Epidemiology of hodgkin’s lymphoma

Zahra Mozaheb

Hematology-Oncology Department, Imam-Reza Hospital, Mashhad University of Medical Science, Mashhad, Iran;.

DOI: 10.4236/health.2013.55A003                

Abstract

The epidemiology of Hodgkin’s Lymphoma (HL) varies with age at clinical onset. In developing countries, the disorder appears predominantly during childhood and its incidence decreases with age, while in industrialized countries, the incidence rate increase with age. There has long been a view that the differences in descriptive epidemiology of Hodgkin’s Lymphoma around the world, and also between children, young adults and older adults may reflect differences in etiology between them. Hodgkin’s Lymphoma has long been suspected to have an infectious precursor, and indirect evidence has implicated Epstein-Barr virus (EBV), as a causal agent. The etiology of EBV-negative cases remains obscure. Epidemiological investigation of the etiology of Hodgkin’s Lymphoma is making steady progress, and it leads to a better understanding and hence prevention. This review considers in detail the descriptive and the etiological epidemiology of Hodgkin’s Lymphoma.

Keywords

Hodgkin’s Lymphoma-Epidemiology-Etiology

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1]	Mirsadraee, S., Farzadnia, M., Heidary, F., Rahimi, M., Jabbari Noghabi, H. and Kakhki, S. (2011) A comparative immumohistochemical diagnosis of Hodgkin’s Lymphoma with conventional method.
[2]	Classical, H., Michael, C., Jame, A., Wyndham, H.W. and Elaine, S.J. (2009) Bethesda handbook of clinical hematology, Lippincott Williams & Wilkins, Philadelphia.
[3]	Mozaheb, Z. (2012) Epidemiology of lymphoid malignnancy in Asia epidemiology insights. Mashhad University of Medical Science, Mashhad.
[4]	Mozaheb, Z., Aledavood, A. and Farzad, F. (2011) Distributions of major sub-types of lymphoid malignancies among adults in Mashhad, Iran. Cancer Epidemiology, 35, 26-29. doi:10.1016/j.canep.2010.09.009.
[5]	Cartwright, R.A. and Watkins, G. (2004) Epidemiology Of hodgkin’s disease: A review. Hematological Oncology, 22, 11-26. doi:10.1002/hon.723
[6]	Flowers, C.R. and Armitage, J.O. (2010) A Decade of progress in lymphoma: advances and continuing challenges. Clinical Lymphoma Myeloma and Leukemia, 10, 414-423. doi:10.3816/CLML.2010.n.086.
[7]	Thomas, R., Re, D., Zander, T., Wolf, J. and Diehl, V. (2002) Epidemiology and etiology of Hodgkin’s lymphoma. Annals of oncology, 13, 147-152. doi:10.1093/annonc/mdf652.
[8]	Ries, L.A.G., Miler, B.A., Hankey, B.F. and Harras, A.E.B.K. (1994) SEER cancer statistics review, 1973-1991: Tables and graphs. National Institutes of Health, National Cancer Institute, Bethesda.
[9]	Swerdlow, A.J. (2003) Epidemiology of hodgkin’s disease and non-Hodgkin’s lymphoma. European Journal of Nuclear Medicine and Molecular Imaging, 30, S3-S12. doi:10.1007/s00259-003-1154-9
[10]	Pareen, S., Alison, M., Neha, M. and Christopher, R. (2011) Incidence patterns and outcomes for hodgkin lymphoma patients in the United States. Advances in Hematology, 2011, 725219.
[11]	Caporaso, N.E., Goldin, L.R., Anderson, W.F. and Landgren, O. (2009) Current insight on trends, causes, and mechanisms of Hodgkin’s lymphoma. The Cancer Journal, 15, 117-123. doi:10.1097/PPO.0b013e3181a39585.
[12]	Aozasa, K., Ueda, T., Tamai, M. and Tsujimura T. (1986) Hodgkin’s disease in Osaka, Japan (1964-1985). European Journal of Cancer and Clinical Oncology, 22, 11171119. doi:10.1016/0277-5379(86)90016-7
[13]	Glaser, S.L. and Hsu, J.L. (2002) Hodgkin’s disease in Asians: Incidence patterns and risk factors in population- based data. Leukemia Research, 26, 261-269. doi:10.1016/S0145-2126(01)00126-6.
[14]	Correa, P. and O’Conor, G.T. (1971) Epidemiologic patterns of Hodgkin’s disease. International Journal of Cancer, 8, 192-201. doi:10.1002/ijc.2910080203.
[15]	Spitz, M., Sider, J., Johnson, C., Butler, J., Pollack, E. and Newell, G. (1986) Ethnic patterns of Hodgkin’s disease incidence among children and adolescents in the United States, 1973-1982. Journal of the National Cancer Institute, 76, 235-239.
[16]	Glaser, S.L. and Jarrett, R.F. (1996) The epidemiology of Hodgkin’s disease. Baillière’s Clinical Haematology, 9, 401-416. doi:10.1016/S0950-3536(96)80018-7
[17]	Thomas, R.K., Re, D., Zander, T., Wolf, J. and Diehl, V. (2002) Epidemiology and etiology of Hodgkin’s lymphoma. Annals of Oncology, 13, 147-152. doi:10.1093/annonc/mdf652
[18]	Wolf, J. and Diehl, V. (1994) Is Hodgkin’s disease an infectious disease? Annals of Oncology, 5, S105-S111. doi:10.1093/annonc/5.suppl_1.S105.
[19]	Swerdlow, A.J. (2003) Epidemiology of Hodgkin’s disease and non-Hodgkin’s lymphoma. European Journal of Nuclear Medicine and Molecular Imaging, 30, S3-S12. doi:10.1007/s00259-003-1154-9.
[20]	Mueller, N., Evans, A., Harris, N.L., Comstock, G.W., Jellum, E., Magnus, K., et al., (1989) Hodgkin’s disease and Epstein-Barr virus. New England Journal of Medicine, 320, 689-695. doi:10.1056/NEJM198903163201103.
[21]	Ambinder, R.F. (2007) Epstein-Barr virus and Hodgkin Lymphoma. Hematology, 2007, 204-209. doi:10.1182/asheducation-2007.1.204
[22]	Hjalgrim, H., Askling J., Rostgaard, K., Hamilton-Dutoit, S., Frisch, M., Zhang, J.-S., et al., (2003) Characteristics of Hodgkin’s Lymphoma after infectious mononucleosis. New England Journal of Medicine, 349, 1324-1332. doi:10.1056/NEJMoa023141.
[23]	Sauce, D., Larsen, M., Leese, A., Millar, D., Khan, N., Hislop, A., et al., (2007) IL 7R versus CCR7 and CD45 as markers of virus specific CD8+ T cell differentiation: Contrasting pictures in blood and tonsillar lymphoid tissue. Journal of Infectious Diseases, 195, 268-278. doi:10.1086/510248.
[24]	Landgren, O. and Caporaso, N.E. (2007) New aspects in descriptive, etiologic, and molecular epidemiology of Hodgkin’s Lymphoma. Hematology/Oncology Clinics of North America, 21, 825-840. doi:10.1016/j.hoc.2007.07.001.
[25]	Hjalgrim, H., Ekström Smedby, K., Rostgaard, K., Molin, D., Hamilton-Dutoit, S., Chang, E.T., et al., (2007) Infectious mononucleosis, childhood social environment, and risk of Hodgkin lymphoma. Cancer research, 67, 2382. doi:10.1158/0008-5472.CAN-06-3566.
[26]	Glaser, S.L., Lin, R.J., Stewart, S.L., Ambinder, R.F., Jarrett, R.F., Brousset, P., et al., (1997) Epstein Barr virus associated Hodgkin’s disease: Epidemiologic characteristics in international data. International Journal of Cancer, 70, 375-382. doi:10.1002/(SICI)1097-0215(19970207)70:4<375::AID-IJC1>3.0.CO;2-T.
[27]	Zarate-Osorno, A., Roman, L.N., Kingma, D.W., Meneses-Garcia, A. and Jaffe, E.S. (1995) Hodgkin’s disease in Mexico. Prevalence of Epstein Barr virus sequences and correlations with histologic subtype. Cancer, 75, 13601366. doi:10.1002/1097-0142(19950315)75:6<1360::AID-CNCR2820750619>3.0.CO;2-U.
[28]	Brousset, P., Chittal, S., Schlaifer, D., Icart, J., Payen, C., Rigal-Huguet, F., et al., (1991) Detection of Epstein-Barr virus messenger RNA in Reed-Sternberg cells of Hodgkin’s disease by in situ hybridization with biotinylated probes on specially processed modified acetone methyl benzoate xylene (ModAMeX) sections [see comments]. Blood, 77, 1781.
[29]	Wilson, K., Freeland, J., Gallagher, A., Cosby, S., Earle, J., Alexander, F., et al. (2007) Measles virus and classical Hodgkin lymphoma: No evidence for a direct association. International Journal of Cancer, 121, 442-447. doi:10.1002/ijc.22629.
[30]	Mozaheb, Z., Aledavood, A. and Farzad, F. (2012) Diet and non-Hodgkin’s lymphoma risk. The Pan African Medical Journal, 12.
[31]	Glaser, S.L., Lin, R.J., Stewart, S.L., Ambinder, R.F., Jarrett, R.F., Brousset, P., et al. (1997) Epstein-Barr virus- associated Hodgkin’s disease: Epidemiologic characteristics in international data. International Journal of Cancer, 70, 375-382. doi:10.1002/(SICI)1097-0215(19970207)70:4<375::AID-IJC1>3.0.CO;2-T.
[32]	Hjalgrim, H., Ekström Smedby, K., Rostgaard, K., Molin, D., Hamilton-Dutoit, S., Chang, E.T., et al. (2007) Infectious mononucleosis, childhood social environment, and risk of Hodgkin lymphoma. Cancer Research, 67, 2382-2328. doi:10.1158/0008-5472.CAN-06-3566.
[33]	Flavell, K.J., Biddulph, J.P., Powell, J.E., Parkes, S.E., Redfern, D., Weinreb, M., et al. (2001) South Asian ethnicity and material deprivation increase the risk of Epstein-Barr virus infection in childhood Hodgkin’s disease. British Journal of Cancer, 85, 350-356. doi:10.1054/bjoc.2001.1872
[34]	Keegan, T.H.M., Glaser, S.L., Clarke, C.A., Gulley, M.L., Craig, F.E., DiGiuseppe, J.A., et al. (2005) Epstein-Barr virus as a marker of survival after Hodgkin’s lymphoma: A population-based study. Journal of Clinical Oncology, 23, 7604-7613. doi:10.1200/JCO.2005.02.6310.
[35]	Jarrett, R.F., Stark, G.L., White, J., Angus, B., Alexander, F.E., Krajewski, A.S., et al. (2005) Impact of tumor Epstein-Barr virus status on presenting features and outcome in age-defined subgroups of patients with classic Hodgkin lymphoma: a population-based study. Blood, 106, 2444- 2451. doi:10.1182/blood-2004-09-3759
[36]	Jarrett, R.F. (2002) Viruses and Hodgkin’s lymphoma. Annals of Oncology, 13, 23-29.
[37]	Armstrong, A.A., Alexander, F.E., Cartwright, R., Angus, B., Krajewski, A.S., Wright, D.H., et al. (1998) Epstein- Barr virus and Hodgkin’s disease: Further evidence for the three disease hypothesis. Leukemia, 12, 1272-1276. doi:10.1038/sj.leu.2401097
[38]	Goedert, J.J., (2000) The epidemiology of acquired immunodeficiency syndrome malignancies. Seminars in Oncology, 27, 390-401.
[39]	Frisch, M., Biggar, R.J., Engels, E.A. and Goedert, J.J. (2001) Association of cancer with AIDS-related immunosuppression in adults. The Journal of the American Medical Association, 285, 1736-1745. doi:10.1001/jama.285.13.1736
[40]	Clarke, C.A. and Glaser, S.L. (2001) Epidemiologic trends in HIV-associated lymphomas. Current Opinion in Oncology, 13, 315-413. doi:10.1097/00001622-200109000-00007
[41]	Glaser, S.L., Clarke, C.A., Gulley, M.L., Craig, F.E., DiGiuseppe, J.A., Dorfman, R.F., et al. (2003) Population based patterns of human immunodeficiency virus related Hodgkin lymphoma in the Greater San Francisco Bay Area, 1988-1998. Cancer, 98, 300-309. doi:10.1002/cncr.11459
[42]	Filipovich, A., Mathur, A., Kamat, D. and Shapiro, R. (1992) Primary immunodeficiencies: Genetic risk factors for lymphoma. Cancer Research, 52, 5465S.
[43]	Rowlings, P.A., Curtis, R.E., Passweg, J.R., Deeg, H.J., Socié, G., Travis, L.B., et al. (1999) Increased incidence of Hodgkin’s disease after allogeneic bone marrow transplantation. Journal of Clinical Oncology, 17, 3122-3127.
[44]	Haim, N., Cohen, Y. and Robinson, E. (1982) Malignant lymphoma in first degree blood relatives. Cancer, 49, 2197-2200. doi:10.1002/1097-0142(19820515)49:10<2197::AID-CNCR2820491036>3.0.CO;2-9.
[45]	Abramson, J., Pridan, H., Sacks, M., Avitzour, M., Peritz, E. (1978) A case-control study of Hodgkin’s disease in Israel. Journal of the National Cancer Institute, 61, 307-314.
[46]	Goldin, L., McMaster, M., Ter-Minassian, M., Saddlemire, S., Harmsen, B., Lalonde, G., et al. (2005) A genome screen of families at high risk for Hodgkin lymphoma: Evidence for a susceptibility gene on chromosome 4. Journal of Medical Genetics, 42, 595-601. doi:10.1136/jmg.2004.027433.
[47]	Easton, D. and Peto, J. (1990) The contribution of inherited predisposition to cancer incidence. Cancer Survivors, 9, 395-416.
[48]	Oza, A.M., Tonks, S., Lim, J., Fleetwood, M.A., Lister, T.A., Bodmer, J.G., et al. (1994) A clinical and epidemicological study of human leukocyte antigen-DPB alleles in Hodgkin’s disease. Cancer Research, 54, 5101.
[49]	Lindelöf, B. and Eklund, G. (2001) Analysis of hereditary component of cancer by use of a familial index by site. The Lancet, 358, 1696-1698. doi:10.1016/S0140-6736(01)06721-6
[50]	Matricardi, P.M. and Bonini, S. (2000) High microbial turnover rate preventing atopy: A solution to inconsistencies impinging on the Hygiene hypothesis? Clinical & Experimental Allergy, 30, 1506-1510. doi:10.1046/j.1365-2222.2000.00994.x.
[51]	Cozen, W., Hamilton, A.S., Zhao, P., Salam, M.T., Deapen, D.M., Nathwan, B.N., et al. (2009) A protective role for early oral exposures in the etiology of young adult Hodgkin lymphoma. Blood, 114, 4014-4020. doi:10.1182/blood-2009-03-209601.