Medial temporal lobe volume predicts rate of learning in Rey-AVLT

Sven-Erik Fernaeus, Per Julin, Ove Almqvist, Lars-Olof Wahlund

Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden.

DOI: 10.4236/aad.2013.21002                

Abstract

The medial temporal lobe (MTL) has been assigned a central role in human episodic memory and learning. Evidence for this comes from PET and fMRI studies as well as lesion studies. This study aimed at comparing the effect of atrophy at repeated trials of a supraspan test of memory. Included in the study were patients with Alzheimer’s Disease, Mild Cognitive Impairment, and Subjective Memory Disorders as well as Controls (n = 116). The supraspan test used was the Rey Auditory Verbal Learning test (RAVLT). Comparisons between extreme groups with high (Stanine 6 - 9) and low (Stanine 1 - 4) intracranial proportions (IP) of MTL were made at the five trials of RAVLT. There was a significantly higher rate of learning among subjects with high MTL IP compared to those with low MTL IP in both hemispheres. There was no difference in the rate of list learning performance due to education or age and interestingly: the list learning rates among subjects with high/low Lateral Temporal Lobe IPs were almost similar. The hemispheric differences regarding learning rate were small and insignificant. Results are discussed in terms of hippocampal involvement in associative processes necessary in supraspan list learning.

Keywords

Hippocampus; Learning; Medial Temporal Lobe; Episodic Memory; MRI; Atrophy

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1]	Squire, L. and Zola-Morgan, S. (1991) The medial temporal lobe memory system. Science, 253, 1380-1386. doi:10.1126/science.1896849
[2]	Squire, L. (1992) Memory and the hippocampus: A synthesis from findings with rats, monkeys and humans. Psychological Review, 99, 195-231. doi:10.1037/0033-295X.99.2.195
[3]	Cohen, N.J. and Eichenbaum, H. (1993) Memory, amnesia, and the hippocampal system. MIT Press, Cambridge.
[4]	Eichenbaum, H., Otto, T. and Cohen, N.J. (1994) Two functional components of the hippocampal memory system. Behavioural & Brain Science, 17, 449-518.
[5]	Tulving, E., Kapur, S., Craik, F., Moscovitch, M. and Houle, S. (1994) Hemispheric encoding/retrieval asymmetry in episodic memory: Positron emission findings. Proceedings of the National Academy of Sciences of the United States of America, 91, 2016-2020. doi:10.1073/pnas.91.6.2016
[6]	Tulving, E., Markowitsch, H.J., Craik, F.I.M., Habib, R. and Houle, S. (1996) Novelty and familiarity activations in PET studies of memory encoding and retrieval. Cerebral Cortex, 6, 71-79. doi:10.1093/cercor/6.1.71
[7]	Knight, R.T. (1996) Contribution of human hippocampal region to novelty detection. Nature, 383, 256-259. doi:10.1038/383256a0
[8]	Scoville, W. and Milner, B. (2000) Loss of recent memory after bilateral hippocampal lesions. Journal of Neuropsychiatry Clinical Neuroscience, 12, 103-113.
[9]	Penfield, W. and Milner, B. (1958) Memory deficit produced by bilateral lesions in the hippocampal zone. AMA Archives of Neurology and Psychiatry, 79, 475-497. doi:10.1001/archneurpsyc.1958.02340050003001
[10]	Zola-Morgan, S., Squire, L.R. and Amaral, D.G. (1986) Human amnesia and the medial temporal region: Enduring memory impairment following a bilateral lesion limited to field CA1 of the hippocampus. Journal of Neuroscience, 6, 2950-2967.
[11]	Victor, M. and Agamanolis, D. (1990) Amnesia due to lesions confined to the hippocampus: A clinical-pathologic study. Journal of Cognition Neuroscience, 2, 246-257. doi:10.1162/jocn.1990.2.3.246
[12]	Rempel-Clower, N., Zola, S., Squire, L. and Amaral, D. (1996) Three cases of enduring memory impairment after bilateral damage limited to the hippocampal formation. The Journal of Neuroscience, 16, 5233-5255.
[13]	Jones-Gotman, M., Zatorre, R.J., Olivier, A., Andermann, F., Cendes, F., Staunton, H., McMackin, D., Siegel, A. and Wieser, H.-G. (1997). Learning and retention of words and designs following excision from medial or lateral temporal-lobe structures. Neuropsychologia, 35, 963-973. doi:10.1016/S0028-3932(97)00024-9
[14]	Kapur, S., Craik, F.I.M., Tulving, E., Wilson, A.A., Houle, S. and Brown, G.M. (1994) Neuroanatomical correlates of encoding in episodic memory: levels of processing effect. Proceedings of the National Academy of Sciences of the United States of America, 19, 2008-2011. doi:10.1073/pnas.91.6.2008
[15]	Kapur, S., Tulving, E., Cabeza, R., McIntosh, A.R., Houle, S. and Craik, F.I.M. (1996) Neural correlates of intentional learning of verbal materials: A PET study in humans. Cognitive Brain Research, 4, 243-249. doi:10.1016/S0926-6410(96)00058-4
[16]	Nyberg, L., McIntosh, A.R., Houle, S., Nilsson, L.G. and Tulving, E. (1996) Activation of medial temporal structures during episodic memory retrieval. Nature, 25, 669-670.
[17]	Shallice, T., Fletcher, P., Frith, C.D., Grasby, P., Frackowiak, R.S.J. and Dolan, R.J. (1994) Brain regions associated with aquisition and retrieval of verbal episodic memory. Nature, 368, 633-635. doi:10.1038/368633a0
[18]	Tulving, E., Kapur, S., Craik, F.I.M., Moscovitch, M. and Houle, S. (1994) Hemispheric encoding/retrieval asymmetry in episodic memory: Positron emission tomography findings. Proceedings of the National Academy of Sciences of the United States of America, 91, 2016-2020. doi:10.1073/pnas.91.6.2016
[19]	Gabrieli, J.D.E., Brewer, J.B., Desmond, J.E. and Glover, G.H. (1997) Separate neural bases of two fundamental memory processes in the human medial temporal lobe. Science, 276, 264-266. doi:10.1126/science.276.5310.264
[20]	Grady, C.L., McIntosh, A.R., Horwitz, B., Maisog, J.M., Ungerleider, L.G., Mentis, M.J., Pietrini, P., Schapiro, M.B. and Haxby, J.V. (1995) Age-related reductions in human recognition memory due to impaired encoding. Science, 269, 218-221. doi:10.1126/science.7618082
[21]	Stern, C.E., Corkin, S., Gonzales, R.G., Guimares, A.R., Baker, J.R., Jennings, P.J., Carr, C.A., Sugiura, R.M., Vedantham, V. and Rosen, B.R. (1996) The hippocampal formation participates in novel picture encoding: Evidence from functional magnetic resonance imaging. Proceedings of the National Academy of Sciences of the United States of America, 93, 8660-8665. doi:10.1073/pnas.93.16.8660
[22]	Tulving, E., Kapur, S., Markowitsch, H.J., Craik, F.I.M., Habib, R. and Houle, S. (1994) Neuroanatomical correlates of retrieval in episodic memory: Auditory sentence recognition. Proceedings of the National Academy of Sciences of the United States of America, 91, 2012-2015. doi:10.1073/pnas.91.6.2012
[23]	Fernandez, G., Weyerts, H., Schrader-Bolsche, M., Tendolkar, I., Smid., H.O.M., Tempelmann, C., Hinrichs, H., Schein, H., Elger, C.E., Mangun, G.R. and Heinze, H.-J. (1998) Successful verbal encoding into episodic memory engages the posterior hippocampus: A parametrically analyzed functional magnetic resonance imaging study. The Journal of Neuroscience, 18, 1841-1847.
[24]	Henke, K., Buck, A., Weber, B. and Wieser, H.G. (1998) Human hippocampus establishes associations in memory. Hippocampus, 7, 249-256. doi:10.1002/(SICI)1098-1063(1997)7:3<249::AID-HIPO1>3.0.CO;2-G
[25]	Rombouts, S.A.R.B., Machielsen, W.C.M., Witter, M.P., Barkhof, F., Lindeboom, J. and Scheltens, P. (1997) Visual association encoding activates the medial temporal lobe: A functional magnetic resonance imaging study. Hippocampus, 7, 594-601. doi:10.1002/(SICI)1098-1063(1997)7:6<594::AID-HIPO2>3.0.CO;2-F
[26]	Soininen, H.S., Partanen, K., Pikanen, A., Vainio, P., Hanninen, T., Hallikainen, M., Koivisto, K. and Riekkinen, P.J. (1994) Volumetric MRI analysis of the amygdala and the hippocampus in subjects with age-associated memory impairment: Correlation to visual and verbal memory. Neurology, 44, 1660-1668. doi:10.1212/WNL.44.9.1660
[27]	Squire, L.R. (1992) Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans. Psychological Review, 99, 195-231. doi:10.1037/0033-295X.99.2.195
[28]	Rey, A. (1964) L’exconen clinique en psychologie. Presses Universitaires de France, Paris.
[29]	Julin, P., Melin, T., Andersen, C., Isberg, B., Svensson, L. and Wahlund, L.-O. (1997) Reliability of interactive three-dimensional brain volumetry using MP-RAGE magnetic resonance imaging. Psychiatry Research, 76, 41-49.
[30]	Almkvist, O. (1996) Neuropsychological features of early Alzheimer’s disease: Preclinical and clinical stages. Acta Neurologica Scandinavica Supplement, 165, 63-71. doi:10.1111/j.1600-0404.1996.tb05874.x
[31]	Jones-Gotman, M. and Milner, B. (1998) Right temporal-lobe contribution to image-mediated verbal learning. Neuropsychologia, 16, 61-71. doi:10.1016/0028-3932(78)90043-X