Combination Therapy of Multiple Micro Trauma Technology on Hepatocellular Carcinoma

Xinfeng Li, Guorong Lu, Dexin Liu, Gaoxiong Wang, Shilin Li, Wei Zhuang

Department of Hepatobiliary Surgery, Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.
Department of Radiology, Second Affiliated Hospital of Fujian Medical University, Quanzhou, China..
Department of Ultrasound, Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.

DOI: 10.4236/jct.2013.43084                

Abstract

Objective: To compare efficacy of therapy scheme as Transhepatic Artery Chemoembolization (TACE) + Radiofrequency Ablation (RFA) + Introportal Vein Chemotherapy (PVC) + Percutaneous Ethanol Injection (PEI) therapy (quadruplet group) with TACE + RFA combinational therapy (diad group) in treating hepatocellular carcinoma (HCC). Methods: 25 cases in quadruplet group were treated by TACE for 3 weeks, then by RFA, after 2 months, by PVC + PEI; 23 cases in diad group were treated by TACE for 3 weeks and then by PEI. After completion of each treatment course in both groups, Alphafetoprotein (AFP) was tested 2 months later; abdomen colorful doppler, CT and AFP were retested 6 months later. Results: AFP was significantly decreased in 23 cases of quadruplet group and 20 cases of diad group among those with AFP positive results. 6 months later, examinations of CT, colorful Doppler and AFP in two groups showed: quadruplet group has significantly decreased (X² = 6.81, P < 0.01) blood supply of cancer tissue and significantly diminished (X² = 8.29, P < 0.01) tumor size, few cases with AFP elevation (X² = 5.06, P < 0.05); lower 1 year relapse rate and two years mortality than that in diad group (X² = 5.30, P < 0.05). Conclusion: TACE + RFA + PVC + PEI combinational therapy is a safe double intervention treatment for HCC scheme with less side effects, which is better than TACE + PEI scheme in killing remnant tumor and reducing relapse.

Keywords

Hepatocellular Carcinoma; Radiofrequency Ablation; Hepatic Artery; Chemoembolization

Conflicts of Interest

The authors declare no conflicts of interest.

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