Rationale and Role of High Loading Dose Clopidogrel in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention

Sam T. Mathew, Gayathri Devi S, Prasanth V. V, Vinod B

Accenture Pharmaceutical Services, Bangalore, India.
Department of Pharmaceutical Chemistry, Pushpagiri College of Pharmacy, Thiruvalla, Kerala, India.
Department of Pharmaceutics Sikkim Manipal University, Bangalore, India.
Department of Pharmaceutics, Gautham College of Pharmacy, Bangalore, India.

DOI: 10.4236/pp.2012.34066                

Abstract

Antiplatelet therapy, which reduces platelet activation and aggregation, is the corner stone of treatment for patients undergoing percutaneous coronary intervention (PCI). Clopidogrel is an established oral antiplatelet medication of thienopyridine class, which inhibits blood clots in coronary artery disease, peripheral vascular disease, and cerebrovascular disease. Many studies have revealed that high loading dose clopidogrel in patients undergoing PCI. This review article investigates the rationale and role of high loading dose clopidogrel in patients undergoing PCI.

Keywords

Clopidogrel; Antiplatelet Therapy; Percutaneous Coronary Intervention

Conflicts of Interest

The authors declare no conflicts of interest.

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