STYK1/NOK—A Potential Radiotherapeutic Target and Biomarker for Gastric Cancer and Cervical Cancer

Ling Gao, Xiaohua Chen, Zenghai Ma, Fengsheng Li

College of Life Science and Technology, Xinjiang University, Urumchi, China.
Department of Experimental Therapy of Acute Radiation Sickness, Beijing Institute of Radiation Medicine, Beijing, China.
Key Laboratory of Radiological Protection and Nuclear Emergency, National Institute for Radiological Protection, China Centers for Disease Control, Beijing, China.
The Second Artillery Journal Hospital People’s Liberation Army, Beijing, China.

DOI: 10.4236/jct.2013.42073                

Abstract

This article introduced the STYK1/NOK, including its origin, chemical composition and biological function, and the expression of STYK1/NOK in various cancer cell lines was reviewed. Furthermore, our recent study showed that STYK1/NOK protein was also over expressed in gastric cancer and cervical cancer specimens, and STYK1/NOK expression increased after tumor cells were irradiated with γ ray. These results indicated that STYK1/NOK might be involved in the occurrence and progress of gastric cancer and cervical cancer, and contribute to the radioresistance of tumor cells. Thus, STYK1/NOK might be a potential therapeutic target and diagnostic marker for gastric cancer and cervical cancer.

Keywords

Gastric Cancer; Cervical Cancer; STYK1/NOK; Therapeutic Target

Conflicts of Interest

The authors declare no conflicts of interest.

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