Error Corrected Sub-Monolayer Ellipsometry for Measurement of Biomolecular Interactions

Udo Riss

DRE-Dr. Riss Ellipsometerbau GmbH, Ratzeburg, Germany.

DOI: 10.4236/ojbiphy.2013.31A010                

Abstract

Already in 1946 Alexandre Rothen from the Rockefeller Institute for Medical Research, New York published the use of ellipsometry for the measurement of antigen-antibody interactions. And he found some effects that could not be explained by the assumption that the interaction of the molecules is only of chemical nature. 55 years later we started research on antibody-antigen interaction and found similar results. To make sure that these measurements are not produced by measurement artifacts, each component of our measurement technique is error analyzed and error corrected if necessary. With such type of error corrected instrumentation we found, that there must be an interaction between antigens and antibodies that is based on longitudinal electromagnetic waves, which are able to work through thin 7 nm membranes. A similar interaction is found for the virus-antigen interaction. Our measurement results are in contrast to the assumption that the antigen-antibody and antigen-virus interaction is only of chemical nature.

Keywords

Ellipsometry; Ellipsometer; Antibody; Antigen; Virus; Membrane; Kinetics; Electrodynamics

Conflicts of Interest

The authors declare no conflicts of interest.

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