Angiolymphoid Hyperplasia with Eosinophilia—A Case Report

Pankaj Kumar Doloi, Swagata Khanna

Department of ENT, Gauhati Medical College & Hospital, Guwahati, Assam, India.
ENT, Head & Neck Clinic, Swagat ESRI, Guwahati, Assam, India.

DOI: 10.4236/ijohns.2012.12009                

Abstract

Angiolymphoid hyperplasia with eosinophilia is a rare, benign vascular tumor affecting principally the head and neck region of young adult females. Microscopic analysis reveals hyperplastic blood vessels lined by a hypertrophic endothelium. An inflammatory infiltrate rich in eosinophils is also present. Etiology of the lesion is unknown. Various treatment modalities have been described. We present a case successfully treated by excision and local steroid infiltration.

Keywords

Angiolymphoid Hyperplasia with Eosinophilia (ALHE); Epithelioid Haemangioma; Histiocytoid Haemangioma; Kimura’s Disease

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1]	M. V. Botet and J. L. Sanchez, “Angiolymphoid Hyperplasia with Eosinophilia: Report of a Case and a Review of the Literature,” Journal of Dermatologic Surgery and Oncology, Vol. 4, No. 12, 1978, pp. 931-936.
[2]	W. Kempf, A. C. Haeffner, K. Zepter, C. A. Sander, M. J. Flaig, B. Mueller, R. G. Panizzon, T. Hardmeier, V. Adams and G. Burg, “Angiolymphoid Hyperplasia with Eosinophilia: Evidence for a T-Cell Lymphoproliferative Origin,” Human Pathology, Vol. 33, No. 10, 2002, pp. 10231029. doi:10.1053/hupa.2002.128247
[3]	A. V. Pe?a, E. de D. Rodríguez, J. M. G. Ortega, A. H. Castrillo and G. L. Rasines, “Considerations about Angiolymphoid Hyperplasia with Eosinophilia (ALHE) with Regard to a Case Localized in the Penis,” Actas Urológicas Espa?olas, Vol. 29, No. 1, 2005, pp. 113-117. doi:10.4321/S0210-48062005000100020
[4]	G. C. Wells and I. W. Whimster, “Subcutaneous Angiolymphoid Hyperplasia with Eosinophilia,” British Journal of Dermatology, Vol. 81, No. 1, 1969, pp. 1-15. doi:10.1111/j.1365-2133.1969.tb15914.x
[5]	C. A. Moran and S. Suster, “Angiolymphoid Hyperplasia with Eosinophilia (Epithelioid Hemangioma) of the Lung: A Clinicopathologic and Immunohistochemical Study of Two Cases,” American Journal of Clinical Pathology, Vol. 123, No. 5, 2005, pp. 762-765. doi:10.1309/UN1AQ2WJU9HDD72F
[6]	T. G. Olsen and E. B. Helwig, “Angiolymphoid Hyperplasia with Eosinophilia: A Clinicopathologic Study of 116 Patients,” Journal of American Academy of Dermatology, Vol. 12, No. 5, 1985, pp. 781-796. doi:10.1016/S0190-9622(85)70098-9
[7]	P. L. Ramchandani, T. Sabesan and K. Hussein, “Angiolymphoid Hyperplasia with Eosinophilia Masquerading as Kimura Disease,” British Journal of Oral Maxillofacial Surgery, Vol. 43, No. 3, 2005, pp. 249-252. doi:10.1016/j.bjoms.2004.11.023
[8]	W.-S. Chong, A. Thomas and C.-L. Goh, “Kimura’s Disease and Angiolymphoid Hyperplasia with Eosinophilia: Two Disease Entities in the Same Patient. Case Report and Review of the Literature,” International Journal of Dermatology, Vol. 45, No. 2, 2006, pp. 139-145. doi:10.1111/j.1365-4632.2004.02361.x
[9]	A. Acocella, C. Catelani and P. Nardi, “Angiolymphoid Hyperplasia with Eosinophilia: A Case Report of Orbital Involvement,” Journal of Oral and Maxillofacial Surgery, Vol. 63, No. 1, 2005, pp. 140-144. doi:10.1016/j.joms.2004.04.029
[10]	M. Azizzadeh, M. R. Namazi, L. Dastghaib and F. SariAslani, “Angiolymphoid Hyperplasia with Eosinophilia and Nephrotic Syndrome,” International Journal of Dermatology, Vol. 44, No. 3, 2005, pp. 242-244. doi:10.1111/j.1365-4632.2004.02030.x
[11]	R. K. Hejmadi, D. G. van Pittius, M. Stephens, R. Chasty and M. Braithwaite, “Angiolymphoid Hyperplasia with Eosinophilia (Epithelioid Haemangioma) Occurring within Multiple Deep Lymph Nodes and Presenting with Weight Loss and Raised CA-125 Levels,” Virchows Archiv, Vol. 448, No. 3, 2005, pp. 366-368.
[12]	A. Satpathy, C. Moss, F. Raafat and R. Slator, “Spontaneous Regression of a Rare Tumour in a Child: Angiolymphoid Hyperplasia with Eosinophilia of the Hand: Case Report and Review of the Literature,” British Journal of Plastic Surgery, Vol. 58, No. 6, 2005, pp. 865-868. doi:10.1016/j.bjps.2004.11.014
[13]	H. Suzuki, A. Hatamochi, M. Horie, T. Suzuki and S. Yamazaki, “A Case of Angiolymphoid Hyperplasia with Eosinophilia (ALHE) of the Upper Lip,” Journal of Dermatology, Vol. 32, No. 12, 2005, pp. 991-995.
[14]	N. Zarrin-Khameh, J. E. Spoden and R. M. Tran, “Angiolymphoid Hyperplasia with Eosinophilia Associated with Pregnancy: A Case Report and Review of the Literature,” Archives of Pathology & Laboratory Medicine, Vol. 129, No. 9, 2005, pp. 1168-1171.
[15]	G. Y. Zhang, J. Jiang, T. Lin and Q. Q. Wang, “Disseminated Angiolymphoid Hyperplasia with Eosinophilia: A Case Report,” Cutis, Vol. 72, No. 4, 2003, pp. 323-326.
[16]	T. Demitsu, H. Nagato and T. Inoue, “Angiolymphoid Hyperplasia with Eosinophilia: Its Character and Therapy,” Skin Surgery, Vol. 9, No. 1, 2000, pp. 8-16.
[17]	M. Braun-Falco, S. Fischer, S.-G. Pl?tz and J. Ring, “Angiolymphoid Hyperplasia with Eosinophilia Treated with Anti-Interleukin-5 Antibody (Mepolizumab),” British Journal of Dermatology, Vol. 151, No. 5, 2004, pp. 11031104. doi:10.1111/j.1365-2133.2004.06239.x