Masojc, B., Jakubowska, A., Gliniewicz, B., Sikorski, A., Stawicka, M., Godlewski, D., Kwias, Z., Antczak, A., Krajka, K., Lauer, W., Sosnowski, M., Sikorska-Radek, P., Bar, B., Klijer, R., Zdrojowy, R., Malkiewicz, B., Borkowski, A., Borkowski, T., Szwiec, M., Narod, S.A. and Lubiński, J. (2006) A Large Germline Deletion in the Chek2 Kinase Gene Is Associated with an Increased Risk of Prostate Cancer. Journal of Medical Genetics, 43, 863-866. http://dx.doi.org/10.1136/jmg.2006.044974
|
[31]
|
Meijers-Heijboer, H., Van den, A., Klijn, M., Wasielewski, J., de Snoo., A., Oldenburg, R., Hollestelle, A., Houben, M., Crepin, E., van Veghel-Plandsoen, M., Elstrodt, F., van Duijn, C., Bartels, C., Meijers, C., Schutte, M., McGuffog, L., Thompson, D., Easton, D., Sodha, N., Seal, S., Barfoot, R., Mangion, J., Chang-Claude, J., Eccles, D., Eeles, R., Evans, D.G., Houlston, R., Murday, V., Narod, S., Peretz, T., Peto, J., Phelan, C., Zhang, H.X., Szabo, C., Devilee, P., Goldgar, D., Futreal, P.A., Nathanson, K.L., Weber, B., Rahman, N. and Stratton, M.R. (2002) Low-Penetrance Susceptibility to Breast Cancer Due to CHEK2(*)1100delC in Noncarriers of BRCA1 or BRCA2 Mutations. Nature Genetics, 31, 55-59. http://dx.doi.org/10.1038/ng879
|
[32]
|
Dong, X.Y., Wang, L., Ken, T., Wang, X.S., Julie, M., Cunningham, M., McDonnell, S.K., Chiping, Q., Angela, F., Marks, S., Susan, L.S., Peterson, B.J., Smith, D.I., Cheville, J.C., Blute, M.L., Jacobsen, S.J., Schaid, D.J., Tindall, D.J., Thibodeau, S.N. and Liu, W. (2003) Mutations in CHEK2 Associated with Prostate Cancer Risk. The American Journal of Human Genetics, 72, 270-280. http://dx.doi.org/10.1086/346094
|
[33]
|
Kleibl, Z., Havranek, O., Novotny, J., Kleiblova, P., Soucek, P. and Pohlreich, P. (2008) Analysis of CHEK2 FHA Domain in Czech Patients with Sporadic Breast Cancer Revealed Distinct Rare Genetic Alterations. Breast Cancer Research and Treatment, 112, 159-164. http://dx.doi.org/10.1007/s10549-007-9838-7
|
[34]
|
Cybulski, C., Górski, B., Huzarski, T., Masojc, B., Mierzejewski, M., Debniak, T., Teodorczyk, U., Byrski, T., Gronwald, J., Matyjasik, J., Zlowocka, E., Lenner, M., Grabowska, E., Nej, K., Castaneda, J., Medrek, K., Szymańska, A., Szymańska, J., Kurzawski, G., Suchy, J., Oszurek, O., Witek, A., Narod, S.A. and Lubiński, J. (2004) CHEK2 Is a Multiorgan Cancer Susceptibility Gene. The American Journal of Human Genetics, 75, 1131-1135. http://dx.doi.org/10.1086/426403
|
[35]
|
Matsuoka, S., Nakagawa, T., Masuda, A., Haruki, N., Elledge, S.J. and Takahashi, T. (2001) Reduced Expression and Impaired Kinase Activity of a Chk2 Mutant Identified in Human Lung Cancer. Cancer Research, 61, 5362-5365.
|
[36]
|
Sodha, N., Richard, S.H., Richard, W., Martin, A.Y., John, M. and Rosalind, A.E. (2002) A Robust Method for Detecting CHK2/RAD53 Mutations in Genomic DNA. Humanmutation, 19, 173-177. http://dx.doi.org/10.1002/humu.10031
|
[37]
|
Djureinovic, T., Lindblom, A., Dalén, J., Dedorson, S., Edler, D., Hjern, F., Holm, J., Lenander, C., Lindforss, U., Lundqvist, N., Olivecrona, H., Olsson, L., Påhlman, L., Rutegård, J., Smedh, K., Törnqvist, A., Eiberg, H. and Bisgaard, M.L. (2006) The CHEK2 1100delC Variant in Swedish Colorectal Cancer. Anticancer Research, 26, 4885-4888.
|
[38]
|
Bayram, S., Akkiz, H. and Topaktas, M. (2013) CHK2 1100delC, IVS2+1G>A and I157T Mutations Are Not Present in Hepatocellular Cancer Cases from a Turkish Population. Gene, 512, 232-236. http://dx.doi.org/10.1016/j.gene.2012.10.045
|
[39]
|
Garvin, A.M. (1998) A Complete Protein Truncation Test for BRCA1 and BRCA2. European Journal of Human Genetics, 6, 226-234. http://dx.doi.org/10.1038/sj.ejhg.5200172
|
[40]
|
Ottini, L., D’Amico, C., Noviello, C., Lauro, S., Lalle, M., Fornarini, G., Colantuoni, O.A., Pizzi, C., Cortesi, E., Carlini, S., Guadagni, F., Bianco, A.R., Frati, L., Contegiacomo, A. and Mariani-Costantini, R. (2000) BRCA1 and BRCA2 Mutations in Central and Southern Italian Patients. Breast Cancer Reserch, 22, 307-310. http://dx.doi.org/10.1186/bcr72
|
[41]
|
Cybulski, C., Górski, B., Huzarski, T., Masojc, B., Mierzejewski, M., Debniak, T., Teodorczyk, U., Byrski, T., Gronwald, J., Matyjasik, J., Zlowocka, E., Lenner, M., Grabowska, E., Nej, K., Castaneda, J., Medrek, K., Szymańska, A., Szymańska, J., Kurzawski, G., Suchy, J., Oszurek, O., Witek, A., Narod, S.A. and Lubiński, J. ( 2004) CHEK2 Is a Multiorgan Cancer Susceptibility Gene. The American Journal of Human Genetics, 75, 1131-1135. http://dx.doi.org/10.1086/426403
|