The Modification of Poly amidoamine (PAMAM-G0.5) by Cytosine

Omid Louie, Abdolhossien Massoudi, Hooshang Vahedi, Hajar Asadi, Sami Sajjadifar

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Chemistry Department, Payame Noor University, Mashhad, Iran.

DOI: 10.4236/eng.2012.410B026                

Abstract

The half generation Poly(amidoamine) (PAMAM) dendrimers was synthesized and characterized and modification by heterocyclic DNA base (Cytosine) . The conjugated Cytosine  modified detected by FT-IR, ¹H NMR, ¹³C NMR and Mass spectroscopy analysis.

Keywords

Component; Polyamidoamine; PAMAM; Cytosine

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1]	[1] S.M. Buck, Y.E.L Koo, E. Park, H. Xu, M.A. Philbert, M.A. Brasuel; R. Kopelman,. Optochemical nanosensor PEBBLEs: photonic explorers for bioanalysis with biologically localized embedding, Current Opinion in Chemical Biology 2004, 8, 540–546.
[2]	A.J. Haes, R.P. Van Duyne, Preliminary studies and potential applications of localized surface plasmon resonance spectroscopy in medical diagnostics, Expert Review of Molecular Diagnostics 2004, 4, 527–537.
[3]	J.L. West, N.J. Halas, Engineered nanomaterials for biophotonics applications: improving sensing, imaging, and therapeutics, Annual Review of Biomedical Engineering 2003, 5, 285–292.
[4]	J.M.J. Fréchet, D.A. Tomalia Dendrimers and Other Dendritic Polymers, John Wiley & Sons,West Sussex 2001
[5]	K.K. Ong, A.L. Jenkins; R. Chen, D.A. Tomalia, H.D. Durst, Dendrimer enhanced immunosensors for biological detection, Analytica Chimica Acta 2001, 444, 143–148.
[6]	C. Dufes, W.N. Keith, A. Bilsland, I. Proutski; J.F. Uchegbu; Schatzlein, A.G. Synthetic anticancer gene medicine exploits intrinsic antitumor activity of cationic vector to cure established tumors, Cancer Research 2005, 65, 8079–8084.
[7]	A. D’Emanuele, Attwood, D. Dendrimer-drug interactions, Advanced Drug Delivery Reviews 2005, 572, 147–2162.
[8]	Venditto, V.J.; Regino, C.A.S.; Brechbiel, M.W. PAMAM dendrimer based macromolecules as improved contrast agents, Molecular Pharmaceutics 2005, 2, 302–311.
[9]	A. H. Massoudi , H. Vahedi, O. Louie , S.Sajjadifar ; E – Journal of Chemistry 2009,Vol. 6(3)681-684.
[10]	D.A. Tomalia,Chem. Today 2005, 23,41.
[11]	W. Pei, Zh. Xin-Han, W. Zhi-Yu, M. Min, Li. Xu, N. Qian, Generation 4 polyamidoamine dendrimers is a novel candidate of nano-carrier for gene delivery agents in breast cancer treatment, Cancer Letters. 2010, 298, 34–49.
[12]	O.Louie, A.H. Massoudi, H. Vahedi, S.Sajjadifar, “Determination of molecular weight and molecular radius of the polyamido carboxylicacid dendrimer using generation numbers”, Polymer,2009, 50, 5605–5607
[13]	O. Louie et al, PAMAM Megamer (G2-G2)as a versatile in gene delivery , Clinical Biochemistry, Clinical Biochemistry, Volume 44, Issue 13, Supplement, September 2011, Page S281-S282
[14]	A.M. Massoudi,H. Vahedi, O. Louie, S. Sajjadifar, S. Damavandi, Der Chemica Sinica, 2011, 2 (4):312-315