Body temperature control in fever modeling after preliminary injection of glutamate receptors ligands into the solitary tract nucleus

Stanislav V. Koulchitsky, Svetlana G. Pashkevich, Nastassia M. Navasiolava, Marc-Antoine Custaud, Vladimir A. Kulchitsky

Institute of Physiology of NAS of Belarus, Minsk, Belarus.
The National Centre for Scientific Research, Joint Research Unit 6214 - The French National Institute of Health and Medical Research, Joint Research Unit 1083.

DOI: 10.4236/abb.2013.44073                

Abstract

Deep body temperature of 57 male Wistar rats was measured in response to systemic (i.v. or i.p.) injection of Escherichia coli lipopolysaccharide (LPS). Animals were preliminarily (4 weeks before the experiment) treated with microinjections of the toxic dose of glutamate receptors agonists or vehicle into solitary tract nucleus or caudal part of ventrolateral medulla. Microinjections of the glutamate receptors agonists provoked a local destruction of brain tissue, which was accompanied by the significant transformation (amplification or attenuation) of temperature response to the systemic injection of 3 μg/kg E. coli LPS. Animals treated with vehicle did not demonstrate significant changes in their response to LPS. Obtained data testify that impairment of central nervous structure involved in the regulation and maintenance of deep body temperature is accompanied by atypical development of E. coli LPS-induced fever.

Keywords

Escherichia coli; Endotoxin; Brainstem; Fever; Control Body Temperature; Defense Reflexes

Conflicts of Interest

The authors declare no conflicts of interest.

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