Concomitant Occurrence of Segmental Neurofibromatosis and Lung Adenocarcinoma

Ryoko Morita, Naoki Oiso, Akira Kawada

Department of Dermatology, Faculty of Medicine, Kinki University, Osaka, Japan.
Department of Dermatology, Faculty of Medicine, Kinki University, Osaka, Japan..

DOI: 10.4236/jcdsa.2012.24050                

Abstract

Neurofibromatosis type 1 (NF1) caused by a loss-of functional mutation in NF1 encoding neurofibromin is an autosomal dominant disorder characterized by café-au-lait spots, neurofibromas, intertriginous freckles, and Lisch nodules. Segmental neurofibromatosis (SN) represents a postzygotic mutation and loss of heterozygosity in neurofibromin. SN occurring in the elder persons may be associated with internal malignant tumors. Here, we reported a case of 58-year-old woman with concomitant occurrence of SN and lung adenocarcinoma. The onset of SN in aged persons would be a sign of concomitant occurrence of internal malignant tumors.

Keywords

Segmental Neurofibromatosis; Lung Adenocarcinoma; Internal Malignant Tumors

Conflicts of Interest

The authors declare no conflicts of interest.

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