Health> Vol.5 No.1, January 2013
Downloads: 621     Views: 1,642

Modulation of peroxisomes abundance by argan oil and lipopolysaccharides in acyl-CoA oxidase 1-deficient fibroblasts

ABSTRACT

Pseudo-neonatal adrenoleukodystrophy (P-NALD) is a neurodegenerative disorder caused by acyl-CoA oxidase 1 (ACOX1) deficiency with subsequent impairment of peroxisomal fatty acid β-oxidation, accumulation of very long chain fatty acids (VLCFAs) and strong reduction in peroxisome abundance. Increase in peroxisome number has been previously suggested to improve peroxisomal disorders, and in this perspective, the present work was aimed at exploring whether modulation of peroxisomes abundance could be achieved in P-NALD fibroblasts. Here we showed that treatment with the natural Argan oil induced peroxisome proliferation in P-NALD fibroblasts. This induction was independent on activations of both nuclear receptor PPARα and its coactivator PGC-1α. Lipopolysaccharides (LPS) treatment, which caused inflammation, induced also a peroxisome proliferation that, in contrast, was dependent on activations of PPARα and PGC-1α. By its ability to induce peroxisome proliferation, Argan oil is suggested to be of potential therapeutic use in patients with P-NALD.

KEYWORDS


Cite this paper

El Kebbaj, R. , Kamouni, S. , El Hajj, H. , Andreoletti, P. , Gresti, J. , Latruffe, N. , El Kebbaj, M. , Vamecq, J. , Lizard, G. , Nasser, B. and Cherkaoui-Malki, M. (2013) Modulation of peroxisomes abundance by argan oil and lipopolysaccharides in acyl-CoA oxidase 1-deficient fibroblasts. Health, 5, 62-69. doi: 10.4236/health.2013.51009.

References

[1] Poll-The, B.T., et al. (1988) A new peroxisomal disorder with enlarged peroxisomes and a specific deficiency of acyl-CoA oxidase (pseudo-neonatal adrenoleukodystrophy). American Journal of Human Genetics, 42, 422-434.
[2] Wanders, R.J. and Waterham, H.R. (2006) Peroxisomal disorders: the single peroxisomal enzyme deficiencies. Biochimica et Biophysica Acta, 1763, 1707-1720. doi:10.1016/j.bbamcr.2006.08.010
[3] El Hajj, H.I. et al. (2012) The inflammatory response in acyl-CoA oxidase 1 deficiency (pseudoneonatal adreno-leukodystrophy). Endocrinology, 153, 2568-2575. doi:10.1210/en.2012-1137
[4] Cherkaoui-Malki, M., et al. (2012) Hepatic steatosis and peroxisomal fatty acid beta-oxidation. Current Drug Metabolism, 13, 1412-1421. doi:10.2174/138920012803762765
[5] Reddy, J.K. (2004) Peroxisome proliferators and peroxisome proliferator-activated receptor alpha: Biotic and xenobiotic sensing. American Journal of Pathology, 164, 2305-2321. doi:10.1073/pnas.1009176107
[6] Delille, H.K., Alves, R. and Schrader, M. (2009) Biogenesis of peroxisomes and mitochondria: Linked by division. Histochemistry and Cell Bi-ology, 131, 441-446.
[7] Girzalsky, W., Saffian, D. and Erd-mann, R. (2010) Per- oxisomal protein translocation. Biochimica et Biophysica Acta, 1803, 724-731.
[8] Bagattin, A., Hugendubler, L. and Mueller, E. (2010) Transcriptional coacti-vator PGC-1α promotes peroxisomal remodeling and bioge-nesis. Proceedings of the Na- tional Academy of Sciences, 107, 20376-20381.
[9] Cherkaoui-Malki, M., et al. (2001) Identi-fication of novel peroxisome proliferator-activated receptor alpha (PPARα) target genes in mouse liver using cDNA microarray analysis. Gene Expression, 9, 291-304.
[10] Vluggens, A. and Reddy, J.K. (2012) Nuclear receptors and transcription factors in the development of fatty liver disease. Current Drug Metabolism, 13, 1422-1435. doi:10.2174/138920012803762710
[11] Forman, B.M., Chen, J. and Evans, R.M. (1997) Hypol- ipidemic drugs, polyunsatu-rated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta. Proceedings of the National Academy of Sciences, 94, 4312-4317. doi:10.1073/pnas.94.9.4312
[12] Gottlicher, M., et al. (1992) Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor. Proceedings of the National Academy of Sciences, 89, 4653-4657. doi:10.1073/pnas.89.10.4653
[13] Issemann, I. and Green, S. (1990) Activation of a member of the steroid hormone receptor superfamily by perox- isome proliferators. Nature, 347, 645-650. doi:10.1038/347645a0
[14] Fan, C.Y., et al. (1998) Steatohe-patitis, spontaneous peroxisome proliferation and liver tumors in mice lacking peroxisomal fatty acyl-CoA oxidase. Implications for per- oxisome proliferator-activated receptor alpha natural lig- and metabolism. Journal of Biological Chemistry, 273, 15639-15645. doi:10.1074/jbc.273.25.15639
[15] Huang, J., et al. (2011) Progressive endoplasmic reticulum stress contributes to hepatocarcinogenesis in fatty acyl-CoA oxidase 1-deficient mice. The American Jour- nal of Pathology, 179, 703-713. doi:10.1016/j.ajpath.2011.04.030
[16] Vluggens, A., et al. (2010) Reversal of mouse Acyl-CoA oxidase 1 (ACOX1) null phenotype by human ACOX1b isoform [corrected]. Laboratory Investigation: A Journal of Technical Methods and Pathology, 90, 696-708.
[17] Ferdinandusse, S., et al. (2007) Clinical, biochemical, and mutational spectrum of peroxisomal acyl-coenzyme A oxidase deficiency. Human Mutation, 28, 904-912. doi:10.1002/humu.20535
[18] Wei, H., et al. (2000) Pharma-cological induction of peroxisomes in peroxisome biogenesis disorders. Annals of neurology, 47, 286-296. doi:10.1002/1531-8249(200003)47:3<286::AID-ANA3>3.0.CO;2-B
[19] Paintlia, M.K., et al. (2008) Lipopolysaccha-ride-induced peroxisomal dysfunction exacerbates cerebral white matter injury: Attenuation by N-acetyl cysteine. Experimental Neurology, 210, 560-576. doi:10.1016/j.expneurol.2007.12.011
[20] Baarine, M., et al. (2009) Peroxisomal and mitochondrial status of two murine oligodendrocytic cell lines (158N, 158JP): Potential models for the study of peroxisomal disorders associated with dysmyelination processes. Journal of Neurochemistry, 111, 119-131. doi:10.1111/j.1471-4159.2009.06311.x
[21] Schrader, M., Krieglstein, K. and Fahimi, H. D. (1998) Tubular peroxisomes in HepG2 cells: Selective induction by growth factors and ara-chidonic acid. European Journal of Cell Biology, 75, 87-96. doi:10.1016/S0171-9335(98)80051-4
[22] Savary, S., et al. (2012) Fatty acids-induced lipotoxicity and inflammation. Current Drug Metabolism, 13, 1358- 1370. doi:10.2174/138920012803762729
[23] Gondcaille, C., et al. (2005) Phenylbutyrate up-regulates the adrenoleukodystro-phy-related gene as a nonclassical peroxisome proliferator. Journal of Cell Biology, 169, 93-104. doi:10.1083/jcb.200501036
[24] Zhang, X., et al. (2006) Peroxisome proliferator-activated receptor alpha-independent pe-roxisome proliferation. Biochemical and Biophysical Research Communications, 346, 1307-1311. doi:10.1016/j.bbrc.2006.06.042
[25] Gloerich, J., et al. (2005) A phytol-enriched diet induces changes in fatty acid metabolism in mice both via PPARα-dependent and -independent pathways. Journal of Lipid Research, 46, 716-726. doi:10.1194/jlr.M400337-JLR200
[26] DeLuca, J.G., et al. (2000) Evidence for peroxisome proliferator-activated receptor (PPAR)α-independent peroxisome proliferation: Effects of PPARγ/delta-specific agonists in PPARαlphanull mice. Moecular Pharmacology, 58, 470-476.
[27] Jia, Y., et al. 2003) Overexpression of peroxisome proliferator-activated recep-tor-alpha (PPARα)-regulated genes in liver in the absence of peroxisome proliferation in mice deficient in both L- and D-forms of enoyl-CoA hydra- tase/dehydrogenase enzymes of peroxisomal beta-oxidation system. Journal of Biological Chemistry, 278, 47232- 47239. doi:10.1074/jbc.M306363200
[28] Contreras, M.A., et al. (2000) Endotoxin induces structure-function alterations of rat liver peroxisomes: Kupffer cells released factors as possible modulators. Hepatology, 31, 446-455. doi:10.1002/hep.510310226
[29] Dhaunsi, G.S., Hanevold, C.D. and Singh, I. (1994) Im pairment of peroxisomal beta-oxidation system by endotoxin treatment. Molecular and Cellular Biochemistry, 135, 187-193. doi:10.1007/BF00926522
[30] Khan, M., et al. (1998) Cyto-kine-induced accumulation of very long-chain fatty acids in rat C6 glial cells: Implication for X-adrenoleukodystrophy. Journal of neuro- chemistry, 71, 78-87. doi:10.1046/j.1471-4159.1998.71010078.x
[31] Paintlia, M.K., et al. (2008) Modulation of peroxisome proliferator-activated receptoralpha activity by N-acetyl cysteine attenuates inhibition of oligodendrocyte development in lipopolysaccharide stimulated mixed glial cultures. Journal of Neurochemistry, 105, 956-970. doi:10.1111/j.1471-4159.2007.05199.x
[32] Schilling, J., et al. (2011) Toll-like receptor-mediated inflammatory signaling reprograms cardiac energy metabolism by repressing peroxi-some proliferator-activated receptor gamma coactivator-1 signaling. Circulation: Heart Failure, 4, 474-482. doi:10.1161/CIRCHEARTFAILURE.110.959833

comments powered by Disqus

Copyright © 2014 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.