Use of Solid-Supported Reagents towards Synthesis of 2-Arylbenzoxazole, 3, 5-Diarylisoxazole and 1, 3, 5-Triarylpyrazole

Sneha Naik, Vidya Desai

Department of Chemistry, Dnyanprassarak Mandal’s College of Arts, Science and Commerce, Mapusa, India.

DOI: 10.4236/gsc.2013.31001                

Abstract

Herein we report a convenient and efficient synthesis of 2-Arylbenzoxazole from the Schiff’s bases of 2-Aminophenol, 3, 5-Diarylisoxazole from α, β-unsaturated ketoxime and 1,3,5-Triarylpyrazole from 2-pyrazoline and N-Arylhydrazone by using milder, less toxic and less expensive-NBS-SiO₂, KMnO₄-Al₂O₃, PCC-SiO₂ and ACC-Al₂O₃ as solid-supported oxidizing agents at room temperature. Within the framework of Green Chemistry, the use of solid supported reagents has many advantages such as 1) they are easy to remove from reactions by filtration 2) excess reagents can be used to drive the reaction without introducing any difficulties in purification 3) such solid-supported reagents react differently, mostly more selectively, than their unbound counterparts and 4) toxic, noxious and explosive chemicals are handled more safely when contained on solid support.

Keywords

Schiff’s Bases; 3, 5-Diarylisoxazoles; 2-ArylBenzoxazoles; 1, 3, 5-Triaryl Pyrazoles; Solid-Supported Reagents

Conflicts of Interest

The authors declare no conflicts of interest.

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