ABC> Vol.3 No.6, December 2013

Synthesis of C-8 alkyl xanthines by pentaamminecobalt(III) complex

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ABSTRACT

Alkyl xanthines underwent selective homolytic aromatic substitution at C-8 position with alkyl groups of pentaamminecobalt(III) complex. In this process of synthesis, we used monoalkyl hydrazines as the radical source in aqueous ammonia solution. Evidence supporting coordination of the alkyl hydrazine to pentaamminecobalt(III) complex by radical trapping was in good agreement with literature. The products were characterized using GC-MS and 1H, 14N and 59Co NMR spectroscopy.

 

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Suravajhala, R. (2013) Synthesis of C-8 alkyl xanthines by pentaamminecobalt(III) complex. Advances in Biological Chemistry, 3, 521-524. doi: 10.4236/abc.2013.36058.

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