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Facile One-Pot Synthesis of Novel Hexahydro-2-quinolinecarboxylic Acids under Solvent-Free Reaction Conditions

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DOI: 10.4236/ijoc.2012.23037    3,345 Downloads   6,171 Views   Citations


A simple and fastthree-component synthesis of new and biologically active hexahydro-2-quinolinecarboxylic acid scaf-fold 4 was carried out using cyclocondensation reaction of arylmethylidenepyruvic acids 1, 1,3-cyclohexandiones 2 and ammonium acetate 3 under solvent-free conditions and at room temperature. This protocol has the advantages of facility, easy work-up, high yields, short reaction time and environmentally friendly character.

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S. Balalaie, S. Abdolmohammadi and B. Soleimanifard, "Facile One-Pot Synthesis of Novel Hexahydro-2-quinolinecarboxylic Acids under Solvent-Free Reaction Conditions," International Journal of Organic Chemistry, Vol. 2 No. 3, 2012, pp. 276-281. doi: 10.4236/ijoc.2012.23037.


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