Relationship between acute high altitude response, cardiac function injury, and high altitude de-adaptation response after returning to lower altitude*
Shengyue Yang, Qiquan Zhou, Zifu Shi, Enzhi Feng, Ziqiang Yan, Zhongxin Tian, He Yin, Yong Fan
Center of Respiratory Medicine, The 4th Hospital, Lanzhou Command, PLA, Xining, China.
Department of High Altitude Diseases, College of High Altitude Military Medicine, Third Military Medical University, Chongqing, China; Key Laboratory of High Altitude Medicine of Ministry of Education and Key Laboratory of High Altitude Medicine of PLA, Chongqing, China.
Department of High Altitude Diseases, College of High Altitude Military Medicine, Third Military Medical University, Chongqing, China;Key Laboratory of High Altitude Medicine of Ministry of Education and Key Laboratory of High Altitude Medicine of PLA, Chongqing, China.
The 68303 Troop Hospital of People’s Liberation Army, Wuwei, China.
DOI: 10.4236/odem.2013.11002   PDF    HTML     4,240 Downloads   9,798 Views   Citations

Abstract

The relationship between acute high altitude response (AHAR), cardiac function injury, and high altitude de-adaptation response (HADAR) was assessed. Cardiac function indicators were assessed for 96 men (18 - 35 years old) deployed into a high altitude (3700 - 4800 m) environment requiring intense physical activity. The subjects were divided into 3 groups based on AHAR at high altitude: severe AHAR (n = 24), mild to moderate AHAR (Group B, n = 47) and non-AHAR (Group C, 25); and based on HADAR: severe HADAR (Group E, n = 19), mild to moderate HADAR (Group F, n = 40) and non-HADAR (Group G, n = 37) after return to lower altitude (1,500 m). Cardiac function indicators were measured after 50 days at high altitude and at 12 h, 15 days, and 30 days after return to lower altitude. Controls were 50 healthy volunteers (Group D, n = 50) at 1500 m. Significant differences were observed in cardiac function indicators among groups A, B, C, and D. AHAR score was positively correlated with HADAR score (r = 0.863, P < 0.001). Significant differ- ences were also observed in cardiac function indicators among groups D, E, F, and G, 12 h and15 days after return to lower altitude. There were no significant differences in cardiac function indicators among the groups, 30 days after return to lower altitude, compared to group D. The results indicated that the severity of HADAR is associated with the severity of AHAR and cardiac injury, and prolonged recovery.

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Yang, S. , Zhou, Q. , Shi, Z. , Feng, E. , Yan, Z. , Tian, Z. , Yin, H. and Fan, Y. (2013) Relationship between acute high altitude response, cardiac function injury, and high altitude de-adaptation response after returning to lower altitude*. Occupational Diseases and Environmental Medicine, 1, 4-10. doi: 10.4236/odem.2013.11002.

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1] Fan, Y. and Zhou, Q. (2012) Research progress of de- adaptation to high altitude. Journal of Preventive Medicine of Chinese People’s Liberation Army, 30, 227-230.
[2] He, B., Wang, J., Qian, G., Hu, M., Qu, X., Wei, Z., Li, J., Chen, Y., Chen, H., Zhou, Q. and Wang, G. (2013) Analysis of high-altitude de-acclimatization syndrome after exposure to high altitudes: A cluster-randomized controlled trial. PLoS One, 8, e62072. http://dx.doi.org/10.1371/journal.pone.0062072
[3] Zhou, Q.Q., Yang, S.Y., Luo, Y.J., Qi, Y.S., Yan, Z.Q., Shi, Z.F. and Fan, Y. (2012) A randomly-controlled study on the cardiac function at the early stage of return to the plains after short-term exposure to high altitude. PLoS One, 7, e31097.
[4] Shi, Z., Zhou, Q., Xiang, L., Ma, S., Yan, C. and Luo, H. (2011) Three preparations of compound Chinese herbal medicines for de-adaptation to high altitude: A random- ized, placebo-controlled trial. Journal of Chinese Integra- tive Medicine, 9, 395-401. http://dx.doi.org/10.3736/jcim20110408
[5] Zhou, Q., Yang, S., Yuan, Z., Wang, Y., Zhang, X., Gao, W., Shi, Z., Yang, Y., Wu, Y., Fan, Y., Wang, G. and Gao, Y. (2012) A research in diagnostic criteria of high altitude de-adaptation for plateau migrants returning to the plains: a multicenter, randomized controlled trial. Medical Jour- nal of Chinese People’s Liberation Army, 37, 146-155.
[6] West, J.B. (2010) English translation of “Nomenclature, classification, and diagnostic criteria of high altitude disease in China”. High Altitude Medicine & Biology, 11, 169-172. http://dx.doi.org/10.1089/ham.2010.1014
[7] Simpson, J., Miller, O., Bell, A., Bellsham-Revell, H., McGhie, J. and Meijboom, F. (2012) Image orientation for three-dimensional echocardiography of congenital heart disease. The International Journal of Cardiovascu- lar Imaging, 28, 743-753. http://dx.doi.org/10.1007/s10554-011-9893-3
[8] Fakhri, A.A., Hughes-Doichev, R.A., Biederman, R.W. and Murali, S. (2012) Imaging in the evaluation of pul- monary artery hemodynamics and right ventricular struc- ture and function. Heart Failure Clinics, 8, 353-372. http://dx.doi.org/10.1016/j.hfc.2012.04.004
[9] Zhao, S., Deng, Y.B., Chen, X.L. and Liu, R. (2012) As- sessment of right ventricular function in recipient twin of twin to twin transfusion syndrome with speckle tracking echocardiography. Ultrasound in Medicine and Biology, 38, 1502-1507. http://dx.doi.org/10.1016/j.ultrasmedbio.2012.05.009
[10] Li, B., Liu, J. and Chen, L. (2005) Changes of adenylate content and distribution in myocardium and mitochondria of rats after hypoxic exposure. Medical Journal of National Defending Forces In Northwest China, 26, 90-92.
[11] Li, J. and Xing, L. (2012) The effects of simulated 3500 m different hypoxic training on free radical metabolism and respiratory chain function of mitochondrial in myo- cardium after exhaustive running in rat. Journal of Shanghai Physical Education Institute, 36, 51-55.
[12] Rozova, K.V. (2008) Effect of normo-and hypobaric hy- poxia on ultrastructure of the lung and myocardial tissue. Fiziolohichnyi Zhurnal, 54, 63-68.
[13] Zhao, Y. and Ao, H. (2011) Research progress of myocar- dial ischemia reperfusion injury. Chinese Circulation Journal, 26, 396-398.
[14] Kin, J.K., Pedram, A., Razandi, M. and Levin, E.R. (2006) Estrogen prevents cardiomyocyte apoptosis through inhi- bition of reactive oxygen species and differential regulation of p38 kinase isoforms. Journal of Biological Chemistry, 281, 6760-6767. http://dx.doi.org/10.1074/jbc.M511024200
[15] Zhang, K., Bai, Y., Song, T. and Zhang, G. (2013) In vivo and in vitro evidence of protective effects of a natural flavone on rat myocardial ischemia-reperfusion and hy- poxia-reoxygenation injuries. Journal of Cardiovascular Pharmacology and Therapeutics, 18, 31-36. http://dx.doi.org/10.1177/1074248412461713
[16] Feygin, J., Hu, Q., Swingen, C. and Zhang, J. (2008) Relationships between regional myocardial wall stress and bioenergetics in hearts with left ventricular hypertrophy. American Journal of Physiology: Heart and Circulatory Physiology, 294, H2313-H2321. http://dx.doi.org/10.1152/ajpheart.01288.2007
[17] Zhang, D.W., Bian, Z.P., Xu, J.D., Wu, H.F., Gu, C.R., Zhou, B., Chen, X.J. and Yang, D. (2012) Astragaloside IV alleviates hypoxia/reoxygenation-induced neonatal rat cardiomyocyte injury via the protein kinase A pathway. Pharmacology, 90, 95-101. http://dx.doi.org/10.1159/000339476
[18] Li, Q., Cui, N., Du, Y., Ma, H. and Zhang, Y. (2013) Anandamide reduces intracellular Ca2+ concentration through suppression of Na+/Ca2+ exchanger current in rat cardiac myocytes. PLoS One, 8, e63386. http://dx.doi.org/10.1371/journal.pone.0063386
[19] Hu, J., Wang, Q.J., Hu, Y.H. and Li, Y.F. (2012) A study of high-altitude hypoxia-induced cell stress in murine model. Cell Biochemistry and Biophysics, 64, 85-88. http://dx.doi.org/10.1007/s12013-012-9374-x

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